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106 Possible Causes for Bilateral Leg Weakness, Hyperreflexia, Myopathy

  • Multifocal Motor Neuropathy

    Atrophy may be present, but hyperreflexia and spasticity are not seen.[ncbi.nlm.nih.gov] 遠位型ミオパチー Distal Myopathy 遠位型ミオパチー 1 不要 有 HPS2971 HPS2972 HPS2973 HPS2974 HPS2975 HPS2976 Distal Myopathy, DMRV / GNE myopathy 遠位型ミオパチー、縁取り空胞を伴う遠位型ミオパチー(GNE遺伝子変異) 1 不要 有 HPS1436[cell.brc.riken.jp] MMN can usually be distinguished from ALS by its more slowly progressive disease course, the absence of upper-motor-neuron signs such as spasticity and hyperreflexia and the[mmcneuro.wordpress.com]

  • Spinal Epidural Abscess

    Massive Disc Herniation, Spinal Epidural Abscess or Bony Metastasis) Vertebral Fractures, Osteomyelitis Cauda Equina Syndrome (CES) Note - Cord Compression is a UMN lesion (Hyperreflexia[emdidactic.blogspot.com] […] below level of injury, strength/sensory testing identifies level Bilateral weakness, proximal groups Lesion: Muscle Causes: Rhabdomyolysis, polymyositis, dermatomyositis, myopathies[ddxof.com] A patient’s reflexes may vary from being absent to hyperreflexia with clonus (rhythmic muscle spasms or contractions) and extensor plantar responses (a/k/a Babinski responses[matzuslaw.com]

  • Amyotrophic Lateral Sclerosis 3

    The fact that hyperreflexia may be detected in regions of muscle atrophy is considered to be highly indicative of ALS.[symptoma.com] […] in the NCS and EMG may suggest, for example, that the individual has a form of peripheral neuropathy (damage to peripheral nerves outside of the brain and spinal cord) or myopathy[ninds.nih.gov] Hyperreflexia and an increase of muscle tone are most characteristic and may be detected in muscles of face, larynx and pharynx (bulbar region), neck, arms, and diaphragm[symptoma.com]

  • Spinal Metastasis

    A 63-year-old man presented with acute back pain and bilateral leg weakness 5 months after having a surgical treatment for moderately differentiated vocal cord squamous cell[ncbi.nlm.nih.gov] […] arising either during the night and early morning or due to movement, is by far the most frequently reported symptom, accompanied by pain or weakness in the extremities, hyperreflexia[symptoma.com] Treatment of spinal metastases, including chemotherapy, hormonal therapy, and radiation therapy, may cause peripheral neuropathy, myopathy, and osteoporosis, increasing the[ascopost.com]

  • Autosomal Recessive Spastic Paraplegia Type 14

    leg spasticity and weakness.[journals.lww.com] Hyperreflexia of the lower as well as the upper limbs was also observed. Brain MRI findings were similar to that of patient II3.[omicsonline.org] 4 Navajo Neurohepatopathy 2 Naxos Disease 2 Nemaline Myopathy 1 4 Nemaline Myopathy 10 4 Nemaline Myopathy 2 6 Nemaline Myopathy 3 5 Nemaline Myopathy 4 5 Nemaline Myopathy[preventiongenetics.com]

  • Myelopathy

    A 14-year-old girl presented with a 3-week history of slowly progressive unilateral leg weakness that quickly progressed to bilateral leg paralysis, sphincter dysfunction,[ncbi.nlm.nih.gov] Clinical hyperreflexia was tested at the MCP joint, using a six-axis load cell.[ncbi.nlm.nih.gov] Myelopathy Versus Myopathy Myopathy is a muscular disorder and should not be confused with myelopathy, which has to do with nerve damage inside the spinal cord.[hopkinsmedicine.org]

  • Primary Lateral Sclerosis

    Neurologic examination at that time revealed mild hip and ankle flexor weakness, with bilateral leg spasticity, but no sensory loss or ataxia.[ncbi.nlm.nih.gov] […] disease; a slowly progressive degenerative disorder of the motor neurons of the cerebral cortex, resulting in widespread weakness on an upper motor neuron basis; spasticity, hyperreflexia[medical-dictionary.thefreedictionary.com] It tends to cause proximal weakness and may be confused with myopathy. The changes of denervation are obvious in the muscle biopsy.[web.archive.org]

  • Amyotrophic Lateral Sclerosis 6

    Besides these lower motor neuron signs, upper motor neuron signs are characteristic of ALS: ALS patients suffer from hyperreflexia and present with an increased muscle tone[symptoma.com] […] in the NCS and EMG may suggest, for example, that the individual has a form of peripheral neuropathy (damage to peripheral nerves outside of the brain and spinal cord) or myopathy[ninds.nih.gov]

  • Amyotrophic Lateral Sclerosis

    Regionally isolated variants of ALS include flail arm syndrome, which involves bilateral proximal and typically predominant LMN arm weakness, and the flail leg syndrome, characterized[doi.org] […] remains normal Physical exam neck ptosis (neck drop) due to neck extensor weakness manual muscle testing elicits muscle cramping upper motor neuron (UMN) signs spasticity hyperreflexia[orthobullets.com] Mutations in the valosin-containing protein (VCP) gene were first found to cause inclusion- body myopathy with early-onset Paget disease and frontotemporal dementia (IBMPFD[ncbi.nlm.nih.gov]

  • Autosomal Recessive Spastic Paraplegia Type 46

    leg spasticity and weakness.[journals.lww.com] Affiliated tissues include brain , and related phenotypes are nystagmus and hyperreflexia Disease Ontology : 12 A hereditary spastic paraplegia that has material basis in[malacards.org] About 20% of DOA patients harbour extraocular multi-systemic features, including neurosensory hearing loss, or less commonly chronic progressive external ophthalmoplegia, myopathy[ncbi.nlm.nih.gov]

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