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146 Possible Causes for Bilateral Leg Weakness, Syncope

  • Adrenal Insufficiency

    A 65-year-old male with liver cirrhosis of alcoholic etiology was admitted to hospital with bilateral leg edema, ascites, and marked weakness.[ncbi.nlm.nih.gov] A 66-year-old man, chronic smoker, presented with episodes of syncope, hypotension and constitutional symptoms.[ncbi.nlm.nih.gov] Of 65 serious AEs reported by 32 patients (20 per 100 patient-years), four were considered to be possibly related to DR-HC: acute AI (n   2), gastritis (n   1) and syncope[ncbi.nlm.nih.gov]

  • Brain Neoplasm

    Large parasagittal meningiomas may result in bilateral leg weakness.[brighamandwomens.org] […] renal transplantation in February 2003 and was taking an immunosuppressive regimen of mycophenolate mofetil and cyclosporine was seen in the emergency department after a syncopal[ncbi.nlm.nih.gov]

  • Hereditary ATTR Amyloidosis

    […] congestive heart failure, including: Shortness of breath Labored breathing during exercise Peripheral swelling ( edema caused by a buildup of fluid in the lower limbs) Fainting ( syncope[pfizer.com] […] exertion palpitations and abnormal heart rhythms, most frequently atrial fibrillation or atrial flutter leg swelling (oedema) weight loss nausea fatigue dizziness and collapse (syncope[amyloidosis.org.uk] […] heart failure (ie, dyspnea on exertion, peripheral edema, elevated jugular venous pressure, hepatojuglular reflux) and/or arrhythmias (ie, palpitations, lightheadedness, syncope[emedicine.medscape.com]

  • Meningioma

    Large parasagittal meningiomas may result in bilateral leg weakness.[brighamandwomens.org] The patient presented with a history of several years of worsening headaches and blurry vision, which progressed to include syncopal episodes and right-sided weakness.[ncbi.nlm.nih.gov]

  • Drop Attacks

    A single embolus may lodge in this common vessel which then results in bilateral leg weakness.[brainscape.com] This report examines findings in consecutive elderly patients with drop attacks referred to a dedicated "syncope and falls" center. Thirty-five patients were included.[ncbi.nlm.nih.gov] Dysfunctional autonomic cardiovascular regulation may result in syncope. Syncope may be the primary presenting symptom of CM1: a syndrome termed Chiari drop attack.[ncbi.nlm.nih.gov]

  • Carnitine Deficiency

    We describe a case of a 35-year-old woman who presented with bilateral leg weakness and encephalopathy while on long-term valproate therapy.[ncbi.nlm.nih.gov] One mother with primary carnitine deficiency was reported to have a history of syncope that worsened during pregnancy, when plasma carnitine levels are physiologically lower[emedicine.medscape.com] This latter individual had experienced a few episodes of syncope since 13 years of age without understanding the etiology, and diagnosis was made retrospectively.[karger.com]

  • Cerebral Malaria

    An 84-year-old Somali woman presented with a 3-day history of altered mental status, spiking fevers, chills, bilateral leg pain and weakness, and intermittent diarrhea.[ncbi.nlm.nih.gov]

  • Hypothyroidism

    , bilateral leg pain, and recurrent falls.[ncbi.nlm.nih.gov] Patient I presented with persistent respiratory distress, facial swelling and recurrent syncopal attacks.[ncbi.nlm.nih.gov] […] report a case of a 52-year-old Hispanic woman with a history of hypothyroidism, hypertension, and type 2 diabetes mellitus who presented with fatigue, severe generalized weakness[ncbi.nlm.nih.gov]

  • Sagittal Sinus Thrombosis

    In addition, thrombosis of the superior sagittal sinus classically presents with bilateral leg weakness, as the superior sagittal sinus is midline.[casemed.case.edu] CASE REPORT A 27-year-old right-handed man with a smoking history presented with syncope followed by headache.[jkns.or.kr]

  • Low Back Pain

    leg weakness) Pearls: *Constant, unrelenting, severe pain, especially if it is worse lying down is a red flag for infection or cancer.* Discogenic pain is worse with flexion[emergencymedicinecases.com] Manifestations include bilateral leg weakness and sensory symptoms, and loss of bowel or bladder control.[clevelandclinicmeded.com] […] lower leg; often bilateral Ache, shooting pain, “pins and needles” sensation Increased with walking, especially up an incline; decreased with sitting Mild decrease in extension[aafp.org]

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