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121 Possible Causes for Bicytopenia, Leukemia

  • Paroxysmal Nocturnal Hemoglobinuria

    The indications included pancytopenia (all three cell lines), bicytopenia (two cell lines), and unicytopenia (one cell line).[] […] chromosomal abnormalities involving chromosome bands 13q12 to 13q14 (13q12q14) are frequently found in various hematologic malignancies, including chronic lymphoblastic leukemia[] Evolutions to myelodysplastic syndrome or acute leukemia were similar in both cohorts. There was less evolution to aplastic anemia in the treatment group.[]

  • Systemic Mastocytosis

    Although the patient responded to the treatment, the relapse with splenomegaly and bicytopenia was observed after 10 months.[] Leukemia 2007; [Epub ahead of print] Google Scholar 12.[] Herein, we report a case of 14-year-old girl with SM associated with acute myeloid leukemia with maturation with t(8;21).[]

  • Hypersplenism

    Bone marrow examination in Egyptian patients with bicytopenia/pancytopenia Somaia Mohammed Mousa Comparative Clinical Pathology (2015) 5.[] A 45-year-old woman with previously diagnosed chronic type adult T-cell leukemia (ATL) presented with abdominal discomfort and red eruptions on her arms and legs.[] We report a case of Chronic lymphocytic leukemia (CLL) with associated hypersplenism, that was referred to us for partial splenic embolization (PSE) as the patient was not[]

  • Primary Myelofibrosis

    A 56-year-old male with chronic idiopathic myelofibrosis and cytogenetic finding of 20q- after a period of 10 months developed acute Philadelphia-positive lymphoblastic leukemia[] Patients with primary myelofibrosis may have pancytopenia or bicytopenia and in that respect mimic patients with oligoblastic leukemia (myelodysplasia [MDS]; see Chap. 88)[] The molecular pathogenesis underlying the primary myelofibrosis (PMF) progression to acute myeloid leukemia (AML) is still not well defined.[]

  • Mantle Cell Lymphoma

    A 64-year-old male initially presented with fatigue, splenomegaly, and bicytopenia. The bone marrow biopsy specimen revealed extensive infiltration with MCL.[] The concurrent presentation of mantle cell lymphoma with large granular lymphocytic leukemia simultaneously has never been reported.[] Morphology of peripheral blood and immunophenotyping by flow cytometry pointed to a diagnosis of chronic lymphocytic leukemia.[]

  • Promyelocytic Leukemia

    The patient was treated with all-trans retinoic acid under a diagnosis of APL with improvement of the bicytopenia.[] Promyelocytic leukemia (PL) is a hematopoietic malignancy and more specifically a type of acute myelogenous leukemia (AML), which is characterized by the increased levels[] 90% according to one study. [5] [4] [6] Contents Signs and symptoms Edit The symptoms tend to be similar to AML in general with the following being possible symptoms: [7] Bicytopenia[]

  • Refractory Anemia with Excess Blasts

    Diagnosis Comment: There is leukocytosis and bicytopenia (normocytic anemia and thrombocytopenia).[] Disease subsets consisted of patients with acute non-lymphocytic leukemia (ANLL) over age 60; ANLL refractory to standard therapy; smouldering leukemia; and refractory anemia[] Refractory cytopenia with multilineage dysplasia is characterized by bicytopenia or pancytopenia.[]

  • Penicillamine

    Cessation of D-Pen and the start of corticosteroid therapy were followed by recovery from bicytopenia.[] The H(2)O(2)-mediated cytotoxicity was greater in leukemia cells compared to breast cancer cells.[] D-pen alone was shown not to enter leukemia cells.[]

  • Chlamydophila Pneumoniae

    In this study, we explored the molecular mechanism involved in C. pneumoniae infection by using human acute T cell leukemia cell line, Jurkat E6-1.[] Laboratory work up revealed bicytopenia (white cell count 1.37 10(9)/L, platelets 60 10(9)/L) and an increase in C reactive protein (9 mg/dL).[]

  • Leprosy

    Leukemic skin infiltrations in patients with leukemia are referred to as leukemia cutis.[] While on antileprosy treatment, he developed unexplained persistent fever, organomegaly, bicytopenia, and elevated rate of inflammatory markers with bone marrow aspirate showing[] It can be seen in all types of leukemia, especially in patients with acute myelomonocytic leukemia (AML).[]

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