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56 Possible Causes for Bicytopenia, Hepatosplenomegaly, Petechiae

  • Acute Leukemia

    Physical examination showed jaundice, hepatosplenomegaly, and peripheral facial nerve palsy in addition to dermal nodules.[ncbi.nlm.nih.gov] A 43-year-old female presented with leukocytosis and bicytopenia.[ncbi.nlm.nih.gov] […] infection because there are a decreased number of healthy white blood cells , known as neutropenia Bruising or bleeding from decreased platelets, known as thrombocytopenia Petechiae[curesearch.org]

  • Primary Myelofibrosis

    The main clinical manifestations of PMF are anemia, bleeding, hepatosplenomegaly, fatigue, and fever.[ncbi.nlm.nih.gov] Patients with primary myelofibrosis may have pancytopenia or bicytopenia and in that respect mimic patients with oligoblastic leukemia (myelodysplasia [MDS]; see Chap. 88)[patient-help.com] Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy[orpha.net]

  • Acute Myelocytic Leukemia

    In all three patients, radionuclide imaging with technetium-99m sulfur colloid showed hepatosplenomegaly, decreased liver uptake, and increased splenic activity.[ncbi.nlm.nih.gov] In contrast to patients with RA and only dyserythropoiesis, patients with multilineage dysplasia have bicytopenia or pancytopenia, a higher incidence of cytogenetic abnormalities[bloodjournal.hematologylibrary.org] Thrombocytopenia often causes petechiae on the lower limbs. DIC may aggravate the situation and cause larger lesions.[patient.info]

  • Gaucher Disease

    We report here the case of a young woman with hepatosplenomegaly, leukopenia, and thrombocytopenia.[ncbi.nlm.nih.gov] […] massive), and bone involvement (bone pain due to bone infarcts or pathological fractures due to osteopenia) and may bruise easily or present with nosebleeds, bruising and petechiae[patient.info] Abstract The hematologist is at the forefront of specialists to whom patients with Gaucher disease present because of cytopenia and hepatosplenomegaly.[ncbi.nlm.nih.gov]

  • Familial Hemophagocytic Lymphohistiocytosis

    Reported here is the case of a 12-year-old boy, from a poor family, with a 6-year history of visual loss and fever for 5 months, and transient hemiparesis with hepatosplenomegaly[ncbi.nlm.nih.gov] Hemogram revealed bicytopenia and bone marrow aspirate showed hemophagocytosis.[link.springer.com] […] guidelines of the Histiocyte Society, diagnosis of Hemophagocytic Lympho-histiocytosis (HLH) requires fulfillment of 5 out of 8 criteria – prolonged fever, splenomegaly, bicytopenia[indianpediatrics.net]

  • Chronic Myeloid Leukemia

    Due to presenting complaint of bleeding diathesis and absence of hepatosplenomegaly, the case was undiagnosed for CML until the patient reported to us.[ncbi.nlm.nih.gov] In contrast to patients with RA and only dyserythropoiesis, patients with multilineage dysplasia have bicytopenia or pancytopenia, a higher incidence of cytogenetic abnormalities[doi.org] […] include: Bruising Excessive sweating (night sweats) Fatigue Fever Pressure under the lower left ribs from a swollen spleen Rash -- small pinpoint red marks on the skin ( petechiae[medlineplus.gov]

  • Chronic Myelomonocytic Leukemia

    Affected individuals present with monocytosis, cytopenias, and extramedullary manifestations like lymphadenopathy and hepatosplenomegaly.[symptoma.com] In contrast to patients with RA and only dyserythropoiesis, patients with multilineage dysplasia have bicytopenia or pancytopenia, a higher incidence of cytogenetic abnormalities[doi.org] Case 1 was a 61-year-old female patient admitted to our hospital because of skin petechiae and purpura for 6 days.[ncbi.nlm.nih.gov]

  • Severe Aplastic Anemia

    […] with aplastic anemia present with jaundice and evidence of clinical hepatitis. [1, 2] Findings of adenopathy or organomegaly should suggest an alternative diagnosis (eg, hepatosplenomegaly[emedicine.medscape.com] An 8-year-old girl was admitted with fever, myalgia and petechiae. Dengue virus IgM antibodies were positive.[ncbi.nlm.nih.gov] The intraoral examination identified bleeding gums; petechiae of the palate, tongue and cheek mucosa; and an atrophic, smooth and shining dorsal surface of the tongue.[ncbi.nlm.nih.gov]

  • Autoimmune Lymphoproliferative Syndrome

    Patients with ALPS can develop a myriad of clinical manifestations including lymphadenopathy, hepatosplenomegaly, autoimmunity and increased rates of malignancy.[ncbi.nlm.nih.gov] […] hepatitis, vasculitis, arthritis and central nervous system involvement (seizures, headache, encephalopathy). [5] Our patient had nonmalignant enlargement of lymph nodes, and bicytopenia[ijpd.in] Little red spots called petechiae may show up on the skin, and some patients have skin rashes. The spleen, lymph nodes, and liver may be enlarged.[empowher.com]

  • Thrombocytopenia

    All three affected siblings presented with SLE before the age of 3-years with lethargy, intermittent fever, thrombocytopenia, cutaneous involvement, alopecia, and hepatosplenomegaly[ncbi.nlm.nih.gov] HIV post exposure prophylaxis induced bicytopenia: a case report. AIDS Res Ther . 2014; 11 :11. [ PubMed ] [ DOI ] 8. Visentin GP , Liu CY.[wjgnet.com] A 20-month-old boy presented with a 2-day history of fever and systemic petechiae.[ncbi.nlm.nih.gov]

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