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10 Possible Causes for Bicytopenia, Hepatosplenomegaly, Lysozyme Increased

  • Gaucher Disease

    We report here the case of a young woman with hepatosplenomegaly, leukopenia, and thrombocytopenia.[ncbi.nlm.nih.gov] Abstract The hematologist is at the forefront of specialists to whom patients with Gaucher disease present because of cytopenia and hepatosplenomegaly.[ncbi.nlm.nih.gov] [ncbi.nlm.nih.gov] Less common signs of the disease are hepatosplenomegaly, ichthyosis, arthrogryposis and facial dysmorphy.[symptoma.com]

  • Acute Leukemia

    Serum and urine levels of muramidase (lysozyme) are usually elevated because of the monocytic proliferation.[intechopen.com] Physical examination showed jaundice, hepatosplenomegaly, and peripheral facial nerve palsy in addition to dermal nodules.[ncbi.nlm.nih.gov] A 43-year-old female presented with leukocytosis and bicytopenia.[ncbi.nlm.nih.gov]

  • Acute Myelocytic Leukemia

    Diagnosis Aides: High serum lysozyme (3x normal) A peripheral monocytosis of 5x 10 /L in an otherwise M2 marrow and increased lysozyme A peripheral monocytosis of 5 x 10 [med-ed.virginia.edu] In all three patients, radionuclide imaging with technetium-99m sulfur colloid showed hepatosplenomegaly, decreased liver uptake, and increased splenic activity.[ncbi.nlm.nih.gov] In contrast to patients with RA and only dyserythropoiesis, patients with multilineage dysplasia have bicytopenia or pancytopenia, a higher incidence of cytogenetic abnormalities[bloodjournal.hematologylibrary.org]

  • Primary Myelofibrosis

    The main clinical manifestations of PMF are anemia, bleeding, hepatosplenomegaly, fatigue, and fever.[ncbi.nlm.nih.gov] Patients with primary myelofibrosis may have pancytopenia or bicytopenia and in that respect mimic patients with oligoblastic leukemia (myelodysplasia [MDS]; see Chap. 88)[patient-help.com] Most of them had anemia, fever, and hepatosplenomegaly on admission.[ncbi.nlm.nih.gov]

  • Chronic Myelomonocytic Leukemia

    […] production and excretion of lysozyme were reported. 3 , 7 The combination of interstitial inflammation, tubulitis, and degenerative tubular changes in the absence of vascular[dovepress.com] Affected individuals present with monocytosis, cytopenias, and extramedullary manifestations like lymphadenopathy and hepatosplenomegaly.[symptoma.com] In contrast to patients with RA and only dyserythropoiesis, patients with multilineage dysplasia have bicytopenia or pancytopenia, a higher incidence of cytogenetic abnormalities[doi.org]

  • Acute Megakaryocytic Leukemia

    Diagnosis Aides: High serum lysozyme (3x normal) A peripheral monocytosis of 5x 10 /L in an otherwise M2 marrow and increased lysozyme A peripheral monocytosis of 5 x 10 [med-ed.virginia.edu] The results indicated that the fever, hemorrhage, hepatosplenomegaly and lymphadenopathy in this case were the primary presentations accompanying by leukocytosis, anemia and[ncbi.nlm.nih.gov] The patient’s medical history was consistent with intermittent low-grade fever associated with bicytopenia (neutropenia and thrombocytopenia) for the last 3 years.[dovepress.com]

  • Refractory Anemia

    IMMUNOHISTOCHEMISTRY: Reticulin fibrosis is not increased.[gpec.ubc.ca] Hepatosplenomegaly and marked retroperitoneal lymphadenopathy were revealed, indicating further dissemination of MAI.[ncbi.nlm.nih.gov] Diagnosis Comment: There is leukocytosis and bicytopenia (normocytic anemia and thrombocytopenia).[gpec.ubc.ca]

  • Lymphopenic Agammaglobulinemia - Short-Limbed Dwarfism Syndrome

    Increased intramedullary destruction of neutrophils with elevated serum lysozyme levels is part of the clinical spectrum.[musculoskeletalkey.com] […] meningitis, mental retardation, headache lymphatic splenomegaly, occasional lymphadenopathy splenomegaly, occasional lymphadenopathy cervical adenopathy in children not seen rare hepatosplenomegaly[ufrgs.br] Copper deficiency can cause neutropenia in patients on total parenteral nutrition, with a history of gastrectomy, and in malnourished children 86, 87, 88 and the bicytopenia[oncohemakey.com]

  • Acute Panmyelosis with Myelofibrosis

    Sequential BM biopsies revealed an accumulation of lysozyme-expressing myelomonocytic and CD34 progenitor cells suggesting an increase in blasts.[ncbi.nlm.nih.gov] On ultrasonographic examination, no evidence of hepatosplenomegaly or any other abnormalities were noted.[portal.koreascience.or.kr] ) Anemia Blasts 1% Erythroid dysplasia only Blasts 5% Ringsideroblasts ³ 15% (count on erythroblasts) Refractory cytopenia with multilineage dysplasia (RCMD) Cytopenias (bicytopenia[w1.uzleuven.be]

  • Acute Erythroblastic Leukemia

    Diagnosis Aides: High serum lysozyme (3x normal) A peripheral monocytosis of 5x 10 /L in an otherwise M2 marrow and increased lysozyme A peripheral monocytosis of 5 x 10 [med-ed.virginia.edu] Guglielmo syndrome Hematology An acute myelocytic leukemia–FAB classification, M6, which is usually acquired affecting the elderly, but rarely also AD Clinical Anemia, fever, hepatosplenomegaly[medical-dictionary.thefreedictionary.com] The initial diagnoses were chronic myeloid leukemia in two, myelodysplastic syndrome in nine including four cases of Down syndrome, pancytopenia or bicytopenia in three, and[jstage.jst.go.jp]

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