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80 Possible Causes for Bicytopenia, Splenomegaly

  • Gaucher Disease

    CONCLUSION: HALS for GD patients with refractory hypersplenism and massive splenomegaly is safe and feasible in experienced hands.[ncbi.nlm.nih.gov] After 4years of ERT, therapeutic goals for thrombocytopenia and splenomegaly had been achieved in 100% of patients; goals for anemia and hepatomegaly had been achieved in[ncbi.nlm.nih.gov] In symptomatic patients, splenomegaly is progressive and can become massive.[emedicine.medscape.com]

  • Disseminated Histoplasmosis

    On further investigations for bicytopenia, histoplasmosis had been diagnosed on bone marrow trephine biopsy.[ncbi.nlm.nih.gov] This case highlights consideration of disseminated histoplasmosis in patients presenting with diffuse adenopathy along with hepatomegaly and/or splenomegaly in the right clinical[ncbi.nlm.nih.gov] On the basis of a comparative analysis of those who died and survived, the absence of splenomegaly and hepatomegaly and the presence of H. capsulatum in the peripheral blood[ncbi.nlm.nih.gov]

  • Familial Hemophagocytic Lymphohistiocytosis

    BACKGROUND: Familial hemophagocytic lymphohistiocytosis (FHLH) is an autosomal recessively inherited multisystem disease characterized by fever, rash, splenomegaly, cytopenias[ncbi.nlm.nih.gov] Hemogram revealed bicytopenia and bone marrow aspirate showed hemophagocytosis.[link.springer.com] […] guidelines of the Histiocyte Society, diagnosis of Hemophagocytic Lympho-histiocytosis (HLH) requires fulfillment of 5 out of 8 criteria – prolonged fever, splenomegaly, bicytopenia[indianpediatrics.net]

  • Extramedullary Hematopoiesis

    METHODS: A 58-year-old woman underwent workup for bicytopenia, and was diagnosed with MM based on the results of bone marrow aspiration and serum protein electrophoresis.[ncbi.nlm.nih.gov] These findings thus challenge our understanding of splenomegaly as a marker of disease. Copyright 2011 Wiley Periodicals, Inc.[ncbi.nlm.nih.gov] Medullary expansion of the bony structures with widening of the ribs being the most pronounced bony finding Resorption of trabeculae produces coarsened appearance to bones Splenomegaly[learningradiology.com]

  • Hepatosplenic Lymphoma

    There was bicytopenia (hemoglobin - 101 g/L, platelet count - 38 10 9 /L, and total leukocyte count - 5 10 9 /L) with only a few blasts in peripheral blood film [Figure 1][ijpmonline.org] Splenectomy was performed due to progressive splenomegaly.[adc.bmj.com] It occurs mainly in young adults presenting with splenomegaly and most often with hepatomegaly but without lymphadenopathy.[bloodjournal.org]

  • Acute Leukemia

    Symptoms include splenomegaly, monocytosis with granulocytosis, and thrombocytopenia. leukemia cu tis leukemia with leukocytic invasion of the skin marked by pink, reddish[medical-dictionary.thefreedictionary.com] A 43-year-old female presented with leukocytosis and bicytopenia.[ncbi.nlm.nih.gov] Initial CBC showed bicytopenia, elevated blood urea, creatinine, and serum uric acid, while abdominal ultrasonography revealed bilateral renal enlargement.[ncbi.nlm.nih.gov]

  • Hypersplenism

    RESULTS: While 38 patients displayed splenomegaly, 121 showed normal spleen volumes at 6 months after LDLT (LDLT).[ncbi.nlm.nih.gov] Baijal & Anshu Srivastava Hepatology International (2015) Bone marrow examination in Egyptian patients with bicytopenia/pancytopenia Somaia Mohammed Mousa Comparative Clinical[nature.com] Introduction Splenomegaly and hypersplenism can develop in association with hemolytic anemia.[nethealthbook.com]

  • Paroxysmal Nocturnal Hemoglobinuria

    Progression from bicytopenia to pancytopenia or a new episode of bicytopenia or pancytopenia after recovery was not considered as a first progression to bicytopenia or pancytopenia[bloodjournal.hematologylibrary.org] BACKGROUND: PNH is associated with abdominal vein thrombosis, which can cause splenomegaly and hypersplenism.[ncbi.nlm.nih.gov] We describe a patient under treatment with the anti-complement antibody eculizumab who developed pancytopenia, requiring blood transfusions, due to massive splenomegaly.[ncbi.nlm.nih.gov]

  • Systemic Mastocytosis

    Although the patient responded to the treatment, the relapse with splenomegaly and bicytopenia was observed after 10 months.[ncbi.nlm.nih.gov] We present the case of a 41-year-old woman with thrombocytosis and mild splenomegaly. Clinical suspicion was of chronic myeloproliferative neoplasia (CMN).[ncbi.nlm.nih.gov] […] without hypersplenism, and/or palpable visceral lymphadenopathy Palpable hepatomegaly with impairment of liver function, ascites, or portal hypertension Palpable splenomegaly[bloodref.com]

  • Castleman Disease

    Older age ( 40 years), splenomegaly, and hypoalbuminemia were risk factors for poorer MCD prognosis. 2017 The Authors.[ncbi.nlm.nih.gov] Investigations showed bicytopenia, nephrotic range proteinuria with hypoalbuminemia, hypogammaglobulinemia, and features of hyaline-vascular type Castleman disease in a lymph[ncbi.nlm.nih.gov] The disease is characterized by fever, weight loss, anemia, polyclonal hyperglobulinemia, splenomegaly, thrombocytosis and peripheral lymphadenopathy.[ncbi.nlm.nih.gov]

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