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41 Possible Causes for Bicytopenia, Epistaxis, Hepatosplenomegaly

  • Gaucher Disease

    We report here the case of a young woman with hepatosplenomegaly, leukopenia, and thrombocytopenia.[ncbi.nlm.nih.gov] Epistaxis and ecchymoses resulting from thrombocytopenia are common.[merckmanuals.com] [drugbank.ca] Face, Head & Neck Epistaxis Epistaxis and ecchymoses resulting from thrombocytopenia are common.[symptoma.com]

  • Acute Myelocytic Leukemia

    In all three patients, radionuclide imaging with technetium-99m sulfur colloid showed hepatosplenomegaly, decreased liver uptake, and increased splenic activity.[ncbi.nlm.nih.gov] In contrast to patients with RA and only dyserythropoiesis, patients with multilineage dysplasia have bicytopenia or pancytopenia, a higher incidence of cytogenetic abnormalities[bloodjournal.hematologylibrary.org] […] constipation, diarrhea, oral pain, vomiting, asthenia, malaise, edema peripheral, hemoglobin decreased, decreased appetite, oropharyngeal pain, and alopecia with AML are epistaxis[neupogenhcp.com]

  • Acute Leukemia

    Physical examination showed jaundice, hepatosplenomegaly, and peripheral facial nerve palsy in addition to dermal nodules.[ncbi.nlm.nih.gov] A 43-year-old female presented with leukocytosis and bicytopenia.[ncbi.nlm.nih.gov] Symptoms include anemia, fatigue, weight loss, easy bruising, thrombocytopenia, granulocytopenia with bacterial infections, bone pain, lymphadenopathy, hepatosplenomegaly,[medical-dictionary.thefreedictionary.com]

  • Thrombocytopenia

    All three affected siblings presented with SLE before the age of 3-years with lethargy, intermittent fever, thrombocytopenia, cutaneous involvement, alopecia, and hepatosplenomegaly[ncbi.nlm.nih.gov] HIV post exposure prophylaxis induced bicytopenia: a case report. AIDS Res Ther . 2014; 11 :11. [ PubMed ] [ DOI ] 8. Visentin GP , Liu CY.[wjgnet.com] It presents in infancy or in neonates (in severe cases) with patients bruising easily along with further manifestations of thrombocytopenia including epistaxis, petechiae,[enerca.org]

  • Pancytopenia

    Three of the 11 patients had severe thrombocytopenia, and they were admitted with complaints of epistaxis, gingival bleeding, petechiae, and purpura.[ncbi.nlm.nih.gov] We present case of two Syrian refugee infants with severe vitamin B12 deficiency with pancytopenia, hepatosplenomegaly and leukoerythroblastosis.[ncbi.nlm.nih.gov] […] of bicytopenia and pancytopenia.[ijpmonline.org]

  • Brucellosis

    Severe thrombocytopenia with bleeding is rarely reported in children with brucellosis, and recurrent epistaxis is extremely rare.[ncbi.nlm.nih.gov] Abstract Brucellosis is a systemic zoonotic infectious disease that may cause fever, fatigue, sweating, arthritis, hepatosplenomegaly, cytopenia, and lymphadenopathy.[ncbi.nlm.nih.gov] In this paper, we present a case of brucellosis with acute hepatitis and bicytopenia without anaemia.[ncbi.nlm.nih.gov]

  • Disseminated Intravascular Coagulation

    Still's disease is a rare inflammatory condition of unknown origin characterized by high spiking fever, arthralgia, arthritis, myalgia, salmon-colored evanescent rash, and hepatosplenomegaly[ncbi.nlm.nih.gov] […] bilateral periorbital oedema and tense orbits in keeping with orbital compartment syndrome (OCS) shortly after presenting to the emergency department for uncontrollable epistaxis[ncbi.nlm.nih.gov] Clinical history can include epistaxis, gingival bleeding, haematuria, oliguria, cough, dyspnoea, fever, delirium, and coma.[bestpractice.bmj.com]

  • Mantle Cell Lymphoma

    Most patients present with advanced stage disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement.[icd9data.com] Further investigation revealed bicytopenia with splenomegaly and elevated serum creatinine.[ncbi.nlm.nih.gov] Although thrombocytopenia was pronounced in patients treated with temsirolimus 175/75-mg and 175/25-mg and grade 1 or 2 epistaxis was observed in 35% and 24% of patients,[dx.doi.org]

  • Myelodysplasia

    Fewer than 20% of patients present with symptoms of isolated thrombocytopenia such as minor bleeding (eg, mucosal bleeding, petechiae, easy bruising, epistaxis) or major bleeding[mdedge.com] An 18-month-old boy presented with fever, hepatosplenomegaly, jaundice, pancytopenia, hyperferritinemia, hypertriglyceridemia and evidence of hemophagocytosis and trilineage[ncbi.nlm.nih.gov] 2017) Age – median is 65-70 Sex – M F Classification Classification of MDS, Subtypes Subtype Blood Bone Marrow MDS cytopenias with single lineage dysplasia Unicytopenia or bicytopenia[arupconsult.com]

  • Cytomegalovirus Infection

    […] should arouse suspicion of intrauterine CMV infection can be distinguished into CNS signs such as ventriculomegaly or microcephaly and extracerebral infection signs such as hepatosplenomegaly[ncbi.nlm.nih.gov] Laboratory investigations showed bicytopenia from complete blood count. Chest radiography and high-resolution computed tomography of the chest revealed lung nodules.[symbiosisonlinepublishing.com] […] and Procedures Patients with cytomegalovirus infection often receive corneal transplant , transurethral resection of prostate (turp) , coronary thrombolysis , control of epistaxis[symcat.com]

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