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370 Possible Causes for biogenesis, spindle

  • Perineurioma

    Histologically, they were composed of intimately admixed plump spindle cells and elongated slender spindle cells forming storiform, lamellar or fascicular architecture.[ncbi.nlm.nih.gov] Primary antisera used were directed against EMA (Dako M613, USA, 10/500), S100 protein (Dako L1845, USA, pred), neurofilament protein (Biogenesis 6670-0154, USA), neurospecific[scielo.isciii.es] All tumors were characterized by a proliferation of cytologically bland, mitotically inactive spindled cells with round, ovoid or spindled nuclei, embedded in a variably collagenous[ncbi.nlm.nih.gov]

  • Zellweger Syndrome

    ., the centriole or the mitotic spindle) and is partitioned along with the division and segregation of the underlying structure.[physrev.physiology.org] Peroxisome biogenesis disorders are inherited in an autosomal recessive manner and result from mutations in any of at least 12 PEX genes that encode peroxins.[ncbi.nlm.nih.gov] Abstract Zellweger syndrome (ZS) is the severest variety of peroxisomal biogenesis disorder (PBD). This is a fatal hereditary, autosomal recessive disorder.[ncbi.nlm.nih.gov]

  • Autosomal Recessive Primary Microcephaly

    CONCLUSION: We propose that a disruption of centrosome integrity and/or spindle organization may play an important role in the development of microcephaly in MCPH2.[ncbi.nlm.nih.gov] Plk4-induced centriole biogenesis in human cells.[ncbi.nlm.nih.gov] Whereas microcephalin is a component of the DNA damage response and a repressor of telomerase function, ASPM is required for the proper formation of a central mitotic spindle[ncbi.nlm.nih.gov]

  • Heimler Syndrome

    HEXB Sandhoff disease HGSNAT Mucopolysaccharidosis (Sanfilippo syndrome), Retinitis pigmentosa HPD Hawksinuria, Tyrosinemia HRAS Congenital myopathy with excess of muscle spindles[genda.com.ar] Peroxisome biogenesis disorders are generally considered to be severe multisystem disorders, often with a progressive component.[ommbidblog.com] Loss-of-function mutations in both genes are known causes of a spectrum of autosomal-recessive peroxisome-biogenesis disorders (PBDs), including Zellweger syndrome.[ncbi.nlm.nih.gov]

  • Rhizomelic Chondrodysplasia Punctata Type 2

    […] lamina cribrosa Bouw van het reukepitheel neuroepitheliale cellen, olfactoire cilia, nervus olfactorius, nI Seeing, Hearing and Smelling the World Sensory Receptors II Muscle Spindle[catsclem.nl] Factor biogenesis peroxisomal 7 also carries fitanoil-CoA hydroxylase enzyme encoded by the gene PHYH.[ivami.com] […] and/or functioning of the peroxisomes and are referred to as peroxisome biogenesis disorders, PBDs.[themedicalbiochemistrypage.org]

  • Epithelioid Cell Sarcoma

    FU-EPS-1 cells were round, polygonal or spindle shaped with an abundant cytoplasm, and have been maintained continuously in vitro for over 100 passages during more than 15[ncbi.nlm.nih.gov] CNoBs depend on RNA polymerase I activity, indicating a role in ribosome biogenesis [ 7 ].[doi.org] Nucleophosmin Nucleophosmin is a multifunctional protein that regulates ribosome biogenesis, RNA transcription, histone assembly and DNA repair [ 78 ].[doi.org]

  • Autosomal Recessive Primary Microcephaly 12

    Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy. Nat. Genet. 46, 1283-1292.[cmmc-uni-koeln.de] PMID 17090670 The microcephaly ASPM gene is expressed in proliferating tissues and encodes for a mitotic spindle protein.[atlasgeneticsoncology.org] Deletion Mutation in ASPM Gene in an Iranian Family with Autosomal Recessive Primary Microcephaly. ( 24665293 ) Akbariazar E....Kahrizi K. 2013 11 Abnormal centrosome and spindle[malacards.org]

  • Rhizomelic Chondrodysplasia Punctata Type 3

    […] lamina cribrosa Bouw van het reukepitheel neuroepitheliale cellen, olfactoire cilia, nervus olfactorius, nI Seeing, Hearing and Smelling the World Sensory Receptors II Muscle Spindle[catsclem.nl] Factor biogenesis peroxisomal 7 also carries fitanoil-CoA hydroxylase enzyme encoded by the gene PHYH.[ivami.com] […] and/or functioning of the peroxisomes and are referred to as peroxisome biogenesis disorders, PBDs.[themedicalbiochemistrypage.org]

  • Malignant Fibrous Histiocytoma

    Previous studies have demonstrated that decreased mitochondrial biogenesis is associated with cancer progression.[ncbi.nlm.nih.gov] Occasionally, spindle cells or osteoclast-like giant cells can be observed. Herein, we present a case of epithelioid hemangioendothelioma in a 38 year-old Chinese male.[ncbi.nlm.nih.gov] HO-1 is essential for tetrahydroxystilbene glucoside mediated mitochondrial biogenesis and anti-inflammation process in LPS-treated RAW264.7 macrophages.[link.springer.com]

  • Vinblastine

    -7 cells. 5HPP-33 (5 μM) reduced the dynamicity of microtubules by 62% compared to the control. 5HPP-33 treatment reduced the distance between the two poles of a bipolar spindle[ncbi.nlm.nih.gov] "Biogenesis of Strychnos, Aspidosperma, and Iboga alkaloids. The structure and reactions of preakuammicine." J Am Chem Soc 91(21);5874-6.[metacyc.org] Treatment of ansamitocin P3 activated spindle checkpoint surveillance proteins, Mad2 and BubR1 and blocked the cells in mitotic phase of the cell cycle.[ncbi.nlm.nih.gov]

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