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26 Possible Causes for Bile Acid Malabsorption in the Ileum

  • Diarrhea

    Bile acid diarrhea results from excessive amounts of bile acids entering the colon due to hepatic overexcretion of bile acids or bile acid malabsorption in the terminal ileum[ncbi.nlm.nih.gov] A 32-year-old woman with quiescent colonic Crohn's disease and a normal terminal ileum had been diagnosed with severe bile acid malabsorption and complained of watery diarrhea[ncbi.nlm.nih.gov] We report the use of the farnesoid X receptor agonist obeticholic acid in a patient with refractory bile acid diarrhea and subsequent intestinal failure.[ncbi.nlm.nih.gov]

  • Toddler's Diarrhea

    A congenital deficiency in the sodium–bile acid cotransporter results in primary bile acid malabsorption.[emedicine.medscape.com] Anaerobes and Staphylococcus aureus deconjugate bile acids, which impedes their active reabsorption by the terminal ileum into the portal circulation for reuptake by the liver[emedicine.medscape.com]

  • Recurrent Small Bowel Obstruction

    bile acid uptake from terminal ileum, dysmotility (possibly a prolonged orocaecal transit time), dehydration with inspissated secretions especially in hot weather (Mascarenhas[cfmedicine.com] Contributing factors include fat malabsorption, abnormal intestinal mucins, low duodenal pH, deficient anion secretion, dysregulation of sodium and chloride absorption, defective[cfmedicine.com]

  • Pediatric Crohn's Disease

    It is usually thought to be due to an inability of the ileum to reabsorb bile acids after resection of the terminal ileum and was the first type of bile acid malabsorption[en.wikipedia.org]

  • Primary Bile Acid Malabsorption

    Convincing evidence of the proposed pathophysiology--a defect of the active bile acid absorption in the distal ileum--has never been substantiated.[ncbi.nlm.nih.gov] Causes and symptoms of bile acid diarrhea Many diseases of the gut can cause bile acid malabsorption, especially diseases that affect the last part of the small intestine—the[belmarrahealth.com] Bile acid malabsorption has been divided into 3 types depending on aetiology: type 1: following ileal resection, disease or bypass of the terminal ileum type 2: primary idiopathic[nice.org.uk]

  • Short Bowel Syndrome

    The ileum is the site of vitamin B 12 and bile acid absorption. Severe diarrhea and bile acid malabsorption result when 100 cm of the ileum is resected.[merckmanuals.com] The ileum is the primary site for B12 and bile acid absorption, and so resection here may lead to B12 and fat malabsorption.[dontforgetthebubbles.com] […] of bile acids.[dx.doi.org]

  • Crohn's Disease

    It is usually thought to be due to an inability of the ileum to reabsorb bile acids after resection of the terminal ileum and was the first type of bile acid malabsorption[en.wikipedia.org]

  • Radiation-Induced Enteritis

    acid malabsorption Definition BAM is a defect in the enterohepatic circulation of bile acids.[doi.org] Two types of BAM exist: ileal dysfunction whereby the ability to absorb bile acids in the terminal ileum is impaired and secondly, hepatic overproduction that overwhelms terminal[doi.org] […] insufficiency (EPI) Carbohydrate malabsorption—for example, lactose or other disaccharide intolerance Pelvic floor dysfunction Small intestinal bacterial overgrowth (SIBO) Bile[doi.org]

  • Malabsorption Syndrome

    Intraluminal causes Pancreatic insufficiency [ 7 ] : Cystic fibrosis Chronic pancreatitis Carcinoma of pancreas Zollinger-Ellison syndrome Bile acid malabsorption : defective[patient.info] To diagnose bile acid malabsorption, which may occur with diseases of the terminal ileum (eg, Crohn disease, extensive resection of terminal ileum), patients can be given[msdmanuals.com] […] secretions of bile salts, due to cholestatic jaundice or disease of the terminal ileum.[patient.info]

  • Steatorrhea

    To diagnose bile acid malabsorption, which may occur with diseases of the terminal ileum (eg, Crohn disease, extensive resection of terminal ileum), patients can be given[msdmanuals.com] […] a therapeutic trial of a bile acid binding resin (eg, cholestyramine).[msdmanuals.com]

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