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68 Possible Causes for Bicytopenia, Hepatosplenomegaly, Seizure

  • Gaucher Disease

    We report here the case of a young woman with hepatosplenomegaly, leukopenia, and thrombocytopenia.[ncbi.nlm.nih.gov] T y pe 2 Gaucher disease (acute infantile neuropathic Gaucher disease) symptoms usually begin by 3 months of age and includes extensive brain damage, seizures, spasticity,[ninds.nih.gov] Patients with this type may present at birth or during infancy with increased tone, seizures, strabismus, and organomegaly.[emedicine.medscape.com]

  • Familial Hemophagocytic Lymphohistiocytosis

    Reported here is the case of a 12-year-old boy, from a poor family, with a 6-year history of visual loss and fever for 5 months, and transient hemiparesis with hepatosplenomegaly[ncbi.nlm.nih.gov] Hemogram revealed bicytopenia and bone marrow aspirate showed hemophagocytosis.[link.springer.com] This disorder can affect multiple organ systems, and neurologic manifestations include irritability, seizures, impaired consciousness, meningismus, and cranial nerve palsies[ncbi.nlm.nih.gov]

  • Primary Myelofibrosis

    The main clinical manifestations of PMF are anemia, bleeding, hepatosplenomegaly, fatigue, and fever.[ncbi.nlm.nih.gov] Patients with primary myelofibrosis may have pancytopenia or bicytopenia and in that respect mimic patients with oligoblastic leukemia (myelodysplasia [MDS]; see Chap. 88)[patient-help.com] Extramedullary hematopoiesis may involve any organ and may result in gastrointestinal bleeding, spinal cord compression, seizures, haemoptysis, and/or effusions.[patient.info]

  • Cytomegalovirus Infection

    […] should arouse suspicion of intrauterine CMV infection can be distinguished into CNS signs such as ventriculomegaly or microcephaly and extracerebral infection signs such as hepatosplenomegaly[ncbi.nlm.nih.gov] Laboratory investigations showed bicytopenia from complete blood count. Chest radiography and high-resolution computed tomography of the chest revealed lung nodules.[symbiosisonlinepublishing.com] While receiving antiviral and corticosteroid therapy, the patient developed seizures related to a cerebral vasculitis.[ncbi.nlm.nih.gov]

  • Pancytopenia

    We present case of two Syrian refugee infants with severe vitamin B12 deficiency with pancytopenia, hepatosplenomegaly and leukoerythroblastosis.[ncbi.nlm.nih.gov] […] of bicytopenia and pancytopenia.[ijpmonline.org] She had been taking valproic acid, due to a previous episode of epileptic seizures, and presented with drowsiness and dizziness.[ncbi.nlm.nih.gov]

  • Disseminated Intravascular Coagulation

    Still's disease is a rare inflammatory condition of unknown origin characterized by high spiking fever, arthralgia, arthritis, myalgia, salmon-colored evanescent rash, and hepatosplenomegaly[ncbi.nlm.nih.gov] Treatment of seizures Treatment of seizures depends on the underlying disorder causing the DIC.[epilepsy.com] Although one episode of seizures was noted, electroencephalogram was normal.[ncbi.nlm.nih.gov]

  • Mantle Cell Lymphoma

    Most patients present with advanced stage disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement.[icd9data.com] Further investigation revealed bicytopenia with splenomegaly and elevated serum creatinine.[ncbi.nlm.nih.gov] […] bladder, breast) unless disease free for at least 3 years, known infection with HIV or hepatitis B or C virus, metastases in cerebrospinal fluid or brain, and a history of a seizure[mdedge.com]

  • Acute Leukemia

    Physical examination showed jaundice, hepatosplenomegaly, and peripheral facial nerve palsy in addition to dermal nodules.[ncbi.nlm.nih.gov] A 43-year-old female presented with leukocytosis and bicytopenia.[ncbi.nlm.nih.gov] If this happens, the patient may have neurological symptoms, such as dizziness, vomiting, blurred vision, fits (seizures), and headaches.[medicalnewstoday.com]

  • Castleman Disease

    For multicentric disease: multi-region CT bilateral hilar and mediastinal lymphadenopathy centrilobular nodules diffuse abdominal lymphadenopathy hepatosplenomegaly ascites[radiopaedia.org] Investigations showed bicytopenia, nephrotic range proteinuria with hypoalbuminemia, hypogammaglobulinemia, and features of hyaline-vascular type Castleman disease in a lymph[ncbi.nlm.nih.gov] A 30-year-old man presented with a generalized tonic-clonic seizure.[ncbi.nlm.nih.gov]

  • Follicular Lymphoma

    Splenomegaly is present in approximately 50% of patients at presentation, and hepatosplenomegaly may occur.[emedicine.com] In addition, the presence of an autoimmune bicytopenia and a Klinefelter syndrome complicated the clinical context of the patient.[ncbi.nlm.nih.gov] Malformation Coma/Level of Consciousness Demyelinating Disease Dermatome Map Functional Outcome Head & Neck Trauma Headache Intracerebral Hemorrhage Ischemic Stroke Neurophysiology Seizure[qxmd.com]

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