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260 Possible Causes for Bleeding Diathesis, Oral Bleeding, Thrombocytopenic Purpura

  • Immune Thrombocytopenic Purpura

    In some instances there is oral bleeding, epistaxis, rectal bleeding or haematuria. Morbidity in ITP is usually minimal and parents need to be reassured of this.[rch.org.au] Immune thrombocytopenic purpura (ITP), also called primary immune thrombocytopenia or idiopathic thrombocytopenic purpura, is an autoimmune disease affecting thrombocytes.[symptoma.com] A year later she presented with bleeding diathesis and was diagnosed as ITP.[ncbi.nlm.nih.gov]

  • Disseminated Intravascular Coagulation

    Oral administration of 1,500 mg tranexamic acid per day stabilized the coagulative and fibrinolytic parameters and relieved bleeding tendencies with no side effects.[ncbi.nlm.nih.gov] We report on 3 male neonates with hereditary ADAMTS13 deficiency (Upshaw Schulman syndrome, USS), the inherited form of thrombotic thrombocytopenic purpura (TTP). 2 presented[ncbi.nlm.nih.gov] Bleeding diathesis must be corrected before surgery in order to prevent massive intraoperative bleeding.[kjim.org]

  • Glanzmann Thrombasthenia

    GT is a rare hematological disorder with oral manifestations affecting platelets and clotting.[ncbi.nlm.nih.gov] Acquired Glanzmann's thrombasthenia (GT) is an uncommon accompaniment to immune thrombocytopenic purpura.[ncbi.nlm.nih.gov] Patients with Glanzmann thrombasthenia experience lifelong spontaneous and post-traumatic mucocutaneous bleeding diathesis.[ncbi.nlm.nih.gov]

  • Coagulation Abnormalities

    […] anticoagulation Oral anticoagulant drugs such as coumadin are responsible for many adverse drug reactions.[rnceus.com] Cancer patients may also suffer from the impediment of hemolytic uremic syndrome or thrombotic thrombocytopenic purpura (HUS/TTP).[als-journal.com] diathesis.[ncbi.nlm.nih.gov]

  • Thrombocytopenia

    Good oral care (using oral swabs, a normal saline rinse, or other mouthwash as appropriate) helps to keep mucous membranes moist and minimize bleeding.[americannursetoday.com] Abstract Thrombotic thrombocytopenic purpura (TTP) is an acute, life-threatening illness with disseminated platelet-rich thromboses of small vessels that variably presents[ncbi.nlm.nih.gov] Clinical diagnosis Bleeding diathesis probably related to low platelets.[wjgnet.com]

  • Aplastic Anemia

    […] gums Fevers Sinus tenderness Enlarged liver or spleen Oral thrush (white patches on a red, moist, swollen surface, occurring anywhere in the mouth) The symptoms of aplastic[chop.edu] Acquired amegakaryocytic thrombocytopenic purpura (AATP) is a rare hematological disorder characterized by severe thrombocytopenia and a complete or near-to complete absence[ncbi.nlm.nih.gov] Although the GI bleed could be explained by portal hypertension and gastropathy, the epistaxis was likely due to a bleeding diathesis secondary to thrombocytopenia.[jscisociety.com]

  • Acquired Coagulation Factor Deficiency

    Common clinical signs include epistaxis, menorrhagia, oral cavity bleedings, mucosal bleeding, soft tissue bleeding, hemarthroses, easy bruising, and prolonged bleeding after[orpha.net] ( D47.3 ) purpura fulminans ( D65 ) thrombotic thrombocytopenic purpura ( M31.1 ) D69.0 Allergic purpura Purpura: · anaphylactoid · Henoch(-Schönlein) · nonthrombocytopenic[apps.who.int] They did not require any plasma or plasma product for the control of their bleeding diathesis and decreased factor IX activity returned to normal in a relatively short period[karger.com]

  • Von Willebrand Disease

    Can treat oral bleeding with a mouth-wash of TXA! Crush tablets in 10-15ml of water and have patient hold that in their mouth for 5 min before swallowing.[pedemmorsels.com] An infant with presumed maternal immune thrombocytopenic purpura had persistent thrombocytopenia with platelet clumping.[ncbi.nlm.nih.gov] This leads to an increased removal of VWF multimers from the circulation as well as platelets and this results in a bleeding diathesis.[ncbi.nlm.nih.gov]

  • Hereditary Factor XIIIA Deficiency

    bleeding Neurologic findings commensurate with CNS hemorrhage Bleeding in the oral cavity Hemarthroses or periarticular bleeding Poor wound healing Author Helge Dirk Hartung[emedicine.medscape.com] Purpura Vasculitides The Antiphospholipid Syndrome Overview of Therapeutic Agents Used in Thrombotic Pharmacology and Mode of Action of Heparin Biochemistry Pharmacology[books.google.com] In situations where bleeding does not stop quickly or more serious bleeds or trauma, oral agents (eg. antifibrinolytic medications), and/or factor XIII replacement may be[rarebleedingdisorders.com]

  • Wiskott Aldrich Syndrome

    In most cases the first clinical features are hemorrhagic manifestations with petechiae, bruising, purpura, epistaxis, oral bleeding, bloody diarrhea and intracranial bleeding[orpha.net] We report the case of a 3-year-old immigrant boy presenting with persistent infant-onset thrombocytopenia treated for refractory immune thrombocytopenic purpura.[ncbi.nlm.nih.gov] We present a case of a male with WAS, profound thrombocytopenia, and bleeding diathesis successfully managed with eltrombopag before HSCT.[ncbi.nlm.nih.gov]

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