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77 Possible Causes for Blast Cells Present, Peripheral Blood Smear Abnormal

  • Chronic Myelomonocytic Leukemia

    Peripheral blood smear for CMML showing abnormal cells. Chronic myelomonocytic leukemia (CMML) is an aggressive cancer of the blood that is resistant to treatment.[healthsciences.utah.edu] Bone Marrow flow cytometry: 78% mature granulocytes, 2% lymphocytes, 10% monocytes, 7% erythroid precursors and 3% blasts. 1% CD19-positive B cells present, 1% CD3-positive[omicsgroup.org] In addition, morphologic evaluation of the peripheral blood smear and T-cell gene rearrangement studies by polymerase chain reaction (PCR) were performed.[ncbi.nlm.nih.gov]

  • Chronic Eosinophilic Leukemia

    The bone marrow exhibited 45% to 55% eosinophilic hyperplasia and 30% of myeloid blast cells (panel C; blue arrows show blast cells).[bloodjournal.org] Presently, an unexplained chronic persistent eosinophilia with a demonstrable cytogenetic abnormality or an increase in blast cells is considered as eosinophilic leukemia[article.sciencepublishinggroup.com] The presentation with peripheral eosinophilia, absolute eosinophil count 5000/mm 3 , bone marrow showing increased eosinophilic precursors and infiltration by atypical cells[e-ijd.org]

  • Philadelphia Chromosome Positive Chronic Myeloid Leukemia

    Pediatric chronic myeloid leukemia with B - cell lymphoid blast crisis at presentation. Blood Res 2013;48:151 -2. 3. Calabretta B, Perrotti D.[ajmhs.org] The World Health Organization (WHO) has defined the criteria for each in accordance with the percentage of blast cells and other important values.[symptoma.com] The majority of patients are diagnosed in the chronic phase and may be either asymptomatic (diagnosed through a routine white blood cell count) or present with fatigue, anaemia[orpha.net]

  • T-cell Acute Lymphoblastic Leukemia

    Clinically, T-ALL patients present with diffuse infiltration of the bone marrow by immature T-cell blasts high blood cell counts, mediastinal involvement, and diffusion to[ncbi.nlm.nih.gov] Published: 5 September 2017 T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease caused by the malignant transformation of immature progenitors primed towards T-cell[mdpi.com] However, in contrast to previous reports in ALL or acute myeloid leukemia, our patient did not have blasts noted on periphereal blood smear and her white blood cell count[ncbi.nlm.nih.gov]

  • B-Precursor Acute Lymphoblastic Leukemia

    CD1d leukemic blasts were able to present alpha-GalCer via CD1d to cytotoxic CD1d-restricted T cells, which induced apoptosis of ALL cells that was inhibited by mAb to CD1d[ncbi.nlm.nih.gov] In the leukemic form, by definition, the bone marrow must contain at least 20% blast cells.[mjhid.org] At diagnosis, there is essentially complete replacement of normal hematopoiesis with blast cells and there are no differentiating morphologic features between patients with[journals.plos.org]

  • Refractory Anemia with Excess Blasts

    Peripheral blood smear The peripheral blood frequently shows abnormal cytoplasmic granularity and nuclear segmentation of the neutrophils.[imagebank.hematology.org] The blast cell present in the BM are usually CD34 and express myeloid markers (i.e. CD33 and/or CD13).[atlasgeneticsoncology.org] The peripheral blood smear can show macrocytosis of the red cells and hypo-granular neutrophils.[businessandleadership.com]

  • Thrombocytopenia

    Peripheral blood smear shows abnormal erythrocyte size and shape as well as paucity of platelets.[orpha.net] High white blood cell count or blasts may be present in acute or chronic leukemia. Step 2: Review peripheral smear.[antimicrobe.org] Blasts are frequently present on the blood smear.[oncologynurseadvisor.com]

  • Refractory Anemia with Excess Blasts in Transformation

    Peripheral blood smear The peripheral blood frequently shows abnormal cytoplasmic granularity and nuclear segmentation of the neutrophils.[imagebank.hematology.org] The blast cell present in the BM are usually CD34 and express myeloid markers (i.e. CD33 and/or CD13).[atlasgeneticsoncology.org] Leukemia that is characterized by the presence of abnormal white blood cells in the peripheral blood but in which the total number of white blood cells is normal.[quizlet.com]

  • Adult T-Cell Leukemia - Lymphoma

    […] count 5% abnormal lymphocytes Peripheral blood smear with “flower” cells Serology antibodies to HTLV-1 Hypercalcemia Flow cytometry or immunohistochemistry CD4 , CD25 , CD52[medbullets.com] (in Hodgkin lymphoma like cases with expansion of EBV B cells), blast-like cells, giant cells may also be present Cutaneous infiltrates are dermal (mainly perivascular but[pathologyoutlines.com] […] lymphocytes on peripheral blood smear, T-cell phenotype of malignant cells, visceral involvement, hypercalcemia, lytic bone lesions, and skin lesions) are encouraged to report[cdc.gov]

  • Refractory Anemia

    Peripheral blood smear The peripheral blood frequently shows abnormal cytoplasmic granularity and nuclear segmentation of the neutrophils.[imagebank.hematology.org] A valuable clue to the diagnosis of either β- or α-thalassemia minor can be the presence of moderate peripheral blood smear abnormalities despite an insignificant anemia ([aafp.org] (Outcomes/Resolutions) The severity of Refractory Anemia with Excess Blasts depends on the degree to which blast cell levels are elevated, and if Auer rods are present.[dovemed.com]

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