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18 Possible Causes for Bicytopenia, Complete Blood Count Abnormal, Mean Corpuscular Volume Increased

  • Gaucher Disease

    All forms of Gaucher disease affect males and females in equal numbers. Gaucher disease type 1 is the most common type, accounting for more than 90 percent of cases. Individuals with Gaucher disease type 1 usually exhibit symptoms during adolescence, but the age of onset ranges from childhood to adulthood. The[…][web.archive.org]

  • Vitamin B12 Deficiency

    When you have an abnormal complete blood count (CBC) with a blood smear showing large red blood cells (macrocytosis) or abnormal (hypersegmented) neutrophils ; when you have[labtestsonline.org] Laboratory data revealed bicytopenia with macrocytic anemia and methylmalonic acid in the urine, consistent with vitamin B12 deficient anemia.[ncbi.nlm.nih.gov] Hematological presentation of cobalamin deficiency ranges from the incidental increase of mean corpuscular volume and neutrophil hypersegmentation to symptoms due to severe[ncbi.nlm.nih.gov]

  • Leukoerythroblastic Anemia

    Pancytopenia was seen in 9.55% (17) cases and bicytopenia in 50.5% (90) patients.[jahjournal.org] mean corpuscular volume (macrocytic anemia: MCV 100 fL) Ethanol abuse Folate deficiency Vitamin B12 deficiency Myelodysplastic syndromes Acute myeloid leukemias (eg, erythroleukemia[timeofcare.com] Pancytopenia was seen in 9.55% (17) cases and bicytopenia in 50.5% (90) patients. Only eight cases had bone marrow correlation.[jahjournal.org]

  • Myelodysplasia

    WHEN TO SUSPECT MDS In many patients, MDS are asymptomatic and appear as an abnormality on a routine complete blood cell count (CBC) or as part of a workup for anemia.[mdedge.com] 2017) Age – median is 65-70 Sex – M F Classification Classification of MDS, Subtypes Subtype Blood Bone Marrow MDS cytopenias with single lineage dysplasia Unicytopenia or bicytopenia[arupconsult.com] You will also have: Blood tests — to check how many cells of each type are in your blood (complete blood count), how the cells look (peripheral blood smear) and whether they[seattlecca.org]

  • Acute Leukemia

    A 1-year-old boy presented with abnormal complete blood count findings, and was found to have blasts and mild dysgranulopoiesis.[ncbi.nlm.nih.gov] A 43-year-old female presented with leukocytosis and bicytopenia.[ncbi.nlm.nih.gov] Initial CBC showed bicytopenia, elevated blood urea, creatinine, and serum uric acid, while abdominal ultrasonography revealed bilateral renal enlargement.[ncbi.nlm.nih.gov]

  • Autoimmune Hemolytic Anemia

    Often, anemia caused by chronic diseases goes undetected until a routine test such as a complete blood count (CBC) reveals abnormal results.[labtestsonline.org] Autoimmune bicytopenia in pulmonary tuberculosis. Report of a pediatric case. Respir Med CME 2008;1:281-3. 9. Safe IP, O'brien C, Ferreira FR, Souza ML, Ramasawmy R.[jahjournal.org] Reticulocyte counts are usually elevated, and an increased MCV (mean corpuscular volume) (greater than 100 fl) can be seen, due to the larger size of reticulocytes in comparison[cancertherapyadvisor.com]

  • Acute Myelocytic Leukemia

    It has not been treated except to relieve signs and symptoms such as fever, bleeding, or pain, and the following are true: The complete blood count is abnormal.[cancer.gov] In contrast to patients with RA and only dyserythropoiesis, patients with multilineage dysplasia have bicytopenia or pancytopenia, a higher incidence of cytogenetic abnormalities[bloodjournal.hematologylibrary.org] The first clue to a diagnosis of AML is typically an abnormal result on a complete blood count.[en.wikipedia.org]

  • Primary Myelofibrosis

    Primary myelofibrosis is diagnosed using the following procedures: Blood testing: Complete blood count (CBC) looking for abnormal amounts of red and white blood cells and[patientworthy.com] Patients with primary myelofibrosis may have pancytopenia or bicytopenia and in that respect mimic patients with oligoblastic leukemia (myelodysplasia [MDS]; see Chap. 88)[patient-help.com] Tests A complete blood count (CBC) often shows abnormal blood cell counts.[mpnresearchfoundation.org]

  • Paroxysmal Nocturnal Hemoglobinuria

    Progression from bicytopenia to pancytopenia or a new episode of bicytopenia or pancytopenia after recovery was not considered as a first progression to bicytopenia or pancytopenia[bloodjournal.hematologylibrary.org] The indications included pancytopenia (all three cell lines), bicytopenia (two cell lines), and unicytopenia (one cell line).[bcmj.org] The cumulative incidence of bicytopenia or pancytopenia ( Figure 2 B) was similar in patients with classic and intermediate disease ( P .63).[bloodjournal.hematologylibrary.org]

  • Acute Erythroblastic Leukemia

    Diagnosis & Treatment Erythroleukemia is usually diagnosed by one of the following tests: Blood tests : A CBC (complete blood count) can indicate the presence of certain substances[knowcancer.com] The initial diagnoses were chronic myeloid leukemia in two, myelodysplastic syndrome in nine including four cases of Down syndrome, pancytopenia or bicytopenia in three, and[jstage.jst.go.jp] Features associated with pernicious anemia are hemolysis with increased mean corpuscular volume (MCV), hypersegmented neutrophils, leukopenia and thrombocytopenia increased[labmedicineblog.com]