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837 Possible Causes for Bilirubin Increased, Jaundice, Leukopenia

  • Paroxysmal Nocturnal Hemoglobinuria

    Although the severe obstructive jaundice requiring endoscopic therapy following cholecystectomy was complicated, critical intravascular hemolysis and thrombosis were not observed[ncbi.nlm.nih.gov] CBC showed leukopenia (WBC 2.9 x 103 /µL) with neutropenia (segmented neutrophils 48%), macrocytic anemia (Hgb 6.1 g/dL, hematocrit 20%, MCV,113 fL) and thrombocytopenia ([ncbi.nlm.nih.gov] […] in total bilirubin concentrations (median 3.4 mg/dL; range 2.1-8.1 mg/dL) during chronic eculizumab treatment and normal/or slightly increased serum aminotransferase activities[ncbi.nlm.nih.gov]

  • Adult-Onset Still Disease

    A 48-year-old woman was admitted because of spiking high fever, sore throat, and jaundice.[ncbi.nlm.nih.gov] AOSD patients with RHS showed higher frequencies of leukopenia, anemia, thrombocytopenia, hypoalbuminemia, hypofibrinogenemia, hypertriglyceridemia, hyperferritinemia, and[ncbi.nlm.nih.gov] The next day, the patient developed jaundice.[tropicalgastro.com]

  • Ketoconazole

    The initial presentation of the disease was of a typical acute hepatitis, characterized by nausea, anorexia, fatigue, and jaundice that developed during the administration[ncbi.nlm.nih.gov] Hematologic: thrombocytopenia, hemolytic anemia, leukopenia (with oral administration). Hepatic: fatal hepatotoxicity (with oral administration).[glowm.com] One month after discontinuation of ketoconazole, the liver enzyme concentrations decreased; however, over the next five months, liver enzymes and bilirubin increased.[ncbi.nlm.nih.gov]

  • Splenorenal Shunt

    It is manifested by jaundice and signs of portal hypertension and carries a mortality rate approaching 50%.[ncbi.nlm.nih.gov] In the follow-up course for PH from 1987 to 2006, 15 patients who developed severe thrombocytopenia (platelet count 50 x 10(3)/mm(3)) and/or leukopenia (WBC count 3000/mm([ncbi.nlm.nih.gov] The values of indirect serum bilirubin increased in 92.3% of the patients.[ncbi.nlm.nih.gov]

  • Plasmodium Falciparum Malaria

    In severe cases, it can cause jaundice, seizures, coma, or death.[ncbi.nlm.nih.gov] Fever (100%), splenomegaly (86.7%), hepatomegaly (26.7%), leukopenia (13.3%), thrombocytopenia (80%), elevated liver function tests (40%), and increased serum creatinine levels[ncbi.nlm.nih.gov] bilirubin.[ncbi.nlm.nih.gov]

  • Sulfisoxazole

    LZX-A (neferine), QTJ (sinomenine), YHS (tetrahydropalmitine) and SQZG (notoginsenoside R1) to displace the highly bound bilirubin from albumin binding sites in plasma from jaundiced[ncbi.nlm.nih.gov] Hematologic: Acute hemolytic anemia (especially in patients with G6PD deficiency), aplastic anemia , methemoglobinemia, agranulocytosis , thrombocytopenia, leukopenia, eosinophilia[robholland.com] There was a significant negative correlation between conjugated and indirect bilirubin, while total bilirubin increased in dogs after oral and intravenous administration of[ncbi.nlm.nih.gov]

  • Netilmicin

    Desai TK, Tsang TK "Aminoglycoside nephrotoxicity in obstructive jaundice." Am J Med 85 (1988): 47-50 11.[drugs.com] Hematologic: Increases in ALT, AST, alkaline phosphatase, bilirubin; anemia, eosinophilia, neutropenia, thrombocytopenia, thrombocytosis, agranulocytosis , leukopenia, leukemoid[robholland.com] Increased blood sugar; increased alkaline phosphatase; increased liver enzymes, bilirubin; increased potassium; other abnormal LFTs; decreased haemoglobin, WBCs and platelets[sastimedicine.com]

  • Stem Cell Transplant

    […] for chronic graft versus host disease that initially started 50 days posttransplant, she developed hepatic dysfunction during the steroid taper on day 531, as evidenced by jaundice[ncbi.nlm.nih.gov] When comparing the conditioning and mobilization phases, there was an increased number days of leukopenia (white blood cells 1.0 109/L), lymphocytopenia (lymphocytes 0.5 109[ncbi.nlm.nih.gov] It is clinically characterized by tender hepatomegaly, jaundice, weight gain and ascites.[ncbi.nlm.nih.gov]

  • Jaundice

    "Can sunlight replace phototherapy units in the treatment of neonatal jaundice? An in vitro study".[en.wikipedia.org] A 48-year-old African-American male subject presented with progressive fatigue, jaundice, and new-onset leukopenia 12 weeks after undergoing bilateral lung transplantation[ncbi.nlm.nih.gov] Bilirubin levels increase over the first several days and then fall slowly. Phototherapy is usually needed for a few days, but occasionally for more than a week.[unitypoint.org]

  • Chlorpromazine

    The jaundice resolved very slowly after ursodeoxycholic acid therapy.[ncbi.nlm.nih.gov] […] cause anticholinergic effects; use caution in patients with paralytic ileus, gastrointestinal motility, urinary retention, xerostomia, or visual problems Agranulocytosis, leukopenia[reference.medscape.com] Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, bilirubin : increased levels Granulocytes, hematocrit, hemoglobin, platelets, white blood cells[medical-dictionary.thefreedictionary.com]

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