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43 Possible Causes for Bleeding Diathesis, Iron Increased, Reticulocyte Count Decreased

  • Aplastic Anemia

    Although the GI bleed could be explained by portal hypertension and gastropathy, the epistaxis was likely due to a bleeding diathesis secondary to thrombocytopenia.[] For example, for a person with anemia, an inappropriately low reticulocyte count often indicates decrease in red blood cell production in the bone marrow .[] We studied 4 adult AA patients who had transfusion-induced iron overload and showed hematological improvement after ICT with oral deferasirox.[]

  • Acute Myelocytic Leukemia

    An iron stain usually shows increased iron stores and may show ring sideroblasts (Figure 2, B [inset]).[] A general bleeding diathesis may be the result of thrombocytopenia. Patients may claim a propensity for epistaxis, bleeding gums, melena and hematochezia, and hematuria.[] The potential for neurotoxicity has aroused concern about the use of high-dose cytarabine in elderly patients who, ironically, have a higher likelihood of having drug-resistant[]

  • Leukemia

    Leukemia is cancer of the blood forming tissues that also affects the bone marrow and the lymphatic system. Such a type of cancer causes abnormal development of cells that gradually enter the bloodstream. Symptoms of leukemia vary with the type. The common symptoms of the disease include the following: Undue[…][]

  • Acute Myeloid Leukemia with Myelodysplasia-related Changes

    Mitochondrial pathology in MDS is suggested by abnormal mitochondrial iron accumulation, increased apoptosis, and a high frequency of acquired mitochondrial DNA mutations[]

  • Chronic Kidney Insufficiency

    Because of increased iron utilization with stimulated erythropoiesis, iron stores must be replaced, often requiring parenteral iron.[] Hypocalcemia (see chapter) Hyponatremia (see chapter) Uremia: The three most severe forms of uremia are encephalopathy, bleeding diathesis, and pericarditis.[] Iron therapy can help increase levels of iron in the body when EPO therapy alone is not effective. Vitamin D helps keep bones strong and healthy.[]

  • Myeloproliferative Disease

    Defects in glycoprotein (GP)IIb-IIIa or in its activation may cause abnormal platelet aggregation and a bleeding diathesis.[] […] mean normal predicted value. 9.  Increased RBC count and Hgb levels (except when iron deficient)  Elevated RBC mass  Panmyelosis in the bone marrow  Low EPO level  Positive[] ., iron deficiency or bleeding).[]

  • Severe Aplastic Anemia

    In SAA patients, complete blood count and reticulocyte count usually reveal pancytopenia and decreased levels of reticulocytes; lymphopenia is rare.[] Stainable iron is usually increased; however, the presence of increased ringed sideroblasts suggests a diagnosis of MDS.[] In our case, the patient presented with bleeding due to thrombocytopenia.[]

  • Leukoerythroblastic Anemia

    Decreased count - reticulocyte levels drop where there is marrow infiltration (leukaemia, myeloma, lymphoma or other malignancies) or due to marrow underactivity such as in[] RBC protoporphyrin increased BM- ringed sideroblasts Iron studies- Increased serum iron, increased iron saturation, increased ferritin- Decreased TIBC Anemia of Chronic Disease[] […] anemia, Sideroblastic anemia Blood tests Normocytic - Microcytic - Macrocytic - Normochromic - Hypochromic Other Methemoglobinemia Coagulation / platelets / coagulopathy / bleeding[]

  • Myelodysplasia

    It may present as a bleeding diathesis with haemoptysis, haematuria or rectal bleeding.[] Red blood cells contain iron, so if you have a lot of blood transfusions, the level of iron in your body will increase.[] diathesis ( 5 – 7 ).[]

  • Primary Myelofibrosis

    , and polychromatophilia and very elevated reticulocyte counts can occur. 263,264 The antiglobulin (Coombs) test usually is negative, but red cell autoantibodies can develop[] […] for the increase in hemoglobin levels.[] In general, laboratory analyses of blood samples are carried out in order to clarify the causes of persistent fatigue, recurrent infections, thrombosis or bleeding diathesis[]

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