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43 Possible Causes for Bilateral Leg Weakness, Chronic Denervation

  • Multifocal Motor Neuropathy

    RESULTS: In this case of MMN without conduction blocks we found multifocal nerve enlargements in the ultrasonography and electrodiagnostic signs of acute and chronic denervation[ncbi.nlm.nih.gov] The most important of these findings are the reinnervation motor unit action potentials seen together with chronic denervated motor unit action potentials and this makes an[marmaramedicaljournal.org] Over the years, new CBs developed, which led to tetraplegia, and amyotrophy slowly increased with progressive denervation.[doi.org]

  • Paresis

    After tracheal extubation, she exhibited bilateral leg weakness that did not resolve over the next 4-6h.[ncbi.nlm.nih.gov] Electromyography revealed acute denervation in territories corresponding to L3-L4 and moderate widespread axonal polyneuropathy affecting both lower limbs.[ncbi.nlm.nih.gov] He had bilateral leg weakness: 4/5 power in the right leg and 1/5 power at the left knee and hip.[racgp.org.au]

  • Hereditary Proximal Myopathy with Early Respiratory Failure

    Neurologic exam revealed thinning of the anterior legs, bilateral calf hypertrophy, neck flexor and extensor weakness, distal greater than proximal weakness in the legs, and[neurology.org] denervation: Some patients NCV: Normal Muscle biopsy Atrophy: Regional Hypertrophy: Scattered muscle fibers Increased Endomysial connective tissue: Patchy Rimmed vacuoles[neuromuscular.wustl.edu] […] progressed to prominent distal weakness and respiratory insufficiency (FVC of 29%).[neurology.org]

  • Primary Lateral Sclerosis

    Neurologic examination at that time revealed mild hip and ankle flexor weakness, with bilateral leg spasticity, but no sensory loss or ataxia.[ncbi.nlm.nih.gov] Patients with PLS demonstrated no evidence of acute or chronic denervation on EMG/NCS.[doi.org] These may be considered as signs of chronic denervation caused by slow lower motor neuron loss.[jnnp.bmj.com]

  • Adult Polyglucosan Body Disease

    […] of the feet, and proximal leg weakness.[theassr.org] The neuropathy manifested by absent sural nerve and posterior tibial and peroneal motor responses and by evidence of chronic denervation with reinnervation changes predominantly[thefreelibrary.com] Results A 50 year-old male of Ashkenazi Jewish descent presented with a three year history of progressive gait unsteadiness, bladder urgency and frequency, bilateral paresthesias[theassr.org]

  • Amyotrophic Lateral Sclerosis 5

    Results Clinical Features The patient (IV-1) was a 24-year-old male who developed walking difficulties due to leg weakness beginning at 16 years of age and exhibited atrophy[journal.frontiersin.org] Electromyography showed distal more than proximal chronic partial denervation and reinnervation (n 8).[jhu.pure.elsevier.com] Neurophysiological examination demonstrated chronic and active denervation in the lower limbs, as well as denervation potentials in the thoracic muscles.[atm.amegroups.com]

  • Autosomal Dominant Spastic Paraplegia Type 13

    leg spasticity and weakness.[journals.lww.com] Electromyography sampling revealed mild chronic denervation features.[sudanmedicalmonitor.org] .0000293721.86238.6a Article Article Related Links Abstract Hereditary spastic paraplegia (HSP) is a clinically and genetically heterogeneous group of motor disorders characterized by bilateral[journals.lww.com]

  • Sacral Radiculopathy

    Manifestations include bilateral leg weakness and sensory symptoms, and loss of bowel or bladder control.[clevelandclinicmeded.com] chronic) in myotomal S1 muscles, respectively.[ncbi.nlm.nih.gov] […] motor units in more chronic radiculopathies.[ipfs.io]

  • Inclusion Body Myositis

    X-rays of the knee joints and lower legs showed bilateral recurvatum deformity (hyperextension) and gross mediolateral instability, caused by quadriceps weakness.[mja.com.au] An older age-at-onset was associated with a more rapid progression, and patients with a longer duration frequently showed F-wave abnormalities and findings of chronic denervation[ncbi.nlm.nih.gov] On physical examination, his eye movements were full but bilateral weakness of his orbicularis oculi was evident.[jmedicalcasereports.com]

  • Carotid Sinus Syncope

    The isoproterenol tilt testing is contraindicated in patients with ischemic heart disease. 2 Limitations to the head-up tilt test include: inability to stand (leg weakness[clevelandclinicmeded.com] Chronic denervation of the sternocleidomastoid muscles is common in elderly patients with (CSH), and is proposed to interfere with normal integration of afferent firing from[physreports.physiology.org] […] or pain, severe back pain), unstable medical conditions, inability to obtain blood pressure (incompressible arm arteries, bilateral arm AV fistula, bilateral subclavian artery[clevelandclinicmeded.com]

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