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182 Possible Causes for Blast Cells Present

  • Philadelphia Chromosome Positive Chronic Myeloid Leukemia

    Pediatric chronic myeloid leukemia with B - cell lymphoid blast crisis at presentation. Blood Res 2013;48:151 -2. 3. Calabretta B, Perrotti D.[] The World Health Organization (WHO) has defined the criteria for each in accordance with the percentage of blast cells and other important values.[] The majority of patients are diagnosed in the chronic phase and may be either asymptomatic (diagnosed through a routine white blood cell count) or present with fatigue, anaemia[]

  • Chronic Myelomonocytic Leukemia

    Bone Marrow flow cytometry: 78% mature granulocytes, 2% lymphocytes, 10% monocytes, 7% erythroid precursors and 3% blasts. 1% CD19-positive B cells present, 1% CD3-positive[] Weak expressions of CD36 and CD64 were also present, demonstrating that these cells lean towards the monocytic/dendritic lineage.[] Bone marrow: Bone marrow smears show a hypercellular tissue in which blast cell percentage (myeloblasts and monoblasts) remains lower than 20%.[]

  • Chronic Eosinophilic Leukemia

    The bone marrow exhibited 45% to 55% eosinophilic hyperplasia and 30% of myeloid blast cells (panel C; blue arrows show blast cells).[] Presently, an unexplained chronic persistent eosinophilia with a demonstrable cytogenetic abnormality or an increase in blast cells is considered as eosinophilic leukemia[] Red blood cells and platelets were normal and there were no circulating blast cells.[]

  • Aggressive Systemic Mastocytosis

    Aggressive systemic mastocytosis (ASM) is a rare form of systemic mastocytosis. Affected individuals may present with symptoms due to organopathies caused by mast cell infiltration, bone marrow failure and subsequent cytopenias, and symptoms of mast cell activation - clinical presentations are heterogeneous.[…][]

  • Anemia

    cells Lead poisoning Risk factors include young age, living in a home built before 1970 or in areas where soil is contaminated, and pica (as in iron deficiency) In addition[] , nonspecific bone pain, gum swelling, or rash Normocytic anemia with decreased reticulocyte count; leukopenia, leukocytosis, or thrombocytopenia; peripheral smear shows blast[] Usually spontaneous, but rates are increased in patients with prior radiation exposure or chemotherapy Anemia causes pallor, fatigue, and dyspnea; patients with leukemia may present[]

  • Thrombocytopenia

    High white blood cell count or blasts may be present in acute or chronic leukemia. Step 2: Review peripheral smear.[] Presence of blasts on a blood film Presence of blast cells and/or any dysplastic changes is likely to be the first presentation of a haematological malignancy. 27 Evidence[]

  • Infectious Mononucleosis

    cells/necrosis are presented in the histological sample.[] Priming of naïve T cells by antigen-presenting cells occurs in parallel. Normally, these blasting B cells are destroyed by cytotoxic T lymphocytes.[] Histology of Pfeiffer’s glandular fever Typical in infectious mononucleosis is the picture of polymorphic hyperplasia of the pulp: propagation in lymph nodes and fast-growth of blast[]

  • Refractory Anemia with Excess Blasts in Transformation

    The blast cell present in the BM are usually CD34 and express myeloid markers (i.e. CD33 and/or CD13).[] (Outcomes/Resolutions) The severity of Refractory Anemia with Excess Blasts depends on the degree to which blast cell levels are elevated, and if Auer rods are present.[] There can also be abnormal platelets (large, giant or hypogranular) and red cell anisopoikilocytosis. Blasts are commonly present.[]

  • Non-Hodgkin Lymphoma

    The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts).[] According to the type of blasts present, acute leukemias are classified as acute myeloid leukemia (aml) and precursor lymphoblastic or acute lymphoblastic leukemia (all).[] A malignant (clonal) hematologic disorder, involving hematopoietic stem cells and characterized by the presence of primitive or atypical myeloid or lymphoid cells in the bone[]

  • Tumor Lysis Syndrome

    Notable laboratory findings included white blood cell count of 479   10(3) cells/µL (4.00   10(3) cells/µL-10.80   10(3) cells/µL) with 95% lymphocytes (20%-50%) and 5% blasts[] However, in contrast to previous reports in ALL or acute myeloid leukemia, our patient did not have blasts noted on periphereal blood smear and her white blood cell count[] (zero) present in the differential, serum potassium 9.8 mM/L (3.4 mM/L-5.0 mM/L), uric acid of 11.8 mg/dL (3.5 mg/dL-8.0 mg/dL), serum creatinine 1.47 mg/dL (0.60 mg/dL-1.30[]

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