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61 Possible Causes for Bicytopenia, Hepatosplenomegaly, Tachycardia

  • Acute Leukemia

    Physical examination showed jaundice, hepatosplenomegaly, and peripheral facial nerve palsy in addition to dermal nodules.[ncbi.nlm.nih.gov] A 43-year-old female presented with leukocytosis and bicytopenia.[ncbi.nlm.nih.gov] Physical examination Common features in a patient with ALL or AML may include fever, signs of anemia (eg. pallor, tachycardia), petechiae, ecchymosis and adenopathy.[symptoma.com]

  • Primary Myelofibrosis

    Dyspnea, tachycardia and dizziness are experienced in case of severe anemia.[symptoma.com] The main clinical manifestations of PMF are anemia, bleeding, hepatosplenomegaly, fatigue, and fever.[ncbi.nlm.nih.gov] Patients with primary myelofibrosis may have pancytopenia or bicytopenia and in that respect mimic patients with oligoblastic leukemia (myelodysplasia [MDS]; see Chap. 88)[patient-help.com]

  • Acute Myelocytic Leukemia

    When erythrocytes are affected (the most common situation), patients present with signs of anemia, including pallor, pale conjunctiva, tachycardia, hypotension, fatigue, headache[doi.org] In all three patients, radionuclide imaging with technetium-99m sulfur colloid showed hepatosplenomegaly, decreased liver uptake, and increased splenic activity.[ncbi.nlm.nih.gov] In contrast to patients with RA and only dyserythropoiesis, patients with multilineage dysplasia have bicytopenia or pancytopenia, a higher incidence of cytogenetic abnormalities[bloodjournal.hematologylibrary.org]

  • Autoimmune Hemolytic Anemia

    Physical findings are related to the degree of anemia and include pallor, resting tachycardia, mild jaundice and occasionally fever.[clinlabnavigator.com] A 7-month-old boy, presented with prolonged fever, erythematous rash, severe pallor and hepatosplenomegaly.[ncbi.nlm.nih.gov] Autoimmune bicytopenia in pulmonary tuberculosis. Report of a pediatric case. Respir Med CME 2008;1:281-3. 9. Safe IP, O'brien C, Ferreira FR, Souza ML, Ramasawmy R.[jahjournal.org]

  • Gaucher Disease

    We report here the case of a young woman with hepatosplenomegaly, leukopenia, and thrombocytopenia.[ncbi.nlm.nih.gov] […] symptoms including chest discomfort, conjunctival injection, dyspnea, generalized and itchy rash, hyperemia, swelling of eyelids, rhinorrhea, severe respiratory distress, tachycardia[aetna.com] Abstract The hematologist is at the forefront of specialists to whom patients with Gaucher disease present because of cytopenia and hepatosplenomegaly.[ncbi.nlm.nih.gov]

  • Chronic Myeloid Leukemia

    Due to presenting complaint of bleeding diathesis and absence of hepatosplenomegaly, the case was undiagnosed for CML until the patient reported to us.[ncbi.nlm.nih.gov] In contrast to patients with RA and only dyserythropoiesis, patients with multilineage dysplasia have bicytopenia or pancytopenia, a higher incidence of cytogenetic abnormalities[doi.org] On physical examination, we observed tachycardia, altered mental status, and dehydration.[ncbi.nlm.nih.gov]

  • Brucellosis

    Abstract Brucellosis is a systemic zoonotic infectious disease that may cause fever, fatigue, sweating, arthritis, hepatosplenomegaly, cytopenia, and lymphadenopathy.[ncbi.nlm.nih.gov] In this paper, we present a case of brucellosis with acute hepatitis and bicytopenia without anaemia.[ncbi.nlm.nih.gov] The diagnostic criteria include fever, hepatosplenomegaly, bicytopenia, high serum ferritin level, decreased natural killer cell activity, elevated soluble CD25 level, high[ncbi.nlm.nih.gov]

  • Severe Aplastic Anemia

    Symptoms include fatigue, pale skin, fast heartbeat (tachycardia), trouble breathing, chills, backache, and yellow skin ( jaundice ).[webmd.com] […] with aplastic anemia present with jaundice and evidence of clinical hepatitis. [1, 2] Findings of adenopathy or organomegaly should suggest an alternative diagnosis (eg, hepatosplenomegaly[emedicine.medscape.com] Patients may report tachycardia, palpitations and dyspnea, particularly when under exercise. They may appear cyanotic.[symptoma.com]

  • Disseminated Histoplasmosis

    Examination findings included resting tachycardia and melenic stool. Blood pressure was 95/50 mm Hg.[consultant360.com] The patient in the present case report was immunocompetent child and had fever, bone pains, gradual weight loss, lymphadenopathy and hepatosplenomegaly.[ncbi.nlm.nih.gov] On further investigations for bicytopenia, histoplasmosis had been diagnosed on bone marrow trephine biopsy.[ncbi.nlm.nih.gov]

  • Sepsis

    A 63-year-old woman presented with fever, tachycardia and tachypnoea, with right sided chest and hypochondrial pain.[ncbi.nlm.nih.gov] […] neonates is an uncommon condition that should be included in the differential diagnosis of infants displaying hemolytic anemia, thrombocytopenia, cholestatic jaundice, and hepatosplenomegaly[ncbi.nlm.nih.gov] DIAGNOSIS: The present patient met 5 of the HLH criteria: fever, splenomegaly, bicytopenia, hypertriglyceridemia and/or hypofibrinogenemia, and hyperferritinemia.[ncbi.nlm.nih.gov]

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