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32 Possible Causes for Bicytopenia, Sudden Death

  • Brugada Syndrome

    Laboratory work up revealed bicytopenia (white cell count 1.37 10(9)/L, platelets 60 10(9)/L) and an increase in C reactive protein (9 mg/dL).[] This is known as sudden arrhythmic death syndrome, or SADS.[] Antiarrhythmic drugs like amiodarone and beta-blockers do not prevent sudden death in symptomatic or asymptomatic individuals.[]

  • Disseminated Intravascular Coagulation

    Hemorrhage into the central nervous system may cause acute onset of neurological dysfunction or sudden death.[]

  • Gaucher Disease

    Sudden unexpected death and unusual behavior may occur in Gaucher type 3, particularly in Egyptian patients.[]

  • Hypereosinophilic Syndrome

    F/P HES): almost exclusively in males with FIP1L1-PDGFRA fusion (FIP1-like-1 fused with platelet-derived growth factor receptor α [F/P] and increased serum vitamin B 12, bicytopenia[]

  • Severe Aplastic Anemia

    The cause of death was found only after autopsy.[] A 10-year-old patient with severe aplastic anemia underwent matched sibling donor hematopoietic stem cell transplantation, but developed sudden onset of fatal multiorgan failure[]

  • Adenovirus Infection

    […] encephalopathy, myocarditis, rash) was diagnosed with adenovirus-associated macrophage activation syndrome according to clinical and laboratory parameters (fever, hepatosplenomegaly, bicytopenia[] […] infant perinatal death [ 32 ], and, perhaps most intriguingly, the development of obesity [ 33, 34 ].[] […] chronic airway obstruction [ 27 ] and pulmonary dysplasia [ 28 ], myocarditis and dilated cardiomyopathy [ 29 ], mononucleosis-like syndromes [ 30 ], intussusception [ 31 ], sudden[]

  • Acquired Angioedema

    In view of bicytopenia with lymphopenia, ANA positive and hypocomplementemia, diagnosis of systemic lupus erythematosus was suspected.[] Angiotensin II receptor blockers (ARBs) Hereditary angioedema : look for a younger patient with a family history of angioedema or of sudden death at an early age from unexplained[] Laboratory investigation showed bicytopenia with hemoglobin of 11.4 g/dL (normal range 10.7–14.9), a white blood cell count of 2.88x10 3 /µL (normal range 3.30x10 3 –9.66x10[]

  • Paraneoplastic Syndrome

    More on polymyalgia rheumatica (PMR) as a paraneoplastic rheumatic syndrome in the elderly (bicytopenia and PMR preceding acute myeloid leukemia).[] […] asymmetric hearing loss, found to have a 12-cm renal mass before death, and a third with fluctuating bilateral hearing loss who was ultimately found to have a thymoma.[] […] history of B-cell follicular lymphoma who developed dermatomyositis and hearing loss before detection of lymphoma recurrence in his anterior chest wall, a second patient with sudden[]

  • Agranulocytosis

    Since there was a possibility of autoimmune etiology for bicytopenia, rheumatology opinion was sought following which CANCA (cytoplasm antineutrophil cytoplasmic antibodies[] death Agranulocytosis may have a genetic basis.[] […] bone marrow whereas thiouracil, sulfonamides and aminopyrine trigger an antibody mediated destruction of mature neutrophils. [1,2,3,4,5] Family history of infections or sudden[]

  • Leukoerythroblastic Anemia

    Pancytopenia was seen in 9.55% (17) cases and bicytopenia in 50.5% (90) patients.[] In the early years of sickle-cell anaemia, sudden pooling of red cells in the spleen may develop, causing a rapid fall in haemoglobin concentration, which can lead to death[] Pancytopenia was seen in 9.55% (17) cases and bicytopenia in 50.5% (90) patients. Only eight cases had bone marrow correlation.[]

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