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57 Possible Causes for Bicytopenia, Hyperpigmentation

  • Gaucher Disease

    People with this disease do not produce enough of an enzyme called glucocerebrosidase, which breaks down glucocerebroside, a fatty substance found in cells. Without sufficient enzyme, the fatty substance builds up in some cells and enlarges them. These enlarged cells are called Gaucher cells. Over time, Gaucher cells[…][pfizer.com]

  • Vitamin B12 Deficiency

    Laboratory data revealed bicytopenia with macrocytic anemia and methylmalonic acid in the urine, consistent with vitamin B12 deficient anemia.[ncbi.nlm.nih.gov] Hyperpigmentation as the first presentation of Vitamin B12 deficiency is rare.[ncbi.nlm.nih.gov] Localized hyperpigmentation is less frequently described, affecting palms, soles, and flexural areas.[ncbi.nlm.nih.gov]

  • Dermatomyositis

    After corticosteroid and tacrolimus combination therapy was started, bicytopenia and elevated serum ferritin and transaminase emerged.[ncbi.nlm.nih.gov] Poikiloderma vasculare atrophicans refers to mottled hyperpigmentation and hypopigmentation of the skin with in-between telangiectases and areas of atrophy and is considered[ncbi.nlm.nih.gov] Poikiloderma, a discoloration of the skin resulting from the combination of dilated blood vessels, hyperpigmentation, hypopigmentation, and mild skin thinning.[hss.edu]

  • Severe Aplastic Anemia

    The patient developed hyperpigmentation of the face, neck and chest region, arms, shoulders and legs.[ncbi.nlm.nih.gov]

  • Pancytopenia

    […] of bicytopenia and pancytopenia.[ijpmonline.org] An interesting case of fever, pancytopenia and hyperpigmentation. Ann Trop Med Public Health [serial online] 2013 [cited 2019 Aug 5];6:586-8.[atmph.org] Other features which may be found on examination are short stature, structual abnormalities of limbs, eyes and ears, hyperpigmentation, café au lait spots, purpura or petechiae[info.isabelhealthcare.com]

  • Disseminated Intravascular Coagulation

    Cronkhite-Canada syndrome (CCS) is a rare non-inherited disease characterized by gastrointestinal polyposis, chronic diarrhea, ectodermal dysplasia, skin hyperpigmentation[ncbi.nlm.nih.gov]

  • Abdominal Radiation

    She presented with bicytopenia with trilineage dyspoiesis in the peripheral blood, bone marrow aspirate and biopsy.[physio-pedia.com] Therapy Early changes Erythema Pink coloration Mild edema Itching, burning, mild discomfort Dry desquamation Partial loss of epidermal basal cells Dryness, scaling, peeling Hyperpigmentation[aafp.org]

  • Drug-induced Bone Marrow Suppression

    Early forms of myelodysplastic syndrome initially can manifest as a single cytopenia or, more often, as a bicytopenia.[emedicine.medscape.com] Additionally, hyperpigmentation of the skin may be seen. Carboplatinum (Paraplatin): administration is via the intravenous route over 15 minutes or longer.[healthcommunities.com] Side-effects include severe febrile reactions (high fevers); skin reactions (increased coloration- hyperpigmentation) as well as skin inflammation and swelling and thickening[healthcommunities.com]

  • Chronic Myeloid Leukemia

    In contrast to patients with RA and only dyserythropoiesis, patients with multilineage dysplasia have bicytopenia or pancytopenia, a higher incidence of cytogenetic abnormalities[doi.org] Hyperpigmentation induced by imatinib is an adverse reaction rarely described in literature.[ncbi.nlm.nih.gov] On detailed evaluation, the patient was found to have imatinib-induced dental hyperpigmentation.[ncbi.nlm.nih.gov]

  • Heavy Chain Disease

    The patient had an autoimmune bicytopenia.[biochemia-medica.com] […] nerve damage), Organomegaly (large liver or spleen), Endocrinopathy (abnormal hormone-producing glands), M-protein (elevated proteins in blood), and Skin abnormalities (hyperpigmentation[cancer.ucsf.edu] In addition, the presence of an autoimmune bicytopenia and a Klinefelter syndrome complicated the clinical context of the patient.[hrcak.srce.hr]

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