Possible Causes for Bilateral Arm Weakness, Cardiomyopathy & Cervico-Occipital Neuralgia Duchenne Muscular Dystrophy She was treated for peripartum cardiomyopathy (PPCM) with angiotensin converting enzyme inhibitors (ACEi), beta-blockers and diuretics with normalisation of her cardiac function [ncbi.nlm.nih.gov] We present the case of a 29-year-old man with mutation-positive Duchenne muscular dystrophy and mutation-positive hypertrophic cardiomyopathy. [ncbi.nlm.nih.gov] BACKGROUND: Duchenne muscular dystrophy (DMD) is frequently complicated by development of a cardiomyopathy. [ncbi.nlm.nih.gov] Pompe Disease The infantile form is fatal in infancy and presents with hypotonia and a hypertrophic cardiomyopathy (cardiomyopathy, hypertrophic). [icd10data.com] lysosomal disease with hypertrophic cardiomyopathy, glycogen storage disease with hypertrophic cardiomyopathy, lysosomal glycogen storage disease Prende il nome da Johannes [commons.wikimedia.org] In the classic infantile form (Pompe disease), cardiomyopathy and muscular hypotonia are the cardinal features. [humpath.com] Hereditary ATTR Amyloidosis Screening for transthyretin amyloid cardiomyopathy in everyday practice. [academic.oup.com] cardiomyopathy. [healthcare-bulletin.com] Introduction Amyloid cardiomyopathy is frequently encountered in patients with transthyretin (ATTR) amyloidosis. [journals.plos.org] Erb Muscular Dystrophy […] insufficiency MedLine Citation: PMID: 6706057 Owner: NLM Status: MEDLINE Abstract/OtherAbstract: We describe a case of Erb's limb girdle muscular dystrophy with congestive cardiomyopathy [biomedsearch.com] cardiomyopathy 7, 2 Nemaline myopathy 4, 5 Tropomyosin Hypertrophic cardiomyopathy 3 Nemaline myopathy 1 Titin Hypertrophic cardiomyopathy 9 Other Fibrillin Marfan syndrome [en.wikipedia.org] 5 General features Nosology: X-linked Dilated Cardiomyopathy Onset: Commonly in teenage years Types: Dilated cardiomyopathy > Hypertrophic > Conduction defects Possible biomarker [neuromuscular.wustl.edu] Platybasia Abstract Descriptions of the flattening (platybasia) of the skull base and the upward displacement(impression) of the basilar and condylar portions of the occipitalbone by the upper cervical spine date to the late 18th and early 19th centuries. Anatomical measurements to display these abnormalities were begun in[…] [doi.org] MERRF Syndrome bilateral cataract surgery at age 39, and showed progressive loss of balance and arm weakness at age 47. [ncbi.nlm.nih.gov] Patients usually present in late adolescence or early adulthood with 1-3 myoclonus epilepsy cerebellar ataxia intellectual disability vision and/or hearing loss cardiomyopathy [radiopaedia.org] Most patients have signs of cardiomyopathy and dysrhythmia, usually Wolff-Parkinson-White Syndrome. [accessanesthesiology.mhmedical.com] Cocaine Abuse arm weakness. [cdc.gov] The clinical course is abrupt and comparatively similar to other types of cardiomyopathy. [ncbi.nlm.nih.gov] The therapy of cocaine-induced cardiomyopathy is similar to the way that other types of cardiomyopathy are managed. [bmcresnotes.biomedcentral.com] Limb-Girdle Muscular Dystrophy […] symptoms Weakness: Proximal Serum CK: High but lower than average Pain syndrome Onset: Distal leg (calf) painful swelling without weakness or atrophy Unilateral or Bilateral [neuromuscular.wustl.edu] This may manifest as hypertrophic/dilated cardiomyopathy and cardiac dysrhythmias. [circheartfailure.ahajournals.org] This is the first report showing the electron microscopic findings of dilated cardiomyopathy (DCM) accompanied with limb girdle muscular dystrophy. [ncbi.nlm.nih.gov] Friedreich Ataxia […] and impaired coordination) of all limbs Bilateral lower limbs equally affected Wide-based steppage gait with dysmetria and frequent falling Titubation while standing or sitting [amboss.com] They may develop a cardiomyopathy (CM) phenotype, which is similar to hypertrophic cardiomyopathy and potentially progresses towards a life-limiting problem. [escardio.org] […] other cardiomyopathies have been associated with mortality). [circ.ahajournals.org] Dermatomyositis Neurological examination revealed bilateral symmetric muscle weakness affecting the shoulders and hip girdle muscles, with strength assessed at 3 of 5 bilaterally. [reumatologiaclinica.org] […] due to dermatomyositis Dilated cardiomyopathy secondary to dermatomyositis Disorder of respiratory system due to dermatomyositis Juvenile dermatomyositis Juvenile dermatomyositis [icd9data.com] Session Title: FIT Clinical Decision Making: Heart Failure and Cardiomyopathies 1 Abstract Category: Heart Failure and Cardiomyopathies Presentation Number: 1111-121 2019 [onlinejacc.org] Facioscapulohumeral Muscular Dystrophy The patient had moderate facial weakness and marked winging and high-riding of the scapulae with prominent pectoral and proximal arm muscle atrophy and weakness. [ncbi.nlm.nih.gov] This is the first report of an FSHD patient with biopsy-proven cardiomyopathy. [ncbi.nlm.nih.gov] A 50-year-old man was referred for bilateral arm and shoulder girdle weakness since 25 years of age and slowly progressive ptosis without double vision throughout his lifetime [jamanetwork.com] Stroke […] hemianopia 4 Facial movement 0—Normal 1—Minor facial weakness 2—Partial facial weakness 3—Complete unilateral palsy 5 Motor function (arm) 0—No drift a. [doi.org] We are reporting a case of acute stroke in a young patient with severe ischaemic cardiomyopathy in the absence of traditional risk factors. [ncbi.nlm.nih.gov] BACKGROUND: Stroke is a recognized clinical course of hypertrophic cardiomyopathy. [ncbi.nlm.nih.gov] Wilson Disease The abductor pollicis brevis, first dorsal interosseous, other intrinsic hand muscles, and toe and feet muscles were weak (Medical Research Council [MRC] grade IV+/IV+) bilaterally [jamanetwork.com] Cardiac injury may include arrhythmia, cardiomyopathy, and autonomic dysfunction. [ncbi.nlm.nih.gov] These are presumably related to underlying cardiomyopathy due to deposition of copper in heart which can be quantified by cardiac magnetic resonance imaging (MRI) and echocardiography [ncbi.nlm.nih.gov] Amyotrophic Lateral Sclerosis Here, we report a patient who presented with progressive left arm weakness and was found to have bilateral MRI plexus abnormalities. [ncbi.nlm.nih.gov] We report the case of early recurrence of Tako-Tsubo cardiomyopathy in an elderly woman with amyotrophic lateral sclerosis triggered by different stressors. [ncbi.nlm.nih.gov] Regionally isolated variants of ALS include flail arm syndrome, which involves bilateral proximal and typically predominant LMN arm weakness, and the flail leg syndrome, characterized [doi.org] Werner Syndrome Other symptoms include change in voice (weak, hoarse, high-pitched), atrophy of gonads leading to reduced fertility, bilateral cataracts (clouding of lens), premature arteriosclerosis [en.wikipedia.org] 1A Dilated cardiomyopathy 1A Dilated cardiomyopathy 1AA Dilated cardiomyopathy 1BB Dilated cardiomyopathy 1C Dilated cardiomyopathy 1D Dilated cardiomyopathy 1E Dilated cardiomyopathy [pentacorelab.hu] 11 Dilated cardiomyopathy 1AA DFNA20 Nemaline myopathy 3 Myosin Elejalde syndrome Hypertrophic cardiomyopathy 1, 8, 10 Usher syndrome 1B Freeman–Sheldon syndrome DFN A3, [en.wikipedia.org] Hereditary Proximal Myopathy with Early Respiratory Failure Neurologic exam revealed thinning of the anterior legs, bilateral calf hypertrophy, neck flexor and extensor weakness, distal greater than proximal weakness in the legs, and [neurology.org] A common heart problem caused by variants in the Titin gene is known as dilated cardiomyopathy. [titinmyopathy.com] The cardiomyopathy can precede the myopathy ( Calderon et al 1987 ; Goebel et al 1994 ). [medlink.com] Bilateral Leg Weakness arm weakness. [n.neurology.org] […] data Type II fiber atrophy; lymphocytic vasculitis; myositis Genetic Becker muscular dystrophy Hip; proximal leg and arm Late childhood to adulthood Mental retardation; cardiomyopathy [aafp.org] The most common cause of bilateral weakness is injury. This can occur either to the spinal cord, muscles in both arms or both legs, or to the spine itself. [wisegeekhealth.com] Nemaline Myopathy There was bilateral facial weakness, as well as proximal and distal wasting and weakness in the arms and legs. [ncbi.nlm.nih.gov] The combination of nemaline myopathy and cardiomyopathy is rare, and this is the first reported case of dilated cardiomyopathy associated with childhood-onset nemaline myopathy [ncbi.nlm.nih.gov] B Atrophy of the proximal arm muscles, neck muscles, and weakness of the facial muscles. C Bilateral hand wasting Fig. 20. Nemaline myopathy. [rrnursingschool.biz] Bezold's Abscess Case A 73-year-old male patient who was known case of diabetes, hypertension, renal impairment, and cardiomyopathy presented to our clinic with 1-week history of the right [indianjotol.org] Cervical Osteoarthritis either unilateral or bilateral. 3) Muscle weakness: Depending on which nerve root gets compressed, the concerned muscles that are supplied by that nerve root gets affected [physiotherapy-treatment.com] […] affected by the pathology. a) Upper cervical spine- Headache b) Mid cervical spine- Neck pain c) Region from C4 to T2- Radiating pain; pain in shoulder girdle, shoulder and arm [physiotherapy-treatment.com] Multifocal Motor Neuropathy […] hereditary cancer), 비유전성 혈액암(hematologic malignancy), 유전성 갑상선저하증(hereditary hypothyroidism), 리보좀축적질환(lysosomal storage disease), 유전성뇌전증(epilepsy), 유전성부정맥(arrhythmia), 유전성심근병증(cardiomyopathy [m.blog.naver.com] Upper Limb Hypertrophy […] as late effects of cerebrovascular accident Weakness of arm Weakness of bilat arms Weakness of bilat legs Weakness of bilateral legs Weakness of both arms Weakness of extremities [icd9data.com] LGMD2I is also associated with cardiomyopathy and respiratory abnormalities. [rarediseases.org] Patient’s face showed gross lipodystropy, wasting of sternmastoid muscles and upper arms muscles, bilaterally ( figure 4A-4D ). [omicsonline.org] Distal Myopathy Type 3 weakness H/o HTN, dyslipidaemia DM Weakness of the involved arm Head CT Normal Normal Neuropathic GBS [27] 18 −350 Proximal − − − + − − + − Ascending paralysis Precedes a [wikidoc.org] The cardiomyopathy phenotype is usually classified as dilated cardiomyopathy (DCM) but also ARVC and hypertrophic cardiomyopathies (HCM) have been described. [blueprintgenetics.com] Article Article Article Article Brève Article Article Article Article Article Article Article GeneReviews® [Internet] Dilated Cardiomyopathy Overview Initial Posting: July [myobase.org] Cardiogenic Syncope […] or pain, severe back pain), unstable medical conditions, inability to obtain blood pressure (incompressible arm arteries, bilateral arm AV fistula, bilateral subclavian artery [clevelandclinicmeded.com] Hypertrophic Cardiomyopathy Causes Hypertrophic cardiomyopathy is an inheritable disease. [umms.org] […] dilated cardiomyopathy, hypertrophic cardiomyopathy, restrictive cardiomyopathy, and left ventricular non-compaction cardiomyopathy. [metisgenetics.com] Syncope […] or pain, severe back pain), unstable medical conditions, inability to obtain blood pressure (incompressible arm arteries, bilateral arm AV fistula, bilateral subclavian artery [clevelandclinicmeded.com] Syncope in Other Forms of Structural Heart Disease Hypertrophic Cardiomyopathy Hypertrophic cardiomyopathy is a relatively frequent (1 in 500 individuals), genetically determined [doi.org] 5.6.4 Arrhythmogenic right ventricular cardiomyopathy 5.6.5 Patients with inheritable arrhythmogenic disorders 6. [escardio.org] Congenital Fiber-Type Disproportion Myopathy B Atrophy of the proximal arm muscles, neck muscles, and weakness of the facial muscles. C Bilateral hand wasting Fig. 20. Nemaline myopathy. [rrnursingschool.biz] Examination of the heart from patient 1 at the time of transplantation confirmed dilated cardiomyopathy with hypertrophic myocardiocytes. [ncbi.nlm.nih.gov] There was mild proximal upper limb weakness, mainly affecting arm elevator and triceps muscles. Bicipital, tricipital and knee DTRs were absent. [academic.oup.com] Native American Myopathy Neurologic exam revealed thinning of the anterior legs, bilateral calf hypertrophy, neck flexor and extensor weakness, distal greater than proximal weakness in the legs, and [neurology.org] Basso C, Corrado D, Thiene G (2010) Arrhythmogenic right ventricular cardiomyopathy: what’s in a name? [link.springer.com] Cardiomyopathy. [jci.org] Nemaline Myopathy Type 5 weakness H/o HTN, dyslipidaemia DM Weakness of the involved arm Head CT Normal Normal Neuropathic GBS [27] 18 −350 Proximal − − − + − − + − Ascending paralysis Precedes a [wikidoc.org] Cardiomyopathy has not been observed in association with ANM in previous reports. [nlm.medscape.idmu.unboundmedicine.unboundmedicine.com] ACTA1 childhood onset dilated cardiomyopathy nemaline myopathy neuromuscular diseases school-aged child Abbreviations: DCM — dilated cardiomyopathy HCM — hypertrophic cardiomyopathy [pediatrics.aappublications.org] Rigid Spine Syndrome Central cord syndrome in a 77-year-old man with DISH who fell down stairs and presented with sensory deficit and bilateral arm and leg weakness. [pubs.rsna.org] J Neurol Neurosurg Psychiatry 44:1146–1152 Google Scholar Colver AF, Steer CR, Goodman MV, Uttley WS (1981) Rigid spine syndrome and fatal cardiomyopathy. [link.springer.com] Dilated cardiomyopathy in multicore myopathy. Am J Cardiol. 1989;63:150–151. doi: 10.1016/0002-9149(89)91108-9. [ncbi.nlm.nih.gov] Orthostatic Syncope […] or pain, severe back pain), unstable medical conditions, inability to obtain blood pressure (incompressible arm arteries, bilateral arm AV fistula, bilateral subclavian artery [clevelandclinicmeded.com] Diurnal change in QT intervals in dilated cardiomyopathy and hypertrophic cardiomyopathy. [journals.plos.org] Ventricular Cardiomyopathy and Other Cardiomyopathies, and Myocarditis: A Scientific Statement From the American Heart Association and American College of Cardiology. [acc.org]