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24 Possible Causes for Bicytopenia, Hepatosplenomegaly, Splenic Infarction

  • Gaucher Disease

    We report here the case of a young woman with hepatosplenomegaly, leukopenia, and thrombocytopenia.[ncbi.nlm.nih.gov] […] nodules (30%) 1 splenic infarcts (33%) liver hepatomegaly : less marked than the degree of splenomegaly T2 : hyperintense stellate areas representing inflammation and fibrosis[radiopaedia.org] infarcts are common; - pancytopenia w/ severe thrombocytopenia is seen; - splenectomy offers temporary relief but pancytopenia may recur w/ depletion of the normal marrow[wheelessonline.com]

  • Primary Myelofibrosis

    The main clinical manifestations of PMF are anemia, bleeding, hepatosplenomegaly, fatigue, and fever.[ncbi.nlm.nih.gov] Patients with primary myelofibrosis may have pancytopenia or bicytopenia and in that respect mimic patients with oligoblastic leukemia (myelodysplasia [MDS]; see Chap. 88)[patient-help.com] Splenic infarction: usually self-limited and treated with fluids and opiate analgesics. Refractory cases may require splenectomy or splenic irradiation.[patient.info]

  • Acute Leukemia

    Physical examination showed jaundice, hepatosplenomegaly, and peripheral facial nerve palsy in addition to dermal nodules.[ncbi.nlm.nih.gov] A 43-year-old female presented with leukocytosis and bicytopenia.[ncbi.nlm.nih.gov] Symptoms include anemia, fatigue, weight loss, easy bruising, thrombocytopenia, granulocytopenia with bacterial infections, bone pain, lymphadenopathy, hepatosplenomegaly,[medical-dictionary.thefreedictionary.com]

  • Chronic Myeloid Leukemia

    Due to presenting complaint of bleeding diathesis and absence of hepatosplenomegaly, the case was undiagnosed for CML until the patient reported to us.[ncbi.nlm.nih.gov] In contrast to patients with RA and only dyserythropoiesis, patients with multilineage dysplasia have bicytopenia or pancytopenia, a higher incidence of cytogenetic abnormalities[doi.org] Splenectomy may be done for palliation in patients with late stage CML complaining of pain and discomfort due to the enlarged spleen and splenic infarcts.[lecturio.com]

  • Acute Myelocytic Leukemia

    In all three patients, radionuclide imaging with technetium-99m sulfur colloid showed hepatosplenomegaly, decreased liver uptake, and increased splenic activity.[ncbi.nlm.nih.gov] In contrast to patients with RA and only dyserythropoiesis, patients with multilineage dysplasia have bicytopenia or pancytopenia, a higher incidence of cytogenetic abnormalities[dx.doi.org] Symptoms include anemia, fatigue, weight loss, easy bruising, thrombocytopenia, granulocytopenia with bacterial infections, bone pain, lymphadenopathy, hepatosplenomegaly,[medical-dictionary.thefreedictionary.com]

  • Acute Erythroblastic Leukemia

    Guglielmo syndrome Hematology An acute myelocytic leukemia–FAB classification, M6, which is usually acquired affecting the elderly, but rarely also AD Clinical Anemia, fever, hepatosplenomegaly[medical-dictionary.thefreedictionary.com] The initial diagnoses were chronic myeloid leukemia in two, myelodysplastic syndrome in nine including four cases of Down syndrome, pancytopenia or bicytopenia in three, and[jstage.jst.go.jp] Symptoms include anemia, fatigue, weight loss, easy bruising, thrombocytopenia, granulocytopenia with bacterial infections, bone pain, lymphadenopathy, hepatosplenomegaly,[medical-dictionary.thefreedictionary.com]

  • Brucellosis

    Abstract Brucellosis is a systemic zoonotic infectious disease that may cause fever, fatigue, sweating, arthritis, hepatosplenomegaly, cytopenia, and lymphadenopathy.[ncbi.nlm.nih.gov] In this paper, we present a case of brucellosis with acute hepatitis and bicytopenia without anaemia.[ncbi.nlm.nih.gov] Brucellosis and associated splenic infarct have rarely been studied, there being few cases in the literature.[ncbi.nlm.nih.gov]

  • Hepatosplenic Lymphoma

    Computed tomography scans and sonography solely displayed a marginal hepatosplenomegaly.[annonc.oxfordjournals.org] There was bicytopenia (hemoglobin - 101 g/L, platelet count - 38 10 9 /L, and total leukocyte count - 5 10 9 /L) with only a few blasts in peripheral blood film [Figure 1][ijpmonline.org] Complications Hepatomegaly Hepatic failure Portal vein thrombosis Splenomegaly Splenic infarction Spleen rupture Splenic vein thrombosis Anemia Thrombocytopenia Neutropenia[wikidoc.org]

  • Cytomegalovirus Infection

    […] should arouse suspicion of intrauterine CMV infection can be distinguished into CNS signs such as ventriculomegaly or microcephaly and extracerebral infection signs such as hepatosplenomegaly[ncbi.nlm.nih.gov] Laboratory investigations showed bicytopenia from complete blood count. Chest radiography and high-resolution computed tomography of the chest revealed lung nodules.[symbiosisonlinepublishing.com] Rarely, complications may develop which include hemolytic anemia, splenic infarction, interstitial pneumonia, thrombocytopenia, Guillain-Barre syndrome, meningoencephalitis[renalandurologynews.com]

  • African Histoplasmosis

    Severe infections can cause hepatosplenomegaly, lymphadenopathy, and adrenal enlargement. Lesions have a tendency to calcify as they heal.[en.wikipedia.org] Moreover, the patient presented with normochromic normocytic anemia (hemoglobin at 10.8g/dl), bicytopenia (leukocytes at 2,200/mm 3, red blood cells at 2,840,000/mm 3 ), and[omicsonline.org] Curr-Rheumatol-Rep. 2002 Feb; 4(1): 7-8 Papaioannides,-D; Nikas,-S-N; Fotinou,-M; Akritidis,-N-K Asymptomatic splenic infarction in Wegener's granulomatosis.[malattierare.regione.veneto.it]

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