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108 Possible Causes for Bicytopenia, Pancytopenia

  • Hypersplenism

    Pancytopenia can be limited by reducing the volume of the functional spleen.[] Bone marrow examination in Egyptian patients with bicytopenia/pancytopenia Somaia Mohammed Mousa Comparative Clinical Pathology (2015) 5.[] He was initially asymptomatic though there was mild pancytopenia.[]

  • Paroxysmal Nocturnal Hemoglobinuria

    The indications included pancytopenia (all three cell lines), bicytopenia (two cell lines), and unicytopenia (one cell line).[] We report a 19-year-old female patient admitted to the hospital with pancytopenia. Workout of pancytopenia disclosed paroxysmal nocturnal hemoglobinuria.[] The major causes of associated morbidity and mortality are chronic intravascular hemolysis, pancytopenia, and venous thrombosis.[]

  • Mantle Cell Lymphoma

    Splenomegaly is often massive, while aberrant WBC count may be seen, either as markedly high leukocytosis or pancytopenia.[] A 64-year-old male initially presented with fatigue, splenomegaly, and bicytopenia. The bone marrow biopsy specimen revealed extensive infiltration with MCL.[] Laboratory workup must include evaluation of all blood lineages, and either pancytopenia or marked leukocytosis may be observed.[]

  • Promyelocytic Leukemia

    We report a case of recurrent pancytopenia resulting from maintenance chemotherapy in a patient with acute promyelocytic leukemia and two pharmacogenetic mutations, namely[] The patient was treated with all-trans retinoic acid under a diagnosis of APL with improvement of the bicytopenia.[] Routine blood work showed pancytopenia and evidence of diffuse intravascular coagulation. A bone marrow biopsy confirmed the diagnosis of acute promyelocytic leukemia.[]

  • Severe Aplastic Anemia

    Severe aplastic anemia (SAA) is an autoimmune disease characterized by severe pancytopenia and bone marrow failure.[] Severe aplastic anemia is a disorder of stem cell failure, leading to pancytopenia.[] Human parvovirus B19 (PVB19) infection may cause mild pancytopenia characterized by transient and spontaneous recovery in healthy subjects.[]

  • Systemic Mastocytosis

    Although the patient responded to the treatment, the relapse with splenomegaly and bicytopenia was observed after 10 months.[] The disease progressed rapidly and severe pancytopenia and recurrent upper gastrointestinal bleeding became the dominant problem.[] […] organomegaly and organ dysfunction, impairment of hematopoietic function (which may result in disruption of the blood count ranging from isolated cytopenia to more or less marked pancytopenia[]

  • Disseminated Tuberculosis

    Patients and Methods 312 bone marrow aspirates from patients with the diagnosis of anaemia, severe granulocytopenia, thrombocytopenia, bicytopenia or pancytopenia, referred[] The purpose of this paper is to record a case of pancytopenia due to disseminated tuberculosis, and again to draw attention to the difficulties encountered in diagnosis.[] Working impression was bicytopenia, multi factorial, secondary to chronic inflammation, rule out tuberculous infiltration of the marrow.[]

  • Acute Leukemia

    A 43-year-old female presented with leukocytosis and bicytopenia.[] Pancytopenia in her secondary MF phase responded well to the therapy of corticosteroids, which indicated that the immune mechanism was involved in the pathogenesis of MF.[] Initial CBC showed bicytopenia, elevated blood urea, creatinine, and serum uric acid, while abdominal ultrasonography revealed bilateral renal enlargement.[]

  • Brucellosis

    The diagnostic criteria include fever, hepatosplenomegaly, bicytopenia, high serum ferritin level, decreased natural killer cell activity, elevated soluble CD25 level, high[] Pancytopenia improved with treatment of brucellosis on all patients.[] A 70-year-old woman presented with pancytopenia and fever of unknown origin (FUO).[]

  • Cladribine

    Although the patient responded to the treatment, the relapse with splenomegaly and bicytopenia was observed after 10 months.[] The laboratory findings that came into prominence were pancytopenia with grade 3 bone marrow fibrosis.[] Here we reported a 48-year-old men who was found to have splenomegaly and bicytopenia incidentally at routine physical checkup.[]

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