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72 Possible Causes for Bicytopenia, Pallor

  • Gaucher Disease

    Summary Epidemiology The prevalence is approximately 1/100,000. The annual incidence of GD in the general population is about 1/60,000, but it can reach up to 1/1,000 in Ashkenazi Jewish populations. Clinical description The clinical manifestations of this disease are highly variable. GD type 1 (90% of cases) is the chronic[…][orpha.net]

  • Severe Aplastic Anemia

    There is usually a waxy pallor, and hemorrhages occur in the mucous membranes, skin, and other organs.[britannica.com] Physical findings : • Anemia with fatigue and pallor; • Bruising; • Petechiae (non-raised hemorrhage in the skin or in a membrane); • Bleeding gums; • Bleeding of internal[secure.ssa.gov] Low red cell count (anemia) can cause: Fatigue Pallor (paleness) Rapid heart rate Shortness of breath with exercise Weakness Lightheadedness upon standing Low white cell count[medlineplus.gov]

  • Sepsis

    DIAGNOSIS: The present patient met 5 of the HLH criteria: fever, splenomegaly, bicytopenia, hypertriglyceridemia and/or hypofibrinogenemia, and hyperferritinemia.[ncbi.nlm.nih.gov]

  • Disseminated Intravascular Coagulation

    In light of developing fluctuant subgaleal fluid associated with pallor, anemia, metabolic acidosis, and respiratory distress, immediate blood transfusion is warranted.[ncbi.nlm.nih.gov]

  • Paroxysmal Nocturnal Hemoglobinuria

    Progression from bicytopenia to pancytopenia or a new episode of bicytopenia or pancytopenia after recovery was not considered as a first progression to bicytopenia or pancytopenia[bloodjournal.hematologylibrary.org] Other features include weakness, abdominal and lumbar pain, jaundice with pallor and yellowish discoloration of the skin and mucous membranes, heart murmurs, splenomegaly,[whonamedit.com] […] disorder with insidious onset (usually in the third or fourth decade) and chronic course, characterized by episodes of hemolytic anemia, hemoglobinuria (chiefly at night), pallor[medical-dictionary.thefreedictionary.com]

  • Myelodysplasia

    2017) Age – median is 65-70 Sex – M F Classification Classification of MDS, Subtypes Subtype Blood Bone Marrow MDS cytopenias with single lineage dysplasia Unicytopenia or bicytopenia[arupconsult.com] Symptoms are referable to the specific cell line most affected and may include fatigue, weakness, pallor (secondary to anemia), increased infections and fever (secondary to[msdmanuals.com] […] results of both blood tests and bone marrow biopsy results. 2016 WHO Classification of MDS Subtype Blood Bone Marrow MDS with single lineage dysplasia (MDS-SLD) Single of bicytopenia[oncolink.org]

  • Acute Leukemia

    A 43-year-old female presented with leukocytosis and bicytopenia.[ncbi.nlm.nih.gov] The first case is a 4-year-old girl who presented with pallor and abdominal enlargement.[ncbi.nlm.nih.gov] The initial manifestations of leukemia are generally signs of bone marrow failure, such as pallor, fatigue, fever, bleeding, and infection related to peripheral blood cytopenias[ncbi.nlm.nih.gov]

  • Primary Myelofibrosis

    Patients with primary myelofibrosis may have pancytopenia or bicytopenia and in that respect mimic patients with oligoblastic leukemia (myelodysplasia [MDS]; see Chap. 88)[patient-help.com] Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy[orpha.net] Skin pallor (caused by anemia) may also be noticeable.[aoporphan.com]

  • Autoimmune Hemolytic Anemia

    Autoimmune bicytopenia in pulmonary tuberculosis. Report of a pediatric case. Respir Med CME 2008;1:281-3. 9. Safe IP, O'brien C, Ferreira FR, Souza ML, Ramasawmy R.[jahjournal.org] A 7-month-old boy, presented with prolonged fever, erythematous rash, severe pallor and hepatosplenomegaly.[ncbi.nlm.nih.gov] An otherwise seemingly normal girl, who had developed limping at the age of 11 months old, referred to Namazi Hospital, Shiraz, Iran, due to pallor and latitude at the age[ncbi.nlm.nih.gov]

  • Promyelocytic Leukemia

    The patient was treated with all-trans retinoic acid under a diagnosis of APL with improvement of the bicytopenia.[ncbi.nlm.nih.gov] Fatigue, weakness, pallor, weight loss, dyspnea, and fever are the initial, nonspecific symptoms that patients usually present with.[symptoma.com] The low number of red blood cells (anemia) can cause people with acute promyelocytic leukemia to have pale skin (pallor) or excessive tiredness (fatigue).[ghr.nlm.nih.gov]

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