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41 Possible Causes for Bicytopenia, Hepatosplenomegaly, Leukocytes Decreased

  • Gaucher Disease

    We report here the case of a young woman with hepatosplenomegaly, leukopenia, and thrombocytopenia.[ncbi.nlm.nih.gov] All patients were diagnosed with GD based on decreased GBA activity in peripheral leukocytes or on genetic testing.[ncbi.nlm.nih.gov] Abstract The hematologist is at the forefront of specialists to whom patients with Gaucher disease present because of cytopenia and hepatosplenomegaly.[ncbi.nlm.nih.gov]

  • Follicular Lymphoma

    Splenomegaly is present in approximately 50% of patients at presentation, and hepatosplenomegaly may occur.[emedicine.com] In addition, the presence of an autoimmune bicytopenia and a Klinefelter syndrome complicated the clinical context of the patient.[ncbi.nlm.nih.gov] […] examination revealed significant axillary and inguinal adenopathy (node size, 1.0 cm), and radiological examination (computed tomography scan and ultrasonography) showed hepatosplenomegaly[nature.com]

  • Acute Myelocytic Leukemia

    In all three patients, radionuclide imaging with technetium-99m sulfur colloid showed hepatosplenomegaly, decreased liver uptake, and increased splenic activity.[ncbi.nlm.nih.gov] In contrast to patients with RA and only dyserythropoiesis, patients with multilineage dysplasia have bicytopenia or pancytopenia, a higher incidence of cytogenetic abnormalities[bloodjournal.hematologylibrary.org] Symptoms include anemia, fatigue, weight loss, easy bruising, thrombocytopenia, granulocytopenia with bacterial infections, bone pain, lymphadenopathy, hepatosplenomegaly,[medical-dictionary.thefreedictionary.com]

  • Brucellosis

    Abstract Brucellosis is a systemic zoonotic infectious disease that may cause fever, fatigue, sweating, arthritis, hepatosplenomegaly, cytopenia, and lymphadenopathy.[ncbi.nlm.nih.gov] In this paper, we present a case of brucellosis with acute hepatitis and bicytopenia without anaemia.[ncbi.nlm.nih.gov] The diagnostic criteria include fever, hepatosplenomegaly, bicytopenia, high serum ferritin level, decreased natural killer cell activity, elevated soluble CD25 level, high[ncbi.nlm.nih.gov]

  • Systemic Mastocytosis

    We report the case of a 48-year old male patient who presented with hepatosplenomegaly for 12 years, yellow-brown colored maculopapular pigmentation on the skin and pancytopenia[sciforschenonline.org] Although the patient responded to the treatment, the relapse with splenomegaly and bicytopenia was observed after 10 months.[ncbi.nlm.nih.gov] RESULTS: We included 88 patients with ISM, of whom 9 developed new hepatosplenomegaly during follow-up.[ncbi.nlm.nih.gov]

  • Chronic Myelomonocytic Leukemia

    Affected individuals present with monocytosis, cytopenias, and extramedullary manifestations like lymphadenopathy and hepatosplenomegaly.[symptoma.com] In contrast to patients with RA and only dyserythropoiesis, patients with multilineage dysplasia have bicytopenia or pancytopenia, a higher incidence of cytogenetic abnormalities[doi.org] After the start of vaccination, the leukocyte and monocyte counts (13,780/microL and 1930/microL, respectively) gradually decreased to within the normal range in association[ncbi.nlm.nih.gov]

  • Severe Aplastic Anemia

    […] with aplastic anemia present with jaundice and evidence of clinical hepatitis. [1, 2] Findings of adenopathy or organomegaly should suggest an alternative diagnosis (eg, hepatosplenomegaly[emedicine.medscape.com] […] transplantation (SCT) can be curative for patients with severe aplastic anemia (SAA). 1 , 2 Concerns about graft failure and graft-versus-host disease (GVHD), more so for human leukocyte[nature.com] The introduction of post-SCT cyclophosphamide (PTCy) has been shown to decrease alloreactivity in the host-versus-graft and graft-versus-host directions and could be particularly[nature.com]

  • Adenovirus Infection

    […] pneumonia, encephalopathy, myocarditis, rash) was diagnosed with adenovirus-associated macrophage activation syndrome according to clinical and laboratory parameters (fever, hepatosplenomegaly[ncbi.nlm.nih.gov] […] encephalopathy, myocarditis, rash) was diagnosed with adenovirus-associated macrophage activation syndrome according to clinical and laboratory parameters (fever, hepatosplenomegaly, bicytopenia[ncbi.nlm.nih.gov]

  • Hepatosplenic T-cell Lymphoma

    We report a case of a man presenting with an unexplained fever, pancytopenia and hepatosplenomegaly without lymphadenopathy.[ncbi.nlm.nih.gov] There was bicytopenia (hemoglobin - 101 g/L, platelet count - 38 10 9 /L, and total leukocyte count - 5 10 9 /L) with only a few blasts in peripheral blood film [Figure 1][ijpmonline.org] Initial blood work showed mild pancytopaenia and imaging studies revealed hepatosplenomegaly.[ncbi.nlm.nih.gov]

  • Pancytopenia

    We present case of two Syrian refugee infants with severe vitamin B12 deficiency with pancytopenia, hepatosplenomegaly and leukoerythroblastosis.[ncbi.nlm.nih.gov] […] of bicytopenia and pancytopenia.[ijpmonline.org] See Fanconi's disease. pan·cy·to·pe·ni·a ( pan'sī-tō-pē'nē-ă ) Pronounced reduction in the number of erythrocytes, all types of leukocytes, and the blood platelets in the[medical-dictionary.thefreedictionary.com]

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