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5,031 Possible Causes for binding, peroxisome, signal 2, targeting

  • Rhizomelic Chondrodysplasia Punctata

    These antibodies inhibit a high-affinity calcium-binding protein of endoplasmic reticulum, calreticulin.[] At the cellular level, RCDP is unique in that the biogenesis of most peroxisomal proteins is normal, but a specific subset of at least four, and maybe more, peroxisomal matrix[] […] two peroxisomal targeting sequences (PTS1 and PTS2).[] Substances PEX7 protein, human Peroxisomal Targeting Signal 2 Receptor Receptors, Cytoplasmic and Nuclear Acetyl-CoA C-Acyltransferase Supplementary concept Rhizomelic chondrodysplasia[]

  • Osteoporosis

    CA1 and S100P may regulate the process of MIO by modulation of calcification and dysregulation of calcium binding.[] Differential activation of peroxisome proliferator-activated receptor-γ by troglitazone and rosiglitazone . Diabetes 2000 ; 49: 539 – 47 .[] In the PMO-KY treatment, NCOA3, TCF4, DUSP6, PELI2, and STX7 might be the potential therapeutic targets of LDP.[] , nitrous oxide, and leukotrienes; collagen abnormalities; and leptin-related adrenergic signaling. 2 Osteoporotic fractures represent the clinical significance of these derangements[]

  • Troglitazone

    […] toxicoproteomics, we demonstrated a powerful systems approach in identifying the collapse of specific fragile nodes and activation of crucial proteome reconfiguration regulators when targeted[] Finally, peroxisome proliferator activated receptor gamma (PPAR(gamma)) binding activity was measured to check the binding affinities of both TGZ and TSN.[] Abstract Agonist ligands for the nuclear receptor peroxisome proliferator-activated receptor-gamma have been shown to induce terminal differentiation of normal preadipocytes[] In search of upstream mediators of toxicity, we hypothesized that troglitazone-induced increased mitochondrial generation of superoxide might activate the thioredoxin-2 (Trx2[]

  • Clofibrate

    Spin-labeled clofibrate binding to LDL is enhanced when the temperature increases above 25 degrees C. The binding to HDL and VLDL is less temperature-sensitive.[] Liver biopsies were taken after 2, 4, and 7 yr, to follow the peroxisomal response.[] ): D00279 JP Efficacy Antihyperlipidemic, Triglyceride synthesis inhibitor, Peroxisome proliferator-activated receptor (PPAR) alpha agonist Comment Clofibrate derivative Target[] , Molecules , 10.3390/molecules24020264 , 24 , 2 , (264) , (2019) .[]

  • Influenza

    To determine if egg-adapted H1N1 vaccines commonly elicit antibodies targeting the egg-adapted RBS of HA, we completed hemagglutinin-inhibition assays with A/California/7[] MDCK cell binding assays The cell binding assays were performed in 96-well plates as previously described [ 46 ].[] 1 (NLS1) Add BLAST 16 Motif i 184 – 247 Nuclear localization signal 2 (NLS2) Add BLAST 64 Sequence similarities i Phylogenomic databases Family and domain databases Sequence[] Here we use a simulation model of influenza transmission in Southeast Asia to evaluate the potential effectiveness of targeted mass prophylactic use of antiviral drugs as[]

    Missing: peroxisome
  • Refsum Disease

    […] the enzyme defective in Refsum disease is targetted to peroxisomes by a PTS2.[] […] of 2OG binds to the Fe(II) in a bidentate manner.[] […] and hence to a generalized loss of peroxisomal functions.[] 2.[]

  • Peroxisomal Disease

    These findings may be of relevance for patient management while unveiling novel therapeutic targets for X-ALD.[] […] plasmalogens) glyceryl ether lipid levels were measured in post-mortem brain and/or liver biopsies from 7 patients with ultrastructural and biochemical evidence of a defect in peroxisomal[] signal-2 (PTS-2)-mediated protein transport processes into peroxisomes are normal in this patient.[] Inherited Metabolic Epilepsies opens with a section on general principles for diagnosis and targeted intervention including screening protocols, laboratory testing, neuroimaging[]

  • Insulin-Like Growth Factor I

    IGF-IR has been targeted in efforts directed toward drug development for cancer, employing both small-molecule and monoclonal antibody approaches.[] IGF activity is modulated by a family of high-affinity IGF-binding proteins, and IGFBP-6 is distinctive because of its marked binding preference for IGF-II over IGF-I.[] SIGNOR i P05019 Names & Taxonomy i Organism-specific databases Subcellular location i Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome[] These data provide evidence that different antidepressants induce LPA1 activation, leading to receptor tyrosine kinase transactivation, stimulation of ERK1/2 signaling and[]

  • Rhizomelic Chondrodysplasia Punctata Type 1

    […] defect in RCDP fibroblasts, whereas two alleles found only in patients with mild disease complemented the targeting defect upon overexpression.[] Fig. 1 Binding manner of PTS2 determined by crystal structure (a) Crystal structures of Pex7, Pex21, and PTS2-MBP (maltose binding protein).[] The inability of PEX7 protein to transport PTS2 containing proteins including peroxisomal 3-ketoacyl-CoA thiolase and PTS2-EGFP protein to the surface of the peroxisomes showed[] Abstract Peroxisomes are involved in various metabolic reactions.[]

  • Rhizomelic Chondrodysplasia Punctata Type 2

    Fig. 1 Binding manner of PTS2 determined by crystal structure (a) Crystal structures of Pex7, Pex21, and PTS2-MBP (maltose binding protein).[] […] into peroxisomes.[] […] rhizomelic chondrodysplasia punctata [MIM*215100] autosomal recessively inherited lethal chondrodysplasia caused by mutation in the PEX7 gene encoding the peroxisomal type 2 targeting[] The majority of patients affected by this disease carry mutations in the PEX7 gene (6q21-q22.2) encoding the peroxisomal targeting signal 2 receptor which plays an important[]