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185 Possible Causes for bilirubin, glucuronate

  • Crigler-Najjar Syndrome

    […] prolongation of the terminal half-life of radioactively labelled bilirubin and a fall in bilirubin clearance in every instance. 6.[ncbi.nlm.nih.gov] The present study documents a reduced biliary bilirubin secretion and suggests that the addition of the second glucuronic acid moiety to the bilirubin molecule may be defective[ncbi.nlm.nih.gov] The conjugation of bilirubin to glucuronate is catalyzed by the enzyme bilirubin-UDP-glucuronosyltransferase (bilirubin-UGT).[themedicalbiochemistrypage.org]

  • Gilbert's Disease

    Bilirubin IXalpha is recognised as a potent antioxidant.[ncbi.nlm.nih.gov] Pentose and glucuronate interconversions, organism-specific biosystem (from KEGG) Pentose and glucuronate interconversions, organism-specific biosystem Pentose and glucuronate[ncbi.nlm.nih.gov] Serum bilirubin and genes controlling bilirubin concentrations as biomarkers for cardiovascular disease.[jama.ama-assn.org]

  • Dubin-Johnson Syndrome

    These results indicate that defects in both conjugated and unconjugated bilirubin metabolism exist in DJS.[ncbi.nlm.nih.gov] We have recently identified the membrane protein mediating the adenosine triphosphate (ATP)-dependent transport of glutathione and glucuronate conjugates as a multidrug-resistance[ncbi.nlm.nih.gov] The conjugation of bilirubin to glucuronate is catalyzed by the enzyme bilirubin-UDP-glucuronosyltransferase (bilirubin-UGT).[themedicalbiochemistrypage.org]

  • Rotor Syndrome

    Bilirubin, a breakdown product of heme, is normally glucuronidated and excreted by the liver into bile.[ncbi.nlm.nih.gov] The conjugation of bilirubin to glucuronate is catalyzed by the enzyme bilirubin-UDP-glucuronosyltransferase (bilirubin-UGT).[themedicalbiochemistrypage.org] UGT1A1 is a liver enzyme that participates in bilirubin processing (it conjugates bilirubin with one or two molecules of glucuronic acid, if you must know).[pathologystudent.com]

  • Crigler-Najjar Syndrome Type 2

    bilirubin (direct bilirubin), will be detected in both type 1 and type 2 disease.[symptoma.com] The conjugation of bilirubin to glucuronate is catalyzed by the enzyme bilirubin-UDP-glucuronosyltransferase (bilirubin-UGT).[themedicalbiochemistrypage.org] […] genetic lesions involving a single complex locus encoding for bilirubin-UDP-glucuronosyltransferase which is involved in the detoxification of bilirubin by conjugation with glucuronic[haematologica.org]

  • Transient Familial Neonatal Hyperbilirubinemia

    […] of bilirubin to bilirubin glucuronides, (iii) excretion of conjugated bilirubin into bile, and (iv) reuptake of conjugated bilirubin by hepatocytes.[nature.com] […] the molecular mechanisms of the three sequential steps of bilirubin elimination: passage of bilirubin from blood into liver cells; conjugation (joining) of bilirubin with glucuronic[acutecaretesting.org] Attachment of glucuronic acid to bilirubin occurs through an ester linkage and, therefore, is called esterification.[emedicine.medscape.com]

  • Jaundice

    bilirubin.[healdove.com] Bilirubin is conjugated with glucuronic acid in the liver. Much of the conjugated bilirubin enters the intestine.[patient.info] In the intestinal lumen during the first week of life, β-glucuronidase may split off glucuronic acid after which bilirubin may be reabsorbed from the intestine.[acutecaretesting.org]

  • Physiological Neonatal Jaundice

    Rubaltelli FF (1993) Bilirubin metabolism in the newborn. Biol Neonate 63: 133–138 PubMed CrossRef Google Scholar 4.[link.springer.com] […] workload of the hepato-enteric circulation Less bacterial (low conversion of bilirubin to urobilinogen by the intestinal flora) Low enzymatic activity in intestine ( UDP glucuron[slideshare.net] Under normal conditions the esterification of propionic carboxyl occurs with the hydroxyl in position 1 glucuronic acid.[spazioinwind.libero.it]

  • Neonatal Jaundice

    This descriptive study compared transcutaneous bilirubin assessment and laboratory serum bilirubin.[ncbi.nlm.nih.gov] This process starts in the spleen where the unconjugated bilirubin binds with albumin and is transported to the liver and conjugated with glucuronic acid.[heftemcast.co.uk] Bilirubin is bound to glucuronic acid (conjugated) in the hepatocyte endoplasmic reticulum in a reaction catalyzed by uridine diphosphoglucuronyltransferase (UDPGT).[emedicine.com]

  • Neonatal Hyperbilirubinemia

    Bilirubin binding population parameters (not prospective studies to determine whether the new bilirubin binding panel components are better predictors of bilirubin neurotoxicity[ncbi.nlm.nih.gov] B  Conjugation of bilirubin with glucuronic acid is catalyzed by UGT1A1, which transfers glucuronic acid from UDP-glucuronic acid to bilirubin GSTs UDPUDPGAGA UDPUDP BB GAGA[slideshare.net] Unconjugated bilirubin binds to albumin in the blood for transport to the liver, where it is taken up by hepatocytes and conjugated with glucuronic acid by the enzyme uridine[merckmanuals.com]

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