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28 Possible Causes for Bicytopenia, Liver Enzymes Abnormal, Pancytopenia

  • Severe Aplastic Anemia

    Abstract Severe aplastic anemia (SAA) is an autoimmune disease characterized by severe pancytopenia and bone marrow failure.[] This condition is termed pancytopenia.[] Abstract Human parvovirus B19 (PVB19) infection may cause mild pancytopenia characterized by transient and spontaneous recovery in healthy subjects.[]

  • Gaucher Disease

    This therapy can help reduce abnormalities in the bone, decrease liver and spleen size and reverse some abnormal blood counts.[] […] w/ severe thrombocytopenia is seen; - splenectomy offers temporary relief but pancytopenia may recur w/ depletion of the normal marrow elements; - Radiographs: - fusiform[] […] enzyme deficiency in Ashkenazi Jews Presentation Symptoms chronic fatigue Physical exam hepatosplenomegaly bony abnormalities - avascular necrosis anemia (and sometimes pancytopenia[]

  • Cladribine

    abnormalities.[] This disease is often found in middle-aged men with the typical manifestations of pancytopenia and splenomegaly.[] Although the patient responded to the treatment, the relapse with splenomegaly and bicytopenia was observed after 10 months.[]

  • Leukoerythroblastic Anemia

    Liver function tests may be abnormal in advanced disease. Liver biopsy to demonstrate reduced enzyme activity is the confirmatory test.[] Pancytopenia was seen in 9.55% (17) cases and bicytopenia in 50.5% (90) patients.[] Myeloproliferative Disease, Autosomal Recessive Myeloproliferative Disorder, Chronic, with Eosinophilia myeloproliferative neoplasm neonatal anemia normocytic anemia pancytopenia[]

  • Promyelocytic Leukemia

    Retinoids have been associated with side effects such as skin problems (dryness, peeling, itching, sun sensitivity), reversible elevation in liver enzymes, temporary abnormal[] The patient was treated with all-trans retinoic acid under a diagnosis of APL with improvement of the bicytopenia.[] We report a case of recurrent pancytopenia resulting from maintenance chemotherapy in a patient with acute promyelocytic leukemia and two pharmacogenetic mutations, namely[]

  • Systemic Mastocytosis

    Concurrently, abnormally elevated liver enzymes (especially alkaline phosphatase) were noted and further workup with magnetic resonance cholangio-pancreatography and liver[] Although the patient responded to the treatment, the relapse with splenomegaly and bicytopenia was observed after 10 months.[] The disease progressed rapidly and severe pancytopenia and recurrent upper gastrointestinal bleeding became the dominant problem.[]

  • Transient Infantile Hypertriglyceridemia and Hepatosteatosis

    enzymes only once majority of liver parenchyma is destroyed or major bile ducts are obstructed with tumor.[] 10%): Neutropenia Uncommon (0.1% to 1%): Anemia, neutrophil count decreased, thrombocytopenia , white blood cell count decreased Frequency not reported : Agranulocytosis, bicytopenia[] 21934233 [ABSTRACT] [HTML Full text] [PDF] [Mobile Full text] [EPub] [Citations (1) ] [PubMed] [Sword Plugin for Repository] Beta Parvovirus B19 presenting with persistent pancytopenia[]

  • Familial Hemophagocytic Lymphohistiocytosis

    The typical clinical characteristics of FHL are a prolonged fever that is accompanied by hepatomegaly, elevated liver enzymes, cytopenias, and less commonly, a rash and lymphadenopathy[] Hemogram revealed bicytopenia and bone marrow aspirate showed hemophagocytosis.[] Pancytopenia complicated by sepsis or bleeding, hepatic failure, or encephalopathy were the terminal events.[]

  • Macrophage Activation Syndrome

    Laboratory findings were: abnormal liver enzymes, increased triglyceride and ferritin levels, anemia .Hyperplasia of hemophagocytic macrophages was remarkable in her bone[] A 26-yearold woman with classical features of AOSD developed persistent fever, severe bicytopenia associated with extreme hyperferritinemia, hyponatremia and abnormal liver[] We report a case of Macrophage Activation Syndrome presenting as pyrexia of unknown origin (PUO) and pancytopenia in the absence of any known triggering factor.[]

  • Hepatosplenic T-cell Lymphoma

    enzyme abnormalities (46%), in the absence of lymphadenopathy[ 3 ].[] There was bicytopenia (hemoglobin - 101 g/L, platelet count - 38 10 9 /L, and total leukocyte count - 5 10 9 /L) with only a few blasts in peripheral blood film [Figure 1][] Patients presented with fatigue, hepatosplenomegaly, and pancytopenia.[]

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