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100 Possible Causes for Bicytopenia, Hepatosplenomegaly

  • Familial Hemophagocytic Lymphohistiocytosis

    Reported here is the case of a 12-year-old boy, from a poor family, with a 6-year history of visual loss and fever for 5 months, and transient hemiparesis with hepatosplenomegaly[] Hemogram revealed bicytopenia and bone marrow aspirate showed hemophagocytosis.[] […] guidelines of the Histiocyte Society, diagnosis of Hemophagocytic Lympho-histiocytosis (HLH) requires fulfillment of 5 out of 8 criteria – prolonged fever, splenomegaly, bicytopenia[]

  • Gaucher Disease

    The hematologist is at the forefront of specialists to whom patients with Gaucher disease present because of cytopenia and hepatosplenomegaly.[] The phenotype was unusually severe with congenital ichthyosis, hepatosplenomegaly, muscular hypotonia, myoclonus and respiratory failure.[] The main clinical features include massive hepatosplenomegaly, anemia, thrombocytopenia and skeletal abnormalities such as avascular necrosisis and osteopenia.[]

  • Brucellosis

    Brucellosis is a systemic zoonotic infectious disease that may cause fever, fatigue, sweating, arthritis, hepatosplenomegaly, cytopenia, and lymphadenopathy.[] The diagnostic criteria include fever, hepatosplenomegaly, bicytopenia, high serum ferritin level, decreased natural killer cell activity, elevated soluble CD25 level, high[] On examination in an emergency room, abdomen palpation was normal with hepatosplenomegaly and the results of a liver function test were elevated.[]

  • Malaria

    A 5-year-old immunocompetent girl presented with fever, jaundice, hepatosplenomegaly and pancytopenia.[] The prevalence of cytopenias were; 29.6, 48.0% for anemia, 38.9, 12.0% for thrombocytopenia, 20.4, 12.0% for leukopenia, 13.0, 8.0% for bicytopenia and 5.6, 4.0% for pancytopenia[]

  • Extramedullary Hematopoiesis

    The main clinical manifestations of PMF are anemia, bleeding, hepatosplenomegaly, fatigue, and fever.[] A 58-year-old woman underwent workup for bicytopenia, and was diagnosed with MM based on the results of bone marrow aspiration and serum protein electrophoresis.[] Filgrastim was started at the fourth day of administration for severe neutropenia with fever; 3 days after the start of filgrastim, the patient experienced hepatosplenomegaly[]

  • Hypertriglyceridemia

    Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory condition characterized by fever, cytopenias, hepatosplenomegaly and hemophagocytosis.[] Lymphadenopathies, hepatosplenomegaly, and/or bleeding were absent.[] […] lead to specific symptoms: both familial chylomicronemia and primary mixed hyperlipidemia include skin symptoms (eruptive xanthoma ), eye abnormalities (lipemia retinalis), hepatosplenomegaly[]

  • Acute Leukemia

    Physical examination showed jaundice, hepatosplenomegaly, and peripheral facial nerve palsy in addition to dermal nodules.[] A 43-year-old female presented with leukocytosis and bicytopenia.[] Symptoms include anemia, fatigue, weight loss, easy bruising, thrombocytopenia, granulocytopenia with bacterial infections, bone pain, lymphadenopathy, hepatosplenomegaly,[]

  • Systemic Mastocytosis

    We report the case of a 48-year old male patient who presented with hepatosplenomegaly for 12 years, yellow-brown colored maculopapular pigmentation on the skin and pancytopenia[] Although the patient responded to the treatment, the relapse with splenomegaly and bicytopenia was observed after 10 months.[] We included 88 patients with ISM, of whom 9 developed new hepatosplenomegaly during follow-up.[]

  • Castleman Disease

    For multicentric disease: multi-region CT bilateral hilar and mediastinal lymphadenopathy centrilobular nodules diffuse abdominal lymphadenopathy hepatosplenomegaly ascites[] Investigations showed bicytopenia, nephrotic range proteinuria with hypoalbuminemia, hypogammaglobulinemia, and features of hyaline-vascular type Castleman disease in a lymph[] […] in the groin , neck , or armpit Unintentional loss of weight In some cases fever and weakness Easy fatigue Appetite loss or extremely poor appetite Lymph node enlargement Hepatosplenomegaly[]

  • African Histoplasmosis

    On clinical examination, neither hepatosplenomegaly nor lymphadenopathy was found. Examination of other systems revealed no significant abnormality.[] Moreover, the patient presented with normochromic normocytic anemia (hemoglobin at 10.8g/dl), bicytopenia (leukocytes at 2,200/mm 3 , red blood cells at 2,840,000/mm 3 ),[] The most common physical findings include rales, hepatosplenomegaly and lymphadenopathy.[]

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