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241 Possible Causes for Bleeding Diathesis, Gastrointestinal Hemorrhage, Thrombocytopenic Purpura

  • Immune Thrombocytopenic Purpura

    Severe visceral bleeding (hematuria, gastrointestinal hemorrhage or cerebromeningeal bleeding) is mainly observed when thrombocytopenia is below 10,000/microL.[] Immune thrombocytopenic purpura (ITP), also called primary immune thrombocytopenia or idiopathic thrombocytopenic purpura, is an autoimmune disease affecting thrombocytes.[] A year later she presented with bleeding diathesis and was diagnosed as ITP.[]

  • Glanzmann Thrombasthenia

    Glanzmann thrombasthenia is a qualitative platelet function disorder manifested by skin bleeds, epistaxis, gingival bleeding, gastrointestinal hemorrhage, hematuria, hemarthrosis[] Acquired Glanzmann's thrombasthenia (GT) is an uncommon accompaniment to immune thrombocytopenic purpura.[] Patients with Glanzmann thrombasthenia experience lifelong spontaneous and post-traumatic mucocutaneous bleeding diathesis.[]

  • Thrombocytopathy

    Symptoms and Signs Symptoms of thrombocytopahy include: abnormal blood clotting, prolonged bleeding time, hemorrhage, excessive bleeding, abnormal blood platelet function,[] Thrombocytopenic purpura thrombocytopenic purpura n. See idiopathic thrombocytopenic purpura.[] Patients with thrombocytopathy due to storage pool disease mostly suffer from mild bleeding diathesis. However surgical interventions can lead to excess bleeding.[]

  • Acquired Hemophilia A

    […] and associated with soft tissue and the gastrointestinal system.[] ., idiopathic thrombocytopenic purpura, thrombotic thrombocytopenic purpura, connective tissue disorders and autoimmune hemolytic anemia) in which it has been used with the[] In any elderly patient with a bleeding diathesis and an abnormality in intrinsic coagulation, the presence of inhibitors to factor VIII should be suspected.[]

  • Von Willebrand Disease

    Summary Clinical description The disease manifests as mucocutaneous bleeding anomalies (menorrhagia, epistaxis, gastrointestinal hemorrhage etc. ).[] An infant with presumed maternal immune thrombocytopenic purpura had persistent thrombocytopenia with platelet clumping.[] This leads to an increased removal of VWF multimers from the circulation as well as platelets and this results in a bleeding diathesis.[]

  • Hereditary Factor XIIIA Deficiency

    Severely affected individuals have an increased risk of bleeding inside the skull (intracranial hemorrhage), in the lungs (pulmonary hemorrhage), or in the gastrointestinal[] Purpura Vasculitides The Antiphospholipid Syndrome Overview of Therapeutic Agents Used in Thrombotic Pharmacology and Mode of Action of Heparin Biochemistry Pharmacology[] History The bleeding diathesis in inherited factor XIII (FXIII) deficiency is severe in most patients.[]

  • Acute Liver Failure

    The use of gastrointestinal hemorrhage prophylaxis with a histamine-2 (H2) blocker, proton pump inhibitor, or sucralfate is recommended.[] Eltrombopag is an oral thrombopoietin receptor agonist approved for the treatment of patients with chronic idiopathic thrombocytopenic purpura (ITP), who are more than 1 year[] CONCLUSIONS: Despite a perceived bleeding diathesis, clinically significant bleeding is uncommon in patients with ALF; bleeding complications in patients with ALF are markers[]

  • Wiskott Aldrich Syndrome

    In 30% of cases, life-threatening gastrointestinal or intracranial hemorrhage can occur. Skin changes - Eczema in infancy and childhood is a constitutive feature of WAS.[] We report the case of a 3-year-old immigrant boy presenting with persistent infant-onset thrombocytopenia treated for refractory immune thrombocytopenic purpura.[] We present a case of a male with WAS, profound thrombocytopenia, and bleeding diathesis successfully managed with eltrombopag before HSCT.[]

  • Essential Thrombocythemia

    hemorrhages and arterial or venous thrombosis.[] ( D47.3 ) hemorrhagic thrombocythemia ( D47.3 ) purpura fulminans ( D65 ) thrombotic thrombocytopenic purpura ( M31.1 ) Waldenström hypergammaglobulinemic purpura ( D89.0[] diathesis 30.[]

  • Hemophilia

    […] and gastrointestinal hemorrhage.[] Rituximab chimeric anti-CD20 monoclonal antibody treatment for adults with chronic idiopathic thrombocytopenic purpura. Blood 2001; 98: 952-957. 84 Wiestner A. et al.[] Results We showed that platelet-FVIII expression was sustained and the bleeding diathesis was restored in FVIII null mice after 2bF8LV gene therapy.[]

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