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50 Possible Causes for Bicytopenia, Leukocytes Increased

  • Sepsis

    DIAGNOSIS: The present patient met 5 of the HLH criteria: fever, splenomegaly, bicytopenia, hypertriglyceridemia and/or hypofibrinogenemia, and hyperferritinemia.[ncbi.nlm.nih.gov] […] into peripheral tissue, as well as specific alterations in cytokine patterns, with increased concentrations of the early proinflammatory cytokines, tumor necrosis factor-α[doi.org] Progression is associated with a significant increase in morbidity and mortality.[healthcare.siemens.com]

  • Disseminated Intravascular Coagulation

    J Card Surg. 2012 Nov;27(6):730-5. doi: 10.1111/jocs.12010. Abstract Disseminated intravascular coagulation (DIC) is a well-described complication of aortic aneurysm. In cases where surgical repair of the aneurysm is contraindicated, palliative therapy via medical management of the coagulopathy may be warranted. We[…][ncbi.nlm.nih.gov]

  • Leukemoid Reaction

    Infection induced hemophagocytic lymphohistiocytosis with a leukemoid reaction was suspected because of fever, splenomegaly and bicytopenia in conjunction with elevated serum[ncbi.nlm.nih.gov] Leukemoid Reaction (LR) is defined by reactive increase in leukocyte count of more than 50,000/cu mm with increase in mature leukocytes on peripheral blood.[jcdr.net] Unlike CML, leukocyte alkaline phosphatase is increased and the bcr/abl translocation is absent.[wakemedicine.wordpress.com]

  • Acute Leukemia

    A 43-year-old female presented with leukocytosis and bicytopenia.[ncbi.nlm.nih.gov] Leukocytes in about 50% of patients at the time of diagnosis was increased.[intechopen.com] Initial CBC showed bicytopenia, elevated blood urea, creatinine, and serum uric acid, while abdominal ultrasonography revealed bilateral renal enlargement.[ncbi.nlm.nih.gov]

  • Mantle Cell Lymphoma

    Further investigation revealed bicytopenia with splenomegaly and elevated serum creatinine.[ncbi.nlm.nih.gov] A 64-year-old male initially presented with fatigue, splenomegaly, and bicytopenia. The bone marrow biopsy specimen revealed extensive infiltration with MCL.[ncbi.nlm.nih.gov]

  • Primary Myelofibrosis

    Patients with primary myelofibrosis may have pancytopenia or bicytopenia and in that respect mimic patients with oligoblastic leukemia (myelodysplasia [MDS]; see Chap. 88)[patient-help.com] […] blood counts with immature granulocytes and atypical platelets Later cytopenias develop, more dysplastic cells, teardrop elliptocytes / dacrocytes Leukocyte (neutrophil)[pathologyoutlines.com] There may also be an increased number of leukocytes (white blood cells) and platelets and an enlarged spleen.[ajmc.com]

  • Autoimmune Hemolytic Anemia

    Autoimmune bicytopenia in pulmonary tuberculosis. Report of a pediatric case. Respir Med CME 2008;1:281-3. 9. Safe IP, O'brien C, Ferreira FR, Souza ML, Ramasawmy R.[jahjournal.org]

  • Acute Erythroblastic Leukemia

    The initial diagnoses were chronic myeloid leukemia in two, myelodysplastic syndrome in nine including four cases of Down syndrome, pancytopenia or bicytopenia in three, and[jstage.jst.go.jp] There may also be an increased number of granular leukocytes called eosinophils, a type of granulocyte that often has a two-lobed nucleus.[cancercenter.com] It is accompanied by a reduced number of erythrocytes and blood platelets, resulting in anemia and increased susceptibility to infection and hemorrhage.[medical-dictionary.thefreedictionary.com]

  • Gaucher Disease

    EEG examination revealed increased theta waves.[ncbi.nlm.nih.gov] However, the leukocyte β-glucosidase activity was in a normal range.[ncbi.nlm.nih.gov]

  • Hypereosinophilic Syndrome

    F/P HES): almost exclusively in males with FIP1L1-PDGFRA fusion (FIP1-like-1 fused with platelet-derived growth factor receptor α [F/P] and increased serum vitamin B 12, bicytopenia[unboundmedicine.com] […] blood, increased alkaline phosphatase level, chromosomal abnormalities, and reticulin fibrosis.[emedicine.medscape.com] In addition, some patients with hypereosinophilic syndrome present with features typical of MPDs, such as hepatosplenomegaly, the presence of leukocyte precursors in the peripheral[emedicine.medscape.com]

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