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25 Possible Causes for Bimodal Age of Onset, Hyperreflexia, Spasticity - Hyperreflexia

  • Autosomal Dominant Spastic Paraplegia Type 31

    24, Autosomal Recessive Symptoms via clinical synopsis from OMIM: 57 Neurologic Central Nervous System: spasticity hyperreflexia clonus difficulty standing walking on tiptoes[malacards.org] age of onset of either childhood or adulthood ( 30 years).[orpha.net] Neurologic examination revealed hyperreflexia and spasticity in the lower extremities, weakness of hip flexion and ankle dorsiflexion, extensor plantar response, diminished[neurology.org]

  • Autosomal Dominant Spastic Paraplegia Type 10

    ) is a rare type of hereditary spastic paraplegia that can present as either a pure form of spastic paraplegia with lower limb spasticity, hyperreflexia and extensor plantar[orpha.net] […] distribution of age of symptom onset: during the 2 first decades and then in the third decade. [3,12,17] However some patients have been reported to present their first symptoms[journals.lww.com] […] paraplegia type 10 Disease definition A rare type of hereditary spastic paraplegia that can present as either a pure form of spastic paraplegia with lower limb spasticity, hyperreflexia[orpha.net]

  • Autosomal Dominant Spastic Paraplegia Type 8

    24, Autosomal Recessive Symptoms via clinical synopsis from OMIM: 57 Neurologic Central Nervous System: spasticity hyperreflexia clonus difficulty standing walking on tiptoes[malacards.org] The mean age of onset is around 40 years with a bimodal distribution, one in the 3 rd and one in the 6 th decade.[neuroweb.us] People with this condition may also have hyperreflexia, decreased ability to feel vibrations, muscular atrophy and decreased bladder control.[ivami.com]

  • Autosomal Recessive Spastic Paraplegia Type 54

    All the affecteds suffered intellectual disability and/or developmental delay, spastic paraplegia, hyperreflexia and foot contractures.[cags.org.ae] In our cohort, the age of onset follows a bimodal distribution, with most juvenile forms (SPG 3a, 10, 11, 31) manifesting within the fifth year of life, and a second peak[journals.plos.org] The pure form presents isolated pyramidal signs such as spasticity, hyperreflexia, Babinski sign, and motor deficits, which can be associated with sphincter disorder and deep[neurohic.com]

  • Autosomal Dominant Spastic Paraplegia Type 19

    […] paraplegia 8 is a neurologic disorder characterized by severe lower limb spasticity and weakness.[cags.org.ae] The mean age of onset is around 40 years with a bimodal distribution, one in the 3 rd and one in the 6 th decade.[neuroweb.us] People with spastic paraplegia type 31 can also experience progressive muscle wasting (amyotrophy) in the lower limbs, exaggerated reflexes (hyperreflexia), a decreased ability[ghr.nlm.nih.gov]

  • Pure Hereditary Spastic Paraplegia

    […] and weakness, hyperreflexia, ankle … View Full Text AAN Members: Sign in with your AAN member credentials (e-mail or 6-digit Member ID number) Non-AAN Member subscribers:[neurology.org] In our cohort, the age of onset follows a bimodal distribution, with most juvenile forms (SPG 3a, 10, 11, 31) manifesting within the fifth year of life, and a second peak[journals.plos.org] People with this condition can also experience exaggerated reflexes (hyperreflexia), ankle spasms, high-arched feet (pes cavus), and reduced bladder control.[icdlist.com]

  • Autosomal Dominant Spastic Paraplegia Type 42

    The pure form presents isolated pyramidal signs such as spasticity, hyperreflexia, Babinski sign, and motor deficits, which can be associated with sphincter disorder and deep[neurohic.com] […] distribution of age of symptom onset: during the 2 first decades and then in the third decade. [3,12,17] However some patients have been reported to present their first symptoms[journals.lww.com] Hereditary spastic paraplegias (HSP) comprise a genetically and clinically heterogeneous group of neurodegenerative disorders characterised by progressive spasticity and hyperreflexia[onlinelibrary.wiley.com]

  • Autosomal Dominant Spastic Paraplegia Type 33

    The pure form presents isolated pyramidal signs such as spasticity, hyperreflexia, Babinski sign, and motor deficits, which can be associated with sphincter disorder and deep[neurohic.com] Spasticity showed a bimodal distribution, with both grades 1 (minimum) and 4 (maximum). Hand grip strength showed a moderate inverse correlation with age.[doctiktak.com] […] spastic paraplegia type 17 Disease definition A complex hereditary spastic paraplegia characterized by progressive spastic paraplegia, upper and lower limb muscle atrophy, hyperreflexia[orpha.net]

  • Spastic Paraplegia - Ataxia - Mental Retardation

    These sibs did not have overt spasticity, but had some pyramidal signs, such as hyperreflexia.[findzebra.com] The mean age of onset is around 40 years with a bimodal distribution, one in the 3 rd and one in the 6 th decade.[neuroweb.us] Hereditary spastic paraplegias (HSP) comprise a genetically and clinically heterogeneous group of neurodegenerative disorders characterized by progressive spasticity and hyperreflexia[monarchinitiative.org]

  • Infantile Choroidocerebral Calcification Syndrome

    Basal ganglia calcification Toe walking Spastic gait Paraplegia Unsteady gait Peripheral axonal neuropathy Spastic paraplegia Babinski sign Hypoplasia of the corpus callosum[mendelian.co] […] peak of age development: an early-onset (congenital) form affecting 60% of patients and a later-onset form during childhood and adolescence (40% of cases). 23 Glaucoma in[dovepress.com] 60 33 Very frequent (99-80%) HP:0001250 2 intellectual disability, severe 60 33 Very frequent (99-80%) HP:0010864 3 strabismus 60 33 Very frequent (99-80%) HP:0000486 4 hyperreflexia[malacards.org]

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