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1,555 Possible Causes for binding, histone

  • Viral Lower Respiratory Infection

    However, this influenza virus directly inhibits pulmonary epithelial sodium transport, which removes water from the alveolar space by osmosis: Viral hemagglutinin binds to[nejm.org] Conserved herpesvirus kinases target the DNA damage response pathway and TIP60 histone acetyltransferase to promote virus replication.[ijcancerprevention.com] There are vitamin D receptors found on cells in the immune system and the respiratory tract, and vitamin D can bind to these receptors 9 .[vitamindcouncil.org]

  • Drug-induced Fever

    Researchers believe that some drugs can bind directly to a certain type of immune system white blood cell called a T cell.[mayoclinic.org] Thus they are called anti-histone antibodies. Anti-histone antibodies may be seen in both systemic lupus erythematosus and drug-induced lupus.[clinicaladvisor.com] These hapten-antibody complexes bind complements and result in different hypersensitivity reactions of rifampicin. [5] Ethambutol also can cause flu-like illness. [6] Though[lungindia.com]

  • Osteoporosis

    CA1 and S100P may regulate the process of MIO by modulation of calcification and dysregulation of calcium binding.[ncbi.nlm.nih.gov] Histone modifications can regulate gene expression by influencing interactions between DNA and histones, for example by acetylation and methylation of conserved lysine residues[doi.org] Homocysteine (HCY) has been found to accumulate in bone by collagen binding.[ncbi.nlm.nih.gov]

  • Dementia

    Because FDG does not bind to pathologic proteins, FDG-PET requires that the reader recognize characteristic patterns of glucose hypometabolism to identify pathology.[ncbi.nlm.nih.gov] Fischer , Histone Deacetylases as Therapeutic Targets in Neurodegenerative Diseases , Medical Epigenetics , 10.1016/B978-0-12-803239-8.00003-X , (33-45) , (2016) .[doi.org] RAGE Inhibitor Amyloid is also known to bind to receptors for advanced glycated endproducts (RAGE) on the surface of cells and at the blood-brain barrier; this binding may[doi.org]

  • Rubinstein-Taybi Syndrome

    The known genetic causes are point mutations or deletions of the cAMP-response element binding protein-BP (CREBBP) (50-60% of the cases) and of the homologous gene E1A-binding[ncbi.nlm.nih.gov] […] acetylation, affecting primarily histone H2B and histone H2A.[ncbi.nlm.nih.gov] Mutations in the gene encoding the cAMP response element-binding protein (CREB, also known as CREBBP or CBP) on chromosome 16p13.3 have been identified.[ncbi.nlm.nih.gov]

  • Adrenal Insufficiency

    Abstract Cortisol is a hydrophobic molecule that is largely bound to corticosteroid-binding globulin (CBG) in the circulation.[ncbi.nlm.nih.gov] Tõnis Org, Ana Rebane, Kai Kisand, Martti Laan, Uku Haljasorg, Reidar Andreson and Pärt Peterson , AIRE activated tissue specific genes have histone modifications associated[doi.org] In patients with low and near-normal cortisol-binding proteins, a serum cortisol of 1.8 μg/dL, although further studies are needed to define a normal range in critically ill[ncbi.nlm.nih.gov]

  • Valproic Acid

    Docking simulations indicated that four groups of binding structures were involved in the binding of VPA-G, panipenem, and meropenem to APEH, but only one or two binding structures[ncbi.nlm.nih.gov] Acetylation of histon H3 was detected with ELISA assay.[ncbi.nlm.nih.gov] PURPOSE: The aim was to study the biological and molecular effects of the histone deacetylase (HDAC) inhibitor, valproic acid, in patients with solid tumor malignancies.[ncbi.nlm.nih.gov]

  • Drug-induced Lupus Erythematosus

    Chlorpromazine did not cause apoptosis by inhibition of cytokine binding or blockade of early intracellular signaling.[ncbi.nlm.nih.gov] Furthermore, Anti-Histone antibodies can also be positive in drug induced lupus. Anti-Histone antibodies are positive in up to 95% of patients with drug induced lupus.[en.wikipedia.org] T1/2 was not significantly associated with Clq or DNA binding levels in symptomatic or asymptomatic patients.[ncbi.nlm.nih.gov]

  • Rett Syndrome

    Abstract Methyl-CpG binding protein 2 (MeCP2) binds to methylated cytosine in CpG island through its methyl-CpG binding domain (MBD).[ncbi.nlm.nih.gov] Acomplex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression.[doi.org] These improvements were accompanied by increased binding of MeCP2 T158M to DNA.[ncbi.nlm.nih.gov]

  • Tuberculosis

    ., 2013 Protein synthesis inhibitor Aminoglycosides Streptomycin Bind to 30S subunit of ribosome MDR, XDR High Mutation in rpsl Honort and Cole, 1994 Amikacin Bind to 30S[ncbi.nlm.nih.gov] Comparative gene expression profiling revealed that many of the Mtb genes involved in protein synthesis, ESX-3/secretion, iron metabolism and histone-like proteins were up-regulated[ncbi.nlm.nih.gov] Acquired resistance to linezolid was observed in the isolates from four patients; mutations in the linezolid-binding site of the 23S ribosomal RNA (rRNA) developed in two[dx.doi.org]

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