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436 Possible Causes for Bilirubin Increased, Easy Bruising, Fatigue

  • Primary Biliary Cirrhosis

    Patients may have a low platelet count because of an enlarged spleen causing easy bruising.[] Among patients with early disease, bilirubin increased to 2 mg/dL in the anti-NPC( ) patients (26% vs. 5 %, P .019).[] This Review article discusses the natural history and the measurement of fatigue in patients with PBC.[]

  • Paroxysmal Nocturnal Hemoglobinuria

    Symptoms Symptoms may include: Abdominal pain Back pain Blood clots, may form in some people Dark urine, comes and goes Easy bruising or bleeding Headache Shortness of breath[] […] in total bilirubin concentrations (median 3.4 mg/dL; range 2.1-8.1 mg/dL) during chronic eculizumab treatment and normal/or slightly increased serum aminotransferase activities[] Functional Assessment of Chronic Illness Therapy‐Fatigue (FACIT‐Fatigue).[]

  • Myeloproliferative Disease

    Most common in chronic myelogenous leukemia and agnogenic myeloid metaplasia Easy bruising, bleeding, and/or symptoms of thrombosis Swollen, painful joint(s) secondary to[] Splenomegaly, hepatomegaly as well as fatigue, malaise or weight loss may appear in advanced stages.[] We ask about general symptoms (anxious mood, depressed mood, fatigue, pain, and stress) regardless of condition. Last updated: January 30, 2019[]

  • Polycythemia Vera

    Some patients with PV will not demonstrate any symptoms at all, but many will experience easy bruising or bleeding with little or no injury.[] […] leukocyte alkaline phosphatase, increased vit.B12 level, decreased folic acid level, elevated alk.phosphatase & conjungated bilirubin, hypercalcemia.[] Regardless of baseline iron status, treatment with ruxolitinib was associated with improvements in concentration problems, cognitive function, dizziness, fatigue, headaches[]

  • Vitamin B12 Deficiency

    The symptoms of B12 deficiency include tiredness, light-headedness, rapid heart rate, easy bruising and bleeding, weight loss, bowel upset and sore tongue.[] The clinical symptoms are weakness, fatigue, shortness of breath and neurologic abnormalities.[] Due to bilirubin being a degradation product of hemoglobin, increased serum concentration is a marker for increased hemolysis.[]

  • Hereditary Spherocytosis

    Tests may include: Blood smear to show abnormally shaped cells (the red blood cells will appear abnormally small and lack the central pallor) Bilirubin level: indirect Bilirubin[] Pediatric patients with lower scores on physical well-being experienced more fatigue.[] Fatigue is associated with intermittent jaundice.[]

  • Biliary Cirrhosis

    Patients may have a low platelet count because of an enlarged spleen causing easy bruising.[] , ascites, or encephalopathy; and (c) death Pre-UDCA era Serum bilirubin increase preceding death UDCA era UDCA therapy  delay rate of histological progression to cirrhosis[] The problem with fatigue is that it is hidden.[]

  • Acute Renal Failure

    bruising, and pale skin (from anemia); ...[] ALP was found to be increased in 70% of cases, which was concordant with the 78% rate reported in the literature. Bilirubin levels were high in almost all cases.[] The patient was admitted with acute kidney failure for 3 times and due to a history of proximal weakness, fatigue, and muscular cramps after physical activities a glycogen-storage[]

  • Liver Cirrhosis

    There may be also easy bruising. There also may be heavy internal bleeding from the food pipe which may be fatal.[] Laboratory analyses from birth through 12 years of age have shown increased S-Bilirubin levels in 11% of the PiZ infants, which normalized within the first half year of life[] In the presented case, the authors describe an obese middle-aged man that presented to the emergency department for persistent oedema, scleral icterus and fatigue.[]

  • Alcoholic Liver Disease

    bruising accumulation of extra fluid in the legs, known as edema.[] A 30-year-old Chinese woman presented with a 4-month history of fatigue, yellowish discoloration of the eyes, and tea-colored urine.[] The presence of ascites, encephalopathy, increased bilirubin, and increased INR were predictive of 30-day mortality in our patients.[]

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