Bilirubin Increased: Causes & Reasons

Possible Causes for Bilirubin Increased

Such individuals have decreased hepatic bilirubin UDP-glucuronosyltransferase activity, decreased bilirubin clearance, and increased serum bilirubin concentrations. [ncbi.nlm.nih.gov]

[…] of bilirubin increases. [liver.ca]

It is caused by increased bilirubin production, decreased bilirubin clearance, and increased enterohepatic circulation. [emedicine.com]

Primary Biliary Cirrhosis

Among patients with early disease, bilirubin increased to >2 mg/dL in the anti-NPC(+) patients (26% vs. 5 %, P = .019). [ncbi.nlm.nih.gov]

Usually, the bilirubin does not increase until a late stage of the disease. Your doctor may decide to conduct one or more of the following tests. [gi.org]

Jaundice, a yellowing of the skin and eyes resulting from increased bilirubin in the blood. Collections of cholesterol under the skin. [disability-benefits-help.org]

Progressive Familial Intrahepatic Cholestasis

She presented with jaundice, pruritus, and increased bilirubin levels, together with elevated gamma glutamyl transferase and alkaline phosphatase levels. [ncbi.nlm.nih.gov]

During the hospital admission the direct bilirubin increased to 8.2 mg/dL out of a total of 10.4 mg/dL. [scielo.org.mx]

In PFICs, laboratory abnormalities include increased serum alkaline phosphatase (ALP), variable elevation of bilirubin, decreased/increased gamma-glutamyltransferase (GGT) [dovepress.com]

Congenital Bile Acid Synthesis Defect Type 2

[…] serum bilirubin and decreased serum cholesterol that has material basis in homozygous or compound heterozygous mutation in the HSD3B7 gene on chromosome 16p. [malacards.org]

In detail, hepatic transaminases and conjugated bilirubin concentrations are usually increased in samples obtained from those suffering from congenital bile acid synthesis [symptoma.com]

[…] blood bilirubin levels Prevalence Number of patients identified in a population at a given time Bilirubin Yellow pigment present in bile References [1] Sundaram SS, Bove [ctrs.fr]

Glycogen Storage Disease Type 7

[…] total bilirubin High bili total 0003573 Jaundice Yellow skin Yellowing of the skin [ more ] 0000952 Reduced erythrocyte 2,3-diphosphoglycerate concentration 0030271 Reticulocytosis [rarediseases.info.nih.gov]

Increased immature red blood cells Increased number of immature red blood cells [ more ] 0001923 Variable expressivity 0003828 Showing of 18 | Last updated: 5/1/2019 Making [rarediseases.info.nih.gov]

Consistent with the presence of a haemolytic anaemia, serum bilirubin from affected dogs was increased in most affected dogs (14 ± 8 μmol/l compared to 2 ± 1 μmol/l in normal [doi.org]

Hepatic Veno-Occlusive Disease

Patients may develop jaundice because of the increased bilirubin levels. If VOD is severe, weight gain and bilirubin levels increase at a faster rate. [voice.ons.org]

Symptoms include enlarged liver, increased bilirubin and weight gain due to fluid retention. [drugs.com]

The total bilirubin (TBIL) level gradually increased to 70 mmol/l and the direct bilirubin (DBIL) level gradually increased to 50 mmol/l, both of which were outside the normal [spandidos-publications.com]

Acute Liver Failure

Bilirubin increases to more than 171 mmol/L, prothrombin time (PT) decreases to less than 40%, progressive shrinkage of liver, significant deterioration of liver function, [doi.org]

Having survived severe septic shock and ARDS his condition has stabilised when suddenly his LFTs become deranged with ALT increases to 3402 U/L, AST to 5322 U/L, Bilirubin [intensivecarenetwork.com]

Also, plasma bilirubin levels are elevated and continue to increase as the disease progresses. [symptoma.com]

Paroxysmal Nocturnal Hemoglobinuria

[…] in total bilirubin concentrations (median 3.4 mg/dL; range 2.1-8.1 mg/dL) during chronic eculizumab treatment and normal/or slightly increased serum aminotransferase activities [ncbi.nlm.nih.gov]

The blood chemistry revealed the pattern of hemolytic anemia with moderate thrombocytopenia, increased reticulocyte, slightly elevated serum bilirubin (indirect: 0.9mg%, direct [happycampus.com]

ATP8B1, NR1H4) were performed in eight (five of eight males; mean age 38 years [range 26-68 years]) out of the 174 pts with PNH/-clone at our department due to a persistent increase [ncbi.nlm.nih.gov]

Polycythemia Vera

[…] leukocyte alkaline phosphatase, increased vit.B12 level, decreased folic acid level, elevated alk.phosphatase & conjungated bilirubin, hypercalcemia. [enotes.tripod.com]

Hemoglobinopathy Spurious polycythemia LABORATORY Polycythemia with elevated Hgb, Hct, platelet counts, WBC, uric acid; decreased erythropoietin, bone marrow erythroid hyperplasia, increased [enotes.tripod.com]

Congenital Bile Acid Synthesis Defect Type 4

[…] blood bilirubin levels Prevalence Number of patients identified in a population at a given time Bilirubin Yellow pigment present in bile References [1] Sundaram SS, Bove [ctrs.fr]

Glutamyl Transpeptidase – a liver enzyme Pruritus Itchy skin sensation Cirrhosis Liver condition characterized by tissue reorganisation and cell damage Hyperbilirubinemia Increased [ctrs.fr]

Hardikar Syndrome

It is caused by increased bilirubin production, decreased bilirubin clearance, and increased enterohepatic circulation. [emedicine.medscape.com]

Steroids can also reduce plasma bilirubin levels in Gilbert syndrome, by increasing hepatic uptake and storage of bilirubin. [emedicine.medscape.com]

The binding of bilirubin to these proteins decreases the efflux of bilirubin back into the plasma and, therefore, increases net bilirubin uptake. (See the image below.) [emedicine.medscape.com]

Congenital Dyserythropoietic Anemia Type 4

[…] urinary ALA and porphobilinogen • Normal fecal sample • Increased alkaline phosphate and bilirubin • Clinical features: vomiting, abdominal pain, psychosis, hypertension, [quizlet.com]

Infants suspected or diagnosed with isoimmune hemolytic anemia should have a baseline measurement of bilirubin and then regular measurements to monitor the rate of increase [oncologynurseadvisor.com]

Five cases were reported to have shown a hematological response to this modality, with an increase in hemoglobin levels and reduction in bilirubin levels. 4, 5 More cases [nature.com]

Mitochondrial DNA Depletion Syndrome Type 3 Hepatocerebral

[…] direct bilirubin and prolonged clotting times. [elsevier.es]

[…] spontaneous bacterial peritonitis on admission to the emergency room since she had a waist circumference 7 cm larger than in the first assessment, progressive jaundice, increased [elsevier.es]

Neonatal Jaundice

Neonatal jaundice is caused by increased bilirubin production, decreased bilirubin clearance, or increased enterohepatic circulation. [msdmanuals.com]

Key Points Neonatal jaundice is caused by increased bilirubin production, decreased bilirubin clearance, or increased enterohepatic circulation. [merckmanuals.com]

[…] combined with increased hydrolysis of conjugated bilirubin increase enterohepatic circulation. [msdmanuals.com]

Growth Hormone Deficiency

Successfully reported this slideshow. ... Published on Aug 3, 2016 Growth hormone deficiency states and growth hormone replacement therapy 1. D R A W O F I S O Y E O. I R E G I S T R A R, E N D O C R I N E U N I T D E PA R T M E N T O F I N T E R N A L M E D I C I N E U C H GROWTH HORMONE DEFICIENCY STATES &[…] [slideshare.net]

Reynolds Syndrome

[…] bleeding 0002239 Hyperbilirubinemia High blood bilirubin levels 0002904 Lip telangiectasia 0000214 Palmar telangiectasia 0100869 Raynaud phenomenon 0030880 Scleroderma 0100324 [rarediseases.info.nih.gov]

[…] phosphatase alkaline without a high level of bilirubin suggests an asymptomatic or an early stage of autoimmune liver pathology 19-21, therefore, PBC was overlapping SSc. [scielo.org.co]

[…] risk of kernicterus due to a fractionally greater free bilirubin – such infants should be aggressively managed with phototherapy where the diagnosis is recognised early enough [dovepress.com]

Myeloproliferative Disease

[…] myeloproliferative syndromes see under disorder. Medical dictionary. 2011. Look at other dictionaries: Myeloproliferative disease — Classification and external resources ICD 10 D47.1 ICD 9 205.1 […] Wikipedia Myeloproliferative Neoplasie — Unter dem Begriff der Myeloproliferativen Neoplasien (MPN) (von altgriechisch µυєλός,[…] [medicine.academic.ru]

Disorder of Iron Metabolism

Abstract Background: Dietary iron overload found in sub‐Saharan Africa might be caused by an interaction between dietary iron and an iron‐loading gene. Caucasian people with ferroportin gene mutations have iron overload histologically similar to that found in African patients with iron overload. Ferroportin is also[…] [doi.org]

Crigler-Najjar Syndrome Type 1

Hepatic bilirubin UDP-glucuronosyltransferase deficiency leads to decreased formation of diconjugates with an ensuing increase in the proportion of bilirubin monoconjugates [jci.org]

However, there is an increased proportion of conjugated bilirubin in plasma. [pubmed.ncbi.nlm.nih.gov]

In the bile from patients with Gilbert's syndrome, a striking increase was found in the proportion of bilirubin monoconjugates (48.6±9.8% of total conjugates) relative to [jci.org]

Rotor Syndrome

Increase unconjugated bilirubin Overproduction Impairment of uptake Defect conjugation of bilirubin Increase conjugated bilirubin Decrease excretion into the bile ductile [slideshare.net]

Elevated total bilirubin Gilbert syndrome Gilberts syndrome Gilbert's syndrome Increased bilirubin level Rotor syndrome Total bilirubin, elevated 277.4 Excludes Applies To [icd9data.com]

The latter can also be encountered in young adults with increased unconjugated bilirubin, as a consequence of Rotor syndrome or an enzyme such as bilirubin-UDP-glucuronyltransferase [symptoma.com]

Dubin-Johnson Syndrome

ALA to bilirubin. [ncbi.nlm.nih.gov]

Dubin-Johnson syndrome or high levels of conjugated bilirubin often secondarily increase the level of unconjugated bilirubin. [symptoma.com]

From Wikidata Jump to navigation Jump to search rare, autosomal recessive, benign disorder that causes an isolated increase of conjugated bilirubin in the serum Dubin Johnson [wikidata.org]

Kernicterus

We hypothesized that in this population, as bilirubin increases and causes auditory brainstem dysfunction, respiratory control system may also be adversely affected leading [ncbi.nlm.nih.gov]

It is suggested that mature newborns with previous severe asphyxia are at a slightly increased risk of developing bilirubin encephalopathy over and above the well-known risk [ncbi.nlm.nih.gov]

Among term infants the test indicated an increase in bilirubin binding affinity after the fifth day of life. [ncbi.nlm.nih.gov]

Hereditary Spherocytosis

Tests may include: Blood smear to show abnormally shaped cells (the red blood cells will appear abnormally small and lack the central pallor) Bilirubin level: indirect Bilirubin [medical-labs.net]

Routine chemistry testing  Bilirubin: Increased  Indirect bilirubin  Urine urobilinogen: increased  Methaemalbumin: Increased  LDH: Increased  Haptoglobin: Decreased [pt.slideshare.net]

an infection or other illness can cause an increase in the destruction of red blood cells, resulting in the appearance of acute symptoms, a hemolytic crisis. [medical-labs.net]

Acquired Hemolytic Anemia

In extravascular hemolysis plasma levels of unconjugated bilirubin increase because the hepatocytes cannot process the excess bilirubin. [med-ed.virginia.edu]

[…] haptoglobin decreased - sign of intravascular hemolysis -bilirubin increased Immune-mediated acquired hemolytic anemia AUTOIMMUNE -will have positive DAT -AIHA ore common [brainscape.com]

Jaundice creates problems associated with increased unconjugated bilirubin. [patient.info]

Acquired Spherocytosis

Jaundice creates problems associated with increased unconjugated bilirubin. [patient.info]

Over a long period of time, increased bilirubin can lead to the development of gallstones. [ihtc.org]

CHEMISTRY TESTS The destruction of red blood cells is characterized by increased unconjugated bilirubin, increased lactate dehydrogenase, and decreased haptoglobin levels. [aafp.org]

Traumatic Hemolytic Anemia

In extravascular hemolysis plasma levels of unconjugated bilirubin increase because the hepatocytes cannot process the excess bilirubin. [med-ed.virginia.edu]

Jaundice creates problems associated with increased unconjugated bilirubin. [patient.info]

CHEMISTRY TESTS The destruction of red blood cells is characterized by increased unconjugated bilirubin, increased lactate dehydrogenase, and decreased haptoglobin levels. [aafp.org]

Cholestatic Jaundice

Again you see an increase in unconjugated bilirubin because the liver cells are sick and unable to process the bilirubin. [examrefresh.com]

Normal / increased Increased Conjugated bilirubin Normal Increased Unconjugated bilirubin Normal / increased Increased Normal Urobilinogen Normal / increased Decreased Decreased [en.wikipedia.org]

Pre hepatic shows and increase in unconjugated bilirubin because the bilirubin does not make it to the liver to be processed (conjugated). [examrefresh.com]

Hemolytic Anemia

[…] of intravascular hemolysis Present Confirm hemoglobin breakdown Total bilirubin Indirect (unconjugated) bilirubin Urinary urobilinogen Increased Increased (hepatic conjugation [accessmedicine.mhmedical.com]

In extravascular hemolysis plasma levels of unconjugated bilirubin increase because the hepatocytes cannot process the excess bilirubin. [med-ed.virginia.edu]

Evidence of RBC and Hb breakdown : -Increased unconjugated (Indirect) Bilirubin. -Increased urinary Urobilinogen. -Increased Stool Sterecobilinogen. [slideshare.net]

Cholestasis of Pregnancy

Serum bilirubin increase depends on: Type of disease. [patient.info]

Hemolysis also results in increased levels of bilirubin in the blood. [onlymyhealth.com]

Severe jaundice also increases the risk of bilirubin passing into the brain, which can cause permanent brain damage. [healthline.com]

Toxic Hemolytic Anemia

In extravascular hemolysis plasma levels of unconjugated bilirubin increase because the hepatocytes cannot process the excess bilirubin. [med-ed.virginia.edu]

The direct bilirubin concentration increased to >50 mg/dL (RI, 0–0.5 mg/dL). His platelet count decreased from 247 × 10 3 /μL to 108 × 10 3 /μL (RI, 150–500 × 10 3 /μL). [clinchem.aaccjnls.org]

Bilirubin catabolism causes increased stercobilin in the stool and urobilinogen in the urine and sometimes cholelithiasis. [merckmanuals.com]