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108 Possible Causes for Bicytopenia, Pancytopenia

  • Hypersplenism

    Pancytopenia can be limited by reducing the volume of the functional spleen.[ncbi.nlm.nih.gov] Bone marrow examination in Egyptian patients with bicytopenia/pancytopenia Somaia Mohammed Mousa Comparative Clinical Pathology (2015) 5.[nature.com] He was initially asymptomatic though there was mild pancytopenia.[ncbi.nlm.nih.gov]

  • Paroxysmal Nocturnal Hemoglobinuria

    The indications included pancytopenia (all three cell lines), bicytopenia (two cell lines), and unicytopenia (one cell line).[bcmj.org] We report a 19-year-old female patient admitted to the hospital with pancytopenia. Workout of pancytopenia disclosed paroxysmal nocturnal hemoglobinuria.[ncbi.nlm.nih.gov] The major causes of associated morbidity and mortality are chronic intravascular hemolysis, pancytopenia, and venous thrombosis.[ncbi.nlm.nih.gov]

  • Mantle Cell Lymphoma

    Splenomegaly is often massive, while aberrant WBC count may be seen, either as markedly high leukocytosis or pancytopenia.[symptoma.com] A 64-year-old male initially presented with fatigue, splenomegaly, and bicytopenia. The bone marrow biopsy specimen revealed extensive infiltration with MCL.[ncbi.nlm.nih.gov] Laboratory workup must include evaluation of all blood lineages, and either pancytopenia or marked leukocytosis may be observed.[symptoma.com]

  • Promyelocytic Leukemia

    We report a case of recurrent pancytopenia resulting from maintenance chemotherapy in a patient with acute promyelocytic leukemia and two pharmacogenetic mutations, namely[ncbi.nlm.nih.gov] The patient was treated with all-trans retinoic acid under a diagnosis of APL with improvement of the bicytopenia.[ncbi.nlm.nih.gov] Routine blood work showed pancytopenia and evidence of diffuse intravascular coagulation. A bone marrow biopsy confirmed the diagnosis of acute promyelocytic leukemia.[ncbi.nlm.nih.gov]

  • Severe Aplastic Anemia

    Severe aplastic anemia (SAA) is an autoimmune disease characterized by severe pancytopenia and bone marrow failure.[ncbi.nlm.nih.gov] Severe aplastic anemia is a disorder of stem cell failure, leading to pancytopenia.[ncbi.nlm.nih.gov] Human parvovirus B19 (PVB19) infection may cause mild pancytopenia characterized by transient and spontaneous recovery in healthy subjects.[ncbi.nlm.nih.gov]

  • Systemic Mastocytosis

    Although the patient responded to the treatment, the relapse with splenomegaly and bicytopenia was observed after 10 months.[ncbi.nlm.nih.gov] The disease progressed rapidly and severe pancytopenia and recurrent upper gastrointestinal bleeding became the dominant problem.[ncbi.nlm.nih.gov] […] organomegaly and organ dysfunction, impairment of hematopoietic function (which may result in disruption of the blood count ranging from isolated cytopenia to more or less marked pancytopenia[orpha.net]

  • Disseminated Tuberculosis

    Patients and Methods 312 bone marrow aspirates from patients with the diagnosis of anaemia, severe granulocytopenia, thrombocytopenia, bicytopenia or pancytopenia, referred[tbonline.info] The purpose of this paper is to record a case of pancytopenia due to disseminated tuberculosis, and again to draw attention to the difficulties encountered in diagnosis.[annals.org] Working impression was bicytopenia, multi factorial, secondary to chronic inflammation, rule out tuberculous infiltration of the marrow.[medcraveonline.com]

  • Acute Leukemia

    A 43-year-old female presented with leukocytosis and bicytopenia.[ncbi.nlm.nih.gov] Pancytopenia in her secondary MF phase responded well to the therapy of corticosteroids, which indicated that the immune mechanism was involved in the pathogenesis of MF.[ncbi.nlm.nih.gov] Initial CBC showed bicytopenia, elevated blood urea, creatinine, and serum uric acid, while abdominal ultrasonography revealed bilateral renal enlargement.[ncbi.nlm.nih.gov]

  • Brucellosis

    The diagnostic criteria include fever, hepatosplenomegaly, bicytopenia, high serum ferritin level, decreased natural killer cell activity, elevated soluble CD25 level, high[ncbi.nlm.nih.gov] Pancytopenia improved with treatment of brucellosis on all patients.[ncbi.nlm.nih.gov] A 70-year-old woman presented with pancytopenia and fever of unknown origin (FUO).[ncbi.nlm.nih.gov]

  • Cladribine

    Although the patient responded to the treatment, the relapse with splenomegaly and bicytopenia was observed after 10 months.[ncbi.nlm.nih.gov] The laboratory findings that came into prominence were pancytopenia with grade 3 bone marrow fibrosis.[ncbi.nlm.nih.gov] Here we reported a 48-year-old men who was found to have splenomegaly and bicytopenia incidentally at routine physical checkup.[ncbi.nlm.nih.gov]

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