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241 Possible Causes for Bleeding Diathesis, Gastrointestinal Hemorrhage, Thrombocytopenic Purpura

  • Immune Thrombocytopenic Purpura

    Severe visceral bleeding (hematuria, gastrointestinal hemorrhage or cerebromeningeal bleeding) is mainly observed when thrombocytopenia is below 10,000/microL.[orpha.net] Immune thrombocytopenic purpura (ITP), also called primary immune thrombocytopenia or idiopathic thrombocytopenic purpura, is an autoimmune disease affecting thrombocytes.[symptoma.com] A year later she presented with bleeding diathesis and was diagnosed as ITP.[ncbi.nlm.nih.gov]

  • Glanzmann Thrombasthenia

    Glanzmann thrombasthenia is a qualitative platelet function disorder manifested by skin bleeds, epistaxis, gingival bleeding, gastrointestinal hemorrhage, hematuria, hemarthrosis[ncbi.nlm.nih.gov] Acquired Glanzmann's thrombasthenia (GT) is an uncommon accompaniment to immune thrombocytopenic purpura.[ncbi.nlm.nih.gov] Patients with Glanzmann thrombasthenia experience lifelong spontaneous and post-traumatic mucocutaneous bleeding diathesis.[ncbi.nlm.nih.gov]

  • Thrombocytopathy

    Symptoms and Signs Symptoms of thrombocytopahy include: abnormal blood clotting, prolonged bleeding time, hemorrhage, excessive bleeding, abnormal blood platelet function,[medigest.uk] Thrombocytopenic purpura thrombocytopenic purpura n. See idiopathic thrombocytopenic purpura.[definithing.com] Patients with thrombocytopathy due to storage pool disease mostly suffer from mild bleeding diathesis. However surgical interventions can lead to excess bleeding.[ncbi.nlm.nih.gov]

  • Acquired Hemophilia A

    […] and associated with soft tissue and the gastrointestinal system.[ncbi.nlm.nih.gov] ., idiopathic thrombocytopenic purpura, thrombotic thrombocytopenic purpura, connective tissue disorders and autoimmune hemolytic anemia) in which it has been used with the[ncbi.nlm.nih.gov] In any elderly patient with a bleeding diathesis and an abnormality in intrinsic coagulation, the presence of inhibitors to factor VIII should be suspected.[ncbi.nlm.nih.gov]

  • Von Willebrand Disease

    Summary Clinical description The disease manifests as mucocutaneous bleeding anomalies (menorrhagia, epistaxis, gastrointestinal hemorrhage etc. ).[orpha.net] An infant with presumed maternal immune thrombocytopenic purpura had persistent thrombocytopenia with platelet clumping.[ncbi.nlm.nih.gov] This leads to an increased removal of VWF multimers from the circulation as well as platelets and this results in a bleeding diathesis.[ncbi.nlm.nih.gov]

  • Hereditary Factor XIIIA Deficiency

    Severely affected individuals have an increased risk of bleeding inside the skull (intracranial hemorrhage), in the lungs (pulmonary hemorrhage), or in the gastrointestinal[icdlist.com] Purpura Vasculitides The Antiphospholipid Syndrome Overview of Therapeutic Agents Used in Thrombotic Pharmacology and Mode of Action of Heparin Biochemistry Pharmacology[books.google.com] History The bleeding diathesis in inherited factor XIII (FXIII) deficiency is severe in most patients.[emedicine.medscape.com]

  • Acute Liver Failure

    The use of gastrointestinal hemorrhage prophylaxis with a histamine-2 (H2) blocker, proton pump inhibitor, or sucralfate is recommended.[en.wikipedia.org] Eltrombopag is an oral thrombopoietin receptor agonist approved for the treatment of patients with chronic idiopathic thrombocytopenic purpura (ITP), who are more than 1 year[ncbi.nlm.nih.gov] CONCLUSIONS: Despite a perceived bleeding diathesis, clinically significant bleeding is uncommon in patients with ALF; bleeding complications in patients with ALF are markers[ncbi.nlm.nih.gov]

  • Wiskott Aldrich Syndrome

    In 30% of cases, life-threatening gastrointestinal or intracranial hemorrhage can occur. Skin changes - Eczema in infancy and childhood is a constitutive feature of WAS.[symptoma.com] We report the case of a 3-year-old immigrant boy presenting with persistent infant-onset thrombocytopenia treated for refractory immune thrombocytopenic purpura.[ncbi.nlm.nih.gov] We present a case of a male with WAS, profound thrombocytopenia, and bleeding diathesis successfully managed with eltrombopag before HSCT.[ncbi.nlm.nih.gov]

  • Essential Thrombocythemia

    hemorrhages and arterial or venous thrombosis.[ncbi.nlm.nih.gov] ( D47.3 ) hemorrhagic thrombocythemia ( D47.3 ) purpura fulminans ( D65 ) thrombotic thrombocytopenic purpura ( M31.1 ) Waldenström hypergammaglobulinemic purpura ( D89.0[icd10data.com] diathesis 30.[nature.com]

  • Hemophilia

    […] and gastrointestinal hemorrhage.[doi.org] Rituximab chimeric anti-CD20 monoclonal antibody treatment for adults with chronic idiopathic thrombocytopenic purpura. Blood 2001; 98: 952-957. 84 Wiestner A. et al.[doi.org] Results We showed that platelet-FVIII expression was sustained and the bleeding diathesis was restored in FVIII null mice after 2bF8LV gene therapy.[ncbi.nlm.nih.gov]

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