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105 Possible Causes for Bicytopenia, Splenomegaly

  • Hypersplenism

    While 38 patients displayed splenomegaly, 121 showed normal spleen volumes at 6 months after LDLT (LDLT).[ncbi.nlm.nih.gov] Bone marrow examination in Egyptian patients with bicytopenia/pancytopenia Somaia Mohammed Mousa Comparative Clinical Pathology (2015) 5.[nature.com] Introduction Splenomegaly and hypersplenism can develop in association with hemolytic anemia.[nethealthbook.com]

  • Gaucher Disease

    HALS for GD patients with refractory hypersplenism and massive splenomegaly is safe and feasible in experienced hands.[ncbi.nlm.nih.gov] After 4years of ERT, therapeutic goals for thrombocytopenia and splenomegaly had been achieved in 100% of patients; goals for anemia and hepatomegaly had been achieved in[ncbi.nlm.nih.gov] In symptomatic patients, splenomegaly is progressive and can become massive.[emedicine.medscape.com]

  • Malaria

    The prevalence of cytopenias were; 29.6, 48.0% for anemia, 38.9, 12.0% for thrombocytopenia, 20.4, 12.0% for leukopenia, 13.0, 8.0% for bicytopenia and 5.6, 4.0% for pancytopenia[ncbi.nlm.nih.gov] We report the case of a 12-year-old child who was admitted to our Department, with 7 days' history of high fever and splenomegaly.[ncbi.nlm.nih.gov] Hyperreactive malarial splenomegaly (also called “tropical splenomegaly syndrome”) occurs infrequently and is attributed to an abnormal immune response to repeated malarial[cdc.gov]

  • Autoimmune Hemolytic Anemia

    Examination demonstrated scleral icterus, splenomegaly, and anemia. By peripheral blood smear, the patient was diagnosed with Plasmodium ovale.[ncbi.nlm.nih.gov] Autoimmune bicytopenia in pulmonary tuberculosis. Report of a pediatric case. Respir Med CME 2008;1:281-3. 9. Safe IP, O'brien C, Ferreira FR, Souza ML, Ramasawmy R.[jahjournal.org] She was found to have splenomegaly, generalized lymphadenopathy, pancytopenia, and acute hepatic failure.[ncbi.nlm.nih.gov]

  • Brucellosis

    The diagnostic criteria include fever, hepatosplenomegaly, bicytopenia, high serum ferritin level, decreased natural killer cell activity, elevated soluble CD25 level, high[ncbi.nlm.nih.gov] The most frequent admission symptoms and findings of the patients with pancytopenia were fever (75%), fatigue (50%), splenomegaly (75%), and hepatomegaly (41%).[ncbi.nlm.nih.gov] Tender hepatomegaly or splenomegaly was striking in seven patients. Other characteristics included epistaxis, arthralgia, myalgia, and weight loss.[pediatrics.aappublications.org]

  • Mantle Cell Lymphoma

    Fatigue, generalized lymphadenopathy and splenomegaly are its typical features.[symptoma.com] A 64-year-old male initially presented with fatigue, splenomegaly, and bicytopenia. The bone marrow biopsy specimen revealed extensive infiltration with MCL.[ncbi.nlm.nih.gov] A baseline F-FDG PET/CT scan in a patient with mantle cell lymphoma showed diffuse minimally FDG-avid lymphadenopathy and splenomegaly.[ncbi.nlm.nih.gov]

  • Extramedullary Hematopoiesis

    These findings thus challenge our understanding of splenomegaly as a marker of disease.[ncbi.nlm.nih.gov] A 58-year-old woman underwent workup for bicytopenia, and was diagnosed with MM based on the results of bone marrow aspiration and serum protein electrophoresis.[ncbi.nlm.nih.gov] Medullary expansion of the bony structures with widening of the ribs being the most pronounced bony finding Resorption of trabeculae produces coarsened appearance to bones Splenomegaly[learningradiology.com]

  • Disseminated Histoplasmosis

    This case highlights consideration of disseminated histoplasmosis in patients presenting with diffuse adenopathy along with hepatomegaly and/or splenomegaly in the right clinical[ncbi.nlm.nih.gov] On further investigations for bicytopenia, histoplasmosis had been diagnosed on bone marrow trephine biopsy.[ncbi.nlm.nih.gov] On the basis of a comparative analysis of those who died and survived, the absence of splenomegaly and hepatomegaly and the presence of H. capsulatum in the peripheral blood[ncbi.nlm.nih.gov]

  • Hypertriglyceridemia

    The potential etiologies of splenomegaly vary with the patient’s age.[clinchem.aaccjnls.org] […] hypoproteinemic edema who also had extreme hypertriglyceridemia (21 mmol/l) and was diagnosed with HLH based on six of eight HLH-2004 criteria (fever, hepatosplenomegaly, bicytopenia[ncbi.nlm.nih.gov] There was no family history of consanguinity, splenomegaly, diabetes, or developmental delay.[clinchem.aaccjnls.org]

  • Autoimmune Lymphoproliferative Syndrome

    […] hepatitis, vasculitis, arthritis and central nervous system involvement (seizures, headache, encephalopathy). [5] Our patient had nonmalignant enlargement of lymph nodes, and bicytopenia[ijpd.in] We conclude that in selected patients with marked splenomegaly and ALPS, splenectomy may be considered a treatment option.[ncbi.nlm.nih.gov] […] the male Pt. 1 presented with failure to thrive, mild fever, extensive splenomegaly (12 cm in length, as assessed with ultrasound imaging), generalized lymphadenopathy, bicytopenia[bloodadvances.org]

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