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15 Possible Causes for Bicytopenia, Pathological Fracture

  • Gaucher Disease

    fractures, and pyogenic osteomyelitis.[] But in adults, there are no reports of pathological femoral neck fractures with GD.[] BMD was low in 11 patients (50%); neither BMD nor HSA were associated with pathological fractures.[]

  • Bone Lymphoma

    We report a unique case of PBNHL with bicytopenia as the initial clinical manifestation in a Chinese.[] The treatment was designed to maintain efficacy but limit the risk of subsequent pathological fractures.[] Disease may be complicated at presentation by pathological fracture or spinal cord compression.[]

  • Paraneoplastic Syndrome

    A 40-year-old male with a history of peripheral neuropathy and erectile dysfunction presented with a pathological fracture of the neck of the femur, found to be a solitary[] More on polymyalgia rheumatica (PMR) as a paraneoplastic rheumatic syndrome in the elderly (bicytopenia and PMR preceding acute myeloid leukemia).[]

  • Evan's Syndrome

    The pattern of occurrence of bicytopenia can delay the diagnosis since it may be coincidental, sequential, or separate, and the time frame between episodes can range from[] Discussion The most common complications of multiple myeloma include anemia, hypercalcemia, pathologic fractures, renal failure and recurrent infections.[]

  • Leukoerythroblastic Anemia

    However, pain and tenderness of affected bones, pathologic fractures, and hypercalcemia causing nausea, symptoms of anemia, muscle weakness, or stupor may bring patients to[] Pancytopenia was seen in 9.55% (17) cases and bicytopenia in 50.5% (90) patients.[] Pathologic fractures of the bone and alterations of the bony cortex can indicate marrow expansion, in patients with thalassemia, some forms of leukemia and some myeloproliferative[]

  • Systemic Mastocytosis

    Rafii M, Firooznia H, Golimbu C, et al: Pathologic fracture in systemic mastocytosis. Clin Orthop 1983; 180:260-267. 6.[] Although the patient responded to the treatment, the relapse with splenomegaly and bicytopenia was observed after 10 months.[] In some patients, there is generalised osteoporosis with the risk of pathological fractures.[]

  • Acute Leukemia

    fracture Joint pain (must distinguish from arthritis and similar inflammatory conditions) Laboratory Usually elevated total leukocyte count, but could be normal or even reduced[] A 43-year-old female presented with leukocytosis and bicytopenia.[] Initial CBC showed bicytopenia, elevated blood urea, creatinine, and serum uric acid, while abdominal ultrasonography revealed bilateral renal enlargement.[]

  • Leukemoid Reaction

    Moreover, bone fracture of the joint socket was highly suspected. Magnetic resonance tomography (MRT) of her pelvis confirmed the pathological fracture.[] Infection induced hemophagocytic lymphohistiocytosis with a leukemoid reaction was suspected because of fever, splenomegaly and bicytopenia in conjunction with elevated serum[]

  • Bullous Pemphigoid

    For patients on azathioprine, two developed transaminitis and one had bicytopenia.[] […] and vertebral fractures, bone infarcts, and avascular necrosis leading to degenerative arthropathy).[] (GD1) is characterized by thrombocytopenia, anemia, an enlarged spleen, and liver as well as bone complications (Erlenmeyer flask deformity, osteoporosis, lytic lesions, pathological[]

  • Paraneoplastic Polyneuropathy

    More on polymyalgia rheumatica (PMR) as a paraneoplastic rheumatic syndrome in the elderly (bicytopenia and PMR preceding acute myeloid leukemia).[] Radiographic examination of limbs may show loss of bone density, thinning of phalanges, pathologic fractures or neuropathic arthropathy.[]

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