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35 Possible Causes for Bilateral Leg Weakness, Dark Urine

  • Glycogen Storage Disease Type 2

    INTRODUCTION: Pompe disease is a rare, autosomal recessive disorder caused by deficiency of the glycogen-degrading lysosomal enzyme acid alpha-glucosidase. Late-onset Pompe disease is a multisystem condition, with a heterogeneous clinical presentation that mimics other neuromuscular disorders. METHODS: Objective is[…][ncbi.nlm.nih.gov]

  • Vitamin B12 Deficiency

    She presented with memory loss and progressive leg weakness. Her legs were hypotonic with decreased power, absent reflexes and bilateral extensor plantar reflexes.[ageing.oxfordjournals.org]

  • Rhabdomyolysis

    , bilateral leg pain, and recurrent falls.[ncbi.nlm.nih.gov] As no erythrocytes in the microscopic examination of the urine and hemoglobinuria were present, myoglobinuria due to rhabdomyolysis was the most probable cause of dark urine[ncbi.nlm.nih.gov] Symptoms of rhabdomyolysis include dark urine, muscle weakness and fatigue. Statins are the most commonly used drugs for prevention and management of dyslipidemia.[ncbi.nlm.nih.gov]

  • Paroxysmal Rhabdomyolysis

    She had tenderness and weakness in upper parts of her legs and bilateral flank pain.[link.springer.com] […] a·cute re·cur·rent rhab·do·my·ol·y·sis [MIM*268200] repeated paroxysmal attacks of muscle pain and weakness followed by passage of dark red-brown urine, often precipitated[medical-dictionary.thefreedictionary.com] Patients suffered generalized weakness, inability to walk, myalgia, muscle weakness, and dark urine. All patients appeared healthy in between episodes.[cags.org.ae]

  • Liver Cirrhosis

    A 65-year-old male with liver cirrhosis of alcoholic etiology was admitted to hospital with bilateral leg edema, ascites, and marked weakness.[ncbi.nlm.nih.gov] If you notice symptoms of liver damage (such as jaundice, dark urine, or pain in your abdomen) speak to your doctor and let her know about any drugs you may be taking.[health.com] urine pale-coloured stools or very dark/black tarry stools frequent nosebleeds and bleeding gums easy bruising and diffi culty in stopping small bleeds vomiting blood frequent[britishlivertrust.org.uk]

  • Sacral Radiculopathy

    PATIENT AND METHODS: The patient complained of a rapid painless weakness in legs, after intense and prolonged cycling 4 months ago.[ncbi.nlm.nih.gov] Urine 526 Case 84 A Woman with Progressive Proximal Muscle Weakness 533 Case 85 A Sedentary Man with Acute Respiratory Failure and Myoglobinuria 539 Case 86 A Uremic Man[books.google.de] OBJECTIVE-PURPOSE: The purpose of this case report is to describe a gait disorder presenting as a bilateral sacral radiculopathy after vigorous cycling.[ncbi.nlm.nih.gov]

  • Oculopharyngodistal Myopathy

    We report here a 43-year old woman with asymmetric bilateral ptosis, dysphonia, swallowing difficulties, and weakness of the distal leg muscles.[ncbi.nlm.nih.gov] Urine 526 Case 84 A Woman with Progressive Proximal Muscle Weakness 533 Case 85 A Sedentary Man with Acute Respiratory Failure and Myoglobinuria 539 Case 86 A Uremic Man[books.google.com] Oculopharyngodistal myopathy is an extremely rare disease characterised by slowly progressive blepharoptosis, facial and bulbar muscle weakness and distal leg myopathy.[ncbi.nlm.nih.gov]

  • Low Back Pain

    leg weakness) Pearls: *Constant, unrelenting, severe pain, especially if it is worse lying down is a red flag for infection or cancer.* Discogenic pain is worse with flexion[emergencymedicinecases.com] Your urine should be clear or light yellow; if it’s dark yellow, grab some H20.[rd.com] […] resovled by analgesia, History of trauma or coagulopathy, Cauda equina/cord compression symptoms (bowel, bladder or erectile dysfunction, saddle paresthesia, progressive bilateral[emergencymedicinecases.com]

  • Mononeuritis

    He had bilateral claw hand and foot drop with grade 0 weakness in both distal legs.[annalsofian.org] Urine 526 Case 84 A Woman with Progressive Proximal Muscle Weakness 533 Case 85 A Sedentary Man with Acute Respiratory Failure and Myoglobinuria 539 Case 86 A Uremic Man[books.google.com] On examination, he had pedal edema and scattered erythematous rashes over back, buttock, right leg, and right forearm without nerve thickening.[annalsofian.org]

  • Hereditary Proximal Myopathy with Early Respiratory Failure

    Neurologic exam revealed thinning of the anterior legs, bilateral calf hypertrophy, neck flexor and extensor weakness, distal greater than proximal weakness in the legs, and[neurology.org] In metabolic myopathies associated with rhabdomyolysis (defined as creatine kinase elevation 10 times the normal value), patients may report tea-colored or dark urine, especially[clevelandclinicmeded.com] […] progressed to prominent distal weakness and respiratory insufficiency (FVC of 29%).[neurology.org]

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