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248 Possible Causes for Bilateral Leg Weakness, Hydrocephalus

  • Hereditary ATTR Amyloidosis

    Typical clinical central nervous system manifestations include cerebral infarction and hemorrhage, hydrocephalus, ataxia, spastic paralysis, convulsion, and dementia.[]

  • Carnitine Deficiency

    Our son, sweet 1 lb 1.4 ounce, 12 inches long, teeny, tiny little Joseph “Hamilton” Jones was born with spina bifida, hydrocephalus, and a heart defect.[] We describe a case of a 35-year-old woman who presented with bilateral leg weakness and encephalopathy while on long-term valproate therapy.[]

  • Meningioma

    They often cause obstructive hydrocephalus and commonly are treated with surgical resection or stereotactic radiosurgery.[] Large parasagittal meningiomas may result in bilateral leg weakness.[] The authors present the case of a 56-year-old patient who presented with a large petroclival meningioma and clinical symptoms of brainstem compression and hydrocephalus.[]

  • Ependymoma

    Magnetic resonance imaging on admission revealed an intradural extramedullary cystic lesion at the cervical level with craniospinal leptomeningeal nodules causing mild hydrocephalus[] Eric Kratky In January 2007, Erik Kratky was 21 and pursuing his undergraduate degree when he experienced bilateral leg weakness.[] On brain MRI a posterior third ventricle lesion with extension to the aqueduct of Sylvius and fourth ventricle, and associated hydrocephalus was observed.[]

  • Neuroectodermal Tumor

    Imaging showed acute hydrocephalus and mild diffuse leptomeningeal enhancement without an identifiable primary lesion.[] A 14-year-old teenage girl had suffered from progressive left upper back pain with bilateral lower legs weakness and numbness for 1 year.[] He was evaluated for low backache and occipital headache 2½ years earlier and was found to have communicating hydrocephalus on CT scan.[]

  • Drop Attacks

    A single embolus may lodge in this common vessel which then results in bilateral leg weakness.[] The causative lesion was a contrast-enhancing, partially cystic third ventricular mass, which ultimately obstructed the aqueduct, producing profound obstructive hydrocephalus[] Bilateral leg weakness can result if both arteries have a common origin, an anomaly in about 20% of individuals Questions 3.12 : Orthostatic hypotension is rarely a cause[]

  • Lyme Neuroborreliosis

    The syndrome of normal-pressure hydrocephalus (NPH) fully remitted after ceftriaxone treatment.[] leg weakness, urinary retention, and sensory abnormalities, can mimic such diseases as Guillain-Barré, multiple sclerosis, and acute disseminated encephalomyelitis and lead[] […] include transverse myelitis, plexopathies, mononeuropathy multiplex, and complex mononeuropathy multiplex. 8 , 11 These syndromes, which can have such varying presentations as bilateral[]

  • Sagittal Sinus Thrombosis

    However, hydrocephalus associated with cerebral sinus thrombosis is rare.[] In addition, thrombosis of the superior sagittal sinus classically presents with bilateral leg weakness, as the superior sagittal sinus is midline.[] Three of the heparin group patients developed complications of the underlying disease (status epilepticus, hydrocephalus, refractory papilledema). No deaths occurred.[]

  • Cerebral Malaria

    An 84-year-old Somali woman presented with a 3-day history of altered mental status, spiking fevers, chills, bilateral leg pain and weakness, and intermittent diarrhea.[] We describe a 7-month-old child with cerebral malaria for whom cerebellar edema and obstructive hydrocephalus were initial radiologic findings.[] However, in its severe form, PRES can be associated with death and disability; posterior fossa edema causing obstructive hydrocephalus is one of the postulated causes of persisting[]

  • Arteriovenous Fistula

    […] neurological conditions we treat: Alzheimer’s Disease / Dementia CSF Leak Cerebrospinal fluid diverting shunts Cerebrospinal fluid leak Intracraneal hypotension Normal pressure hydrocephalus[] A 14-year-old girl presented with a 3-week history of slowly progressive unilateral leg weakness that quickly progressed to bilateral leg paralysis, sphincter dysfunction,[] These fistulas can cause cardiac failure , hydrocephalus , or damage to the developing brain.[]

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