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46 Possible Causes for Bicytopenia, Macrocytic Anemia

  • Severe Aplastic Anemia

    If cell size is much smaller than normal, it is known as microcytic anemia. If it is much bigger than normal, then it is macrocytic anemia.[labtestsonline.org] Diamond-Blackfan anemia Diamond-Blackfan anemia (DBA) is characterized by a normochromic macrocytic anemia that can be isolated, or it can be associated with growth retardation[emedicine.medscape.com] Dubowitz syndrome is also associated with eczema, immune deficiency, and aplastic anemia.[emedicine.medscape.com]

  • Vitamin B12 Deficiency

    Laboratory data revealed bicytopenia with macrocytic anemia and methylmalonic acid in the urine, consistent with vitamin B12 deficient anemia.[ncbi.nlm.nih.gov] Macrocytic anemias are generally classified into megaloblastic or nonmegaloblastic anemia.[doi.org] Megaloblastic anemias are a subgroup of macrocytic anemias, in which distinctive morphologic abnormalities occur in red cell precursors in bone marrow, namely megaloblastic[ncbi.nlm.nih.gov]

  • Paroxysmal Nocturnal Hemoglobinuria

    Progression from bicytopenia to pancytopenia or a new episode of bicytopenia or pancytopenia after recovery was not considered as a first progression to bicytopenia or pancytopenia[bloodjournal.hematologylibrary.org] CBC showed leukopenia (WBC 2.9 x 103 /µL) with neutropenia (segmented neutrophils 48%), macrocytic anemia (Hgb 6.1 g/dL, hematocrit 20%, MCV,113 fL) and thrombocytopenia ([ncbi.nlm.nih.gov] Alternative Names Macrocytic achylic anemia; Congenital pernicious anemia; Juvenile pernicious anemia; Vitamin B12 deficiency (malabsorption); Anemia - intrinsic factor; Anemia[mclaren.org]

  • Myelodysplasia

    2017) Age – median is 65-70 Sex – M F Classification Classification of MDS, Subtypes Subtype Blood Bone Marrow MDS cytopenias with single lineage dysplasia Unicytopenia or bicytopenia[arupconsult.com] Medical Importance The myelodysplastic syndromes are clonal hematopoietic disorders that commonly cause macrocytic anemia in older patients.[hematology.org] […] results of both blood tests and bone marrow biopsy results. 2016 WHO Classification of MDS Subtype Blood Bone Marrow MDS with single lineage dysplasia (MDS-SLD) Single of bicytopenia[oncolink.org]

  • Idiopathic Refractory Anemia

    My Response Distinguishing Cases of Immune-Mediated BM failure Diagnosing MDS is often challenging in patients with pancytopenia or bicytopenia who do not show definitive[hematology.org] Macrocytic anemia is usually caused by vitamin d eficiencies, alcohol use, medication s or thyroid.[seer.cancer.gov] The terms “ICUS-anemia, ICUS-neutropenia, ICUS-thrombocytopenia, ICUS-bicytopenia, or bi/pancytopenia” were also proposed in which the cut-off levels of cytopenia were the[intechopen.com]

  • Refractory Megaloblastic Anemia

    CLASSIFICATION OF MDS (2008) SUBTYPE BLOOD BONE MARROWREFRACTORY ANEMIA; UNILINEAGECYTOPENIA WITH NO OR RARE BLASTS DYSPLASIA 10%UNILINEAGE UNICYTOPENIA CELLS IN ONEDYSPLASIA (RCUD) BICYTOPENIA[slideshare.net] TOC HEME Approach to Macrocytic /Megaloblastic Anemia By means of morphologic and biochemical criteria, macrocytic anemias can be divided into two groups: The megaloblastic[enotes.tripod.com] Examples include causesof splenomegaly, indications for splenectomy, differential diagnosis of normocytic anemia,macrocytic anemia, hypochromic anemia, thrombocytopenia, bone[books.google.de]

  • Pancytopenia

    […] of bicytopenia and pancytopenia.[ijpmonline.org] The predominant blood picture was dimorphic anemia (37.5%), followed by macrocytic anemia (31.7%); peripheral smear showed macro-ovalocytes with hypersegmented neutrophils[jlponline.org] Elevated LDH and indirect bilirubin values, erythrocyte indexes compatible with macrocytic anemia and reticulocytopenia were abnormal in his first laboratory results.[omicsonline.org]

  • Primary Myelofibrosis

    Patients with primary myelofibrosis may have pancytopenia or bicytopenia and in that respect mimic patients with oligoblastic leukemia (myelodysplasia [MDS]; see Chap. 88)[patient-help.com]

  • Acute Erythroblastic Leukemia

    The initial diagnoses were chronic myeloid leukemia in two, myelodysplastic syndrome in nine including four cases of Down syndrome, pancytopenia or bicytopenia in three, and[jstage.jst.go.jp] : hypogranulation, hyposegmentation Megakaryocytes: small, non-lobulated cells Older patients Asymptomatic, or BM failure Macrocytic anemia Low-grade: support, follow.[quizlet.com] An excellent example was case 352 Image 1D , a 20-year-old man who had jaundice and severe macrocytic anemia.[academic.oup.com]

  • Leukoerythroblastic Anemia

    Pancytopenia was seen in 9.55% (17) cases and bicytopenia in 50.5% (90) patients.[jahjournal.org] Nephropathy 2 hemolytic anemia hypochromic anemia Leukemoid Reaction macrocytic anemia Malarial Anemia microcytic anemia multiple myeloma myelodysplastic/myeloproliferative[rgd.mcw.edu] Out of 70 cases 32 were reported as pancytopenia, 17 were microcytic hypochromic anemia, 10 normocytic normochromic blood picture, 3 dimorphic anemia ,2 bicytopenia, 2 CML[ispub.com]

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