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10 Possible Causes for Bilateral Leg Weakness, Muscle Biopsy showing Presence of Vacuoles

  • Glycogen Storage Disease Type 2

    Muscle biopsy in Pompe disease shows the presence of vacuoles that stain positively for glycogen.[dx.doi.org] Quantitatively, muscle glycogen content is elevated up to tenfold above normal in infantile Pompe disease and to a lesser extent in late onset patients.[dx.doi.org] Furthermore, there is anesthesia risk (see section below) in infantile Pompe disease if an open biopsy is done. 26 This risk should be carefully considered, particularly if[dx.doi.org]

  • Hypokalemic Periodic Paralysis

    The commonest sites are legs. The less common severe forms of disease present with generalized weakness/ complete paralysis. They are acute or insidious in onset.[explainmedicine.com] The weakness is usually bilateral, and may spread to the proximal parts of the upper limbs, trunk and neck later.[explainmedicine.com]

  • Myositis

    Muscle-strength tests revealed bilateral trivial gastrocnemius weakness with myalgia.[ncbi.nlm.nih.gov] In inclusion body myositis, findings on muscle biopsy may show the presence of vacuolated muscle fibers with basophilic granular deposits, the presence of varying degrees[rheumatologyadvisor.com] Additionally, lower leg magnetic resonance imaging and gastrocnemius muscle biopsy revealed inflammatory myositis mimicking polymyositis.[ncbi.nlm.nih.gov]

  • Proximal Myopathy with Extrapyramidal Signs

    The condition is associated with bilateral leg weakness and hyperreflexia. Causes include spinal cord lesions and bilateral cerebral hemisphere abnormalities.[patient.info] Muscle biopsy shows the presence of vacuoles, containing glycogen, in muscle fibers, which are present during an attack, and which may decrease in number immediately after[intranet.tdmu.edu.ua] Beware mild ophthalmoparesis and bilateral facial weakness. Both are easily missed and should be specifically sought during the examination.[jnnp.bmj.com]

  • Inclusion Body Myositis

    X-rays of the knee joints and lower legs showed bilateral recurvatum deformity (hyperextension) and gross mediolateral instability, caused by quadriceps weakness.[mja.com.au] Muscle biopsy will also show rimmed vacuoles (abnormal cellular structures that are also called inclusion bodies), amyloid deposits (presence of abnormal proteins), and endomysial[hss.edu] In 2010, the patient presented with chronic proximal leg and distal arm asymmetric muscle weakness.[karger.com]

  • Fingerprint Body Myopathy

    A Distal leg atrophy in a patient with nemaline myopathy. B Atrophy of the proximal arm muscles, neck muscles, and weakness of the facial muscles.[rrnursingschool.biz] Interattack muscle biopsies show the presence of single or multiple centrally placed vacuoles or tubular aggregates.[basicmedicalkey.com] C Bilateral hand wasting Fig. 20. Nemaline myopathy. A Large nemalin rod inclusions (arrows) on Trichrome stain.[rrnursingschool.biz]

  • Carcinomatous Myopathic Syndrome

    Case report A 69 year old man developed progressively deteriorating bilateral proximal muscular weakness of the legs that within 6 months led to paraparesis, with complete[jtd.amegroups.com] Muscle biopsy shows inflammation of muscle, fibre necrosis and the presence of vacuoles and filamentous inclusions in fibres (seen by electron microscopy).[somalidoc.com]

  • Myopathy, Endocrine

    Cauda equina compression (syndrome) is suggested by flaccid weakness of the legs, often with urinary retention or overflow incontinence.[dartmouth.edu] Muscle biopsy shows inflammation of muscle, fibre necrosis and the presence of vacuoles and filamentous inclusions in fibres (seen by electron microscopy).[somalidoc.com] In inclusion body myositis, findings on muscle biopsy may show the presence of vacuolated muscle fibers with basophilic granular deposits, the presence of varying degrees[rheumatologyadvisor.com]

  • Distal Myopathy with Anterior Tibial Onset

    […] ptosis as the dominant symptom, which differed from the main complaint of lower leg weakness reported by our patients [ 5 ].[journals.plos.org] , modest elevation of serum creatine kinase (2-5x), muscle biopsy showing fiber size variation (with atrophy) and presence of rimmed vacuoles and congophilic protein aggregates[orpha.net] Weakness of finger extensors develops between months and several decades after the onset of leg weakness [ Lamont et al 2014 ].[ncbi.nlm.nih.gov]

  • Vacuolar Neuromyopathy

    The presenting complaint is bilateral leg weakness that leads to difficulty with walking. Symptoms progress rapidly over several weeks.[hivinsite.ucsf.edu] A muscle biopsy of the right deltoid showed an increased size variability, fibre splitting, and the presence of internal nuclei; several fib res (8%) contained vacuoles ([functionalneurology.com] […] lymphoma.(51-53) Manifestations Progressive polyradiculopathy has a striking predilection for the lumbosacral roots, leading to neurologic deficits that are limited to the legs[hivinsite.ucsf.edu]

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