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29 Possible Causes for Bicytopenia, Hepatosplenomegaly, Monocyte Count Increased

  • Gaucher Disease

    We report here the case of a young woman with hepatosplenomegaly, leukopenia, and thrombocytopenia.[] [] Less common signs of the disease are hepatosplenomegaly, ichthyosis, arthrogryposis and facial dysmorphy.[] Laboratory studies that show anemia and other hematological abnormalities, together with marked hepatosplenomegaly will usually indicate a bone marrow biopsy, which will show[]

  • Acute Leukemia

    The leukocyte count is usually increased monocytic cells (monoblast, promoncytes, monocytes), are increased to 5000/L or more.[] Physical examination showed jaundice, hepatosplenomegaly, and peripheral facial nerve palsy in addition to dermal nodules.[] A 43-year-old female presented with leukocytosis and bicytopenia.[]

  • Acute Myelocytic Leukemia

    JMML characteristically presents with hepatosplenomegaly, lymphadenopathy, fever, and skin rash along with an elevated white blood cell (WBC) count and increased circulating[] In all three patients, radionuclide imaging with technetium-99m sulfur colloid showed hepatosplenomegaly, decreased liver uptake, and increased splenic activity.[] In contrast to patients with RA and only dyserythropoiesis, patients with multilineage dysplasia have bicytopenia or pancytopenia, a higher incidence of cytogenetic abnormalities[]

  • Brucellosis

    Abstract Brucellosis is a systemic zoonotic infectious disease that may cause fever, fatigue, sweating, arthritis, hepatosplenomegaly, cytopenia, and lymphadenopathy.[] In this paper, we present a case of brucellosis with acute hepatitis and bicytopenia without anaemia.[] On examination in an emergency room, abdomen palpation was normal with hepatosplenomegaly and the results of a liver function test were elevated.[]

  • Autoimmune Hemolytic Anemia

    A 7-month-old boy, presented with prolonged fever, erythematous rash, severe pallor and hepatosplenomegaly.[] Autoimmune bicytopenia in pulmonary tuberculosis. Report of a pediatric case. Respir Med CME 2008;1:281-3. 9. Safe IP, O'brien C, Ferreira FR, Souza ML, Ramasawmy R.[] Computed tomography (CT) of the chest, abdomen and pelvis was remarkable for hepatosplenomegaly.[]

  • Chronic Myelomonocytic Leukemia

    The Mayo prognostic model classified CMML patients into three risk groups based on: increased absolute monocyte count, presence of circulating blasts, hemoglobin 9 /L.[] Affected individuals present with monocytosis, cytopenias, and extramedullary manifestations like lymphadenopathy and hepatosplenomegaly.[] In contrast to patients with RA and only dyserythropoiesis, patients with multilineage dysplasia have bicytopenia or pancytopenia, a higher incidence of cytogenetic abnormalities[]

  • Disseminated Tuberculosis

    Disseminated tuberculosis can present in various ways including prolonged fever / pyrexia of unknown origin, hepatosplenomegaly, lymphadenopathy, meningitis and rarely extreme[] Patients and Methods 312 bone marrow aspirates from patients with the diagnosis of anaemia, severe granulocytopenia, thrombocytopenia, bicytopenia or pancytopenia, referred[] Clinical examination revealed diffuse macular rash, severe pallor, deep icterus, generalised lymphadenopathy and hepatosplenomegaly.[]

  • Leukoerythroblastic Anemia

    Peripheral blood monocytes, fibrous tissue and cellularity in bone marrow are increased in MDS (22, 23).[] Usually there is hepatosplenomegaly due to myeloid metaplasia in which, in addition to leukoblastic cells, erythroblasts are constantly prominent and giant cells[] Pancytopenia was seen in 9.55% (17) cases and bicytopenia in 50.5% (90) patients.[]

  • Acute Megakaryocytic Leukemia

    Leucocytosis is present in 30–50 % of cases of TAM and typically includes increased neutrophils, myelocytes, monocytes and basophils [ 11 ••, 31, 33 ••].[] The results indicated that the fever, hemorrhage, hepatosplenomegaly and lymphadenopathy in this case were the primary presentations accompanying by leukocytosis, anemia and[] The patient’s medical history was consistent with intermittent low-grade fever associated with bicytopenia (neutropenia and thrombocytopenia) for the last 3 years.[]

  • Lymphopenic Agammaglobulinemia - Short-Limbed Dwarfism Syndrome

    […] and normal or increased blood monocyte counts and immunoglobulin levels.[] […] meningitis, mental retardation, headache lymphatic splenomegaly, occasional lymphadenopathy splenomegaly, occasional lymphadenopathy cervical adenopathy in children not seen rare hepatosplenomegaly[] Copper deficiency can cause neutropenia in patients on total parenteral nutrition, with a history of gastrectomy, and in malnourished children 86, 87, 88 and the bicytopenia[]

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