Bleeding Episodes: Causes & Reasons

Possible Causes for Bleeding Episodes

Congenital Disorder of Glycosylation Type 1B

This study also showed that in patients with large varices, the 1-year probability of first bleeding episode despite primary prophylaxis was 9 %. [ojrd.biomedcentral.com]

The accelerated phase is associated with fever, episodes of abnormal bleeding, overwhelming infections and organ failure. [primaryimmune.org]

Symptoms include recurrent episodes of vomiting, protein-losing enteropathy, bleeding diathesis and recurrent thrombosis, liver disease, and hypoglycemia. [pediatrics.aappublications.org]

Hemophilia

(prophylaxis) measure to reduce the frequency of bleeding episodes. [fda.gov]

Prophylactic treatment can also help reduce bleeding episodes. [symptoma.com]

This may be referred to as prolonged bleeding or a prolonged bleeding episode. [rarediseases.org]

Esophageal Varices

It is important to understand the factors related with a bleeding episode to evaluate more effective primary prophylaxis. [ncbi.nlm.nih.gov]

Once the acute bleeding episode has been controlled, it is important to prevent further haemorrhage as there is a 30 to 40% mortality rate associated with each bleeding episode [hepatitiscentral.com]

The most serious complication of esophageal varices is bleeding. Once there is one bleeding episode there is the risk of another bleeding episode. [giforkids.com]

Mallory-Weiss Syndrome

Mallory-Weiss syndrome is the cause of about 5% of bleeding episodes in the upper digestive tract (see also Gastrointestinal Bleeding ). [merckmanuals.com]

Measures to stop the bleeding Most bleeding episodes stop by themselves, but sometimes the doctor must do endoscopy and take measures to stop the bleeding. [msdmanuals.com]

Most episodes of bleeding stop spontaneously; severe bleeding occurs in about 10% of patients, who require significant intervention, such as transfusion or endoscopic hemostasis [merckmanuals.com]

Hemophilic Arthropathy

Their odds ratios (OR) were 1.29 (factor replacement), 1.17 (numbers of joint bleeding episodes), and 1.73 (number of arthropathic joints), which were significant (P < 0.05 [ncbi.nlm.nih.gov]

Abstract Hemophilia leads to recurrent bleeding episodes in joints resulting in a severe destructive arthropathy in many cases. [ncbi.nlm.nih.gov]

Abstract Open and arthroscopic synovectomies of the knee in patients with classic hemophilia were evaluated with regard to effectiveness in reducing bleeding episodes, the [ncbi.nlm.nih.gov]

Glanzmann Thrombasthenia

Re-bleeding For 738 episodes for which data on the re-bleeding status were available, 45 re-bleeds in 25 patients were registered: 19/189 (10.1%) severe bleeding episodes, [haematologica.org]

The international, prospective Glanzmann Thrombasthenia Registry: treatment modalities and outcomes of non-surgical bleeding episodes in patients with Glanzmann thrombasthenia [haematologica.org]

26/549 (4.7%) moderate bleeding episodes, 18/478 (3.8%) bleeds in patients without antibodies or refractoriness and 27/260 (10.4%) bleeding episodes in patients with a history [haematologica.org]

Acquired Coagulation Factor Deficiency

Our study suggests that prothrombin complex concentrates have predictable effectiveness in acquired hypoprothrombinemic bleeding episodes only when coagulation deficiencies [annals.org]

[…] thrombasthenia noun An abnormality of platelets. verenvuototauti noun Varsi NovoSeven is used to treat bleeding episodes and to prevent excessive bleeding connected with surgery [fi.glosbe.com]

[…] periods In more severe cases, symptoms can include: destruction of cartilage in joints from bleeding episodes bleeding in the intestines, stomach, muscles, or head excessive [healthline.com]

Small Intestinal Angiodysplasia

Bleeding episodes were not accompanied by an increase in inflammation parameters or increased clinical activity. [gut.bmj.com]

In small cohort studies octreotide appears to decrease the bleeding episodes in those patients, but the evidence is still to weak to integrate this treatment modality in daily [clinicaltrials.gov]

Other patients may have occasional bleeding episodes with bright red blood from the rectum. [clinicaladvisor.com]

Acquired Von Willebrand Syndrome

BACKGROUND: Of patients with severe aortic stenosis, 15-25% present with bleeding episodes possibly attributable to acquired von Willebrand syndrome (AVWS). [ncbi.nlm.nih.gov]

We present a woman (age: 57 years) with an excessive bleeding episode under acetylsalicylic acid after bone marrow puncture due to an acquired von Willebrand syndrome (avWS [ncbi.nlm.nih.gov]

Recurrent bleeding episodes occur in approximately 20 to 33% of patients with AVWS, especially following major trauma and surgery. [ncbi.nlm.nih.gov]

Acquired Factor XIII Deficiency

Prophylaxis may be appropriate in children with recurrent serious bleeding and specifically after life-threatening bleeding episodes. [pediatrics.aappublications.org]

Three major bleeding episodes occurred, as demonstrated by sudden rises in requirements. [anesthesiology.pubs.asahq.org]

The aim of this clinical trial is to investigate long-term safety of rFXIII when administered for prevention of bleeding episodes in children aged between 1 and 6 years with [clinicaltrials.gov]

Colonic Angiodysplasia

Hormonal therapy One RCT - few episodes of bleeding, decrease transfusion requirement van Cutsem E et al. [slideplayer.com]

Symptoms vary, often in the elderly are: weakness, anemia, fatigue and tahipnee.Alti patients have mild or severe bleeding episodes, with the elimination of the red blood [medicaldb.blogspot.com]

Abstract Colonic angiodysplasia (AGD) is an important cause of lower gastrointestinal bleeding. However, most episodes of bleeding from colonic AGD stop spontaneously. [ncbi.nlm.nih.gov]

Hemophilia A

This may be referred to as prolonged bleeding or a prolonged bleeding episode. [rarediseases.org]

bleeding episodes. [healio.com]

episodes and as prophylaxis to prevent bleeding. [medpagetoday.com]

Von Willebrand Disease

[…] spontaneous bleeding episodes in the same joint in the six months prior to enrollment; or three or more apparently spontaneous bleeding episodes in different joints in the [clinicaltrials.gov]

INTRODUCTION: Reducing bleeding episodes is very important in haematology disorders like von Willebrand disease (VWD) and Glanzmann thrombasthenia (GT). [ncbi.nlm.nih.gov]

which can induce acute bleeding episodes during critical surgical procedures. [ncbi.nlm.nih.gov]

Congenital Alpha-2-Antiplasmin Deficiency

Clinical studies showed that 2 heterozygotes had a mild bleeding tendency, which presented as bleeding episodes after tooth extraction and after surgery and, in one patient [unboundmedicine.com]

This is striking, as normally severe PAI-1 deficiency is associated with recurrent bleeding episodes. [austinpublishinggroup.com]

episodes. [austinpublishinggroup.com]

Hereditary Factor X Deficiency

traumatic and heavy menstrual bleeding episodes. [empr.com]

The study included 16 participants who experienced a combined 208 bleeding episodes. [healio.com]

episodes, and for perioperative management of bleeding in patients with mild hereditary Factor X deficiency. [europeanpharmaceuticalreview.com]

Hereditary Factor I Deficiency

RiaSTAP ®, Fibrinogen Concentrate (Human), is indicated for the treatment of acute bleeding episodes in patients with congenital fibrinogen deficiency, including afibrinogenemia [riastap.com]

Early diagnosis of congenital afibrinogenemia can allow treatment initiation and prevent individuals from having severe bleeding episodes, particularly bleeding inside the [rarediseases.org]

episodes are usually mild Dysfibrinogenemia (qualitative deficiency) Qualitative deficiency in which individuals have normal levels of fibrinogen (200 to 450 mg/dL) but circulating [riastap.com]

Hereditary Factor XIII Deficiency

Five spontaneous bleeding episodes (involving three patients; none requiring FXIII treatment) and eight trauma-related bleeding episodes (two requiring FXIII treatment) occurred [ncbi.nlm.nih.gov]

This higher dose did not trigger thrombotic events but significantly decreased bleeding episodes and prevented the occurrence of major bleeding. [ncbi.nlm.nih.gov]

We conclude that rFXIII is safe and effective in preventing bleeding episodes in patients with congenital FXIII-A subunit deficiency. [ncbi.nlm.nih.gov]

Hereditary Factor XIIIA Deficiency

Nevertheless, this condition should be considered in patients experiencing bleeding episodes without an identifiable cause. [symptoma.com]

[…] of bleeding episodes. [rxlist.com]

If the condition is not treated, affected individuals may have episodes of excessive and prolonged bleeding that can be life-threatening. [ghr.nlm.nih.gov]

Acquired Hemophilia

Physician-rated efficacy of rFVIIa for each bleeding episode was reported as 'bleeding stopped' in 85% of bleeding episodes, 'bleeding slowed' in 11% of bleeding episodes, [ncbi.nlm.nih.gov]

In most cases, bleeding episodes are spontaneous and severe at presentation. The optimal hemostatic therapy is controversial. [ncbi.nlm.nih.gov]

A Phase II/III study in AHA with serious bleeding episodes shows a positive response in all subjects after administration. [ncbi.nlm.nih.gov]

Factor VII Deficiency

[…] with FVII deficiency (N=75) treated with NovoSeven ® for 124 bleeding episodes, surgeries, or prophylaxis regimens. [novosevenrtpro.com]

Key assessments: The database is set up to capture the following assessments, if available: Bleeding episodes: • Recording of bleeding location, symptom onset and treatment [clinicaltrials.gov]

Recombinant activated factor VII (rFVIIa) was used to treat 49 bleeding episodes in 8 patients after 2002. [ncbi.nlm.nih.gov]

Factor X Deficiency

episodes, and perioperative management of bleeding in patients with mild hereditary factor X deficiency. [prnewswire.com]

To date, 34 of 102 patients have been treated for severe bleeding episodes or for surgical procedures. [ncbi.nlm.nih.gov]

The study included 16 participants who experienced a combined 208 bleeding episodes. [healio.com]

Factor II Deficiency

Two patients had clinically significant bleeding episodes. [ncbi.nlm.nih.gov]

[…] and control bleeding episodes. [healthline.com]

Serious bleeding episodes were more frequent in the group given M/T than in that given T/T (10 and two patients, respectively; P less than or equal to .05). [ncbi.nlm.nih.gov]

Thrombocytopenia-Absent Radius Syndrome

TAR syndrome also causes life-threatening bleeding episodes due to low levels of platelets in the blood (thrombocytopenia). [flowvella.com]

Consequently, thrombocytopenia results in potentially severe bleeding episodes (hemorrhaging) primarily during infancy. [birthdefects.org]

episodes in the first year of life. [uniprot.org]

Hereditary Coagulopathy

When the oral bleedings alone were considered, a total number of 91 individuals reported to the society with 153 episodes of gingival bleeding and 24 individuals with 26 episodes [jdrntruhs.org]

Episodes of bleeding can be prevented by avoiding injury. [healthofchildren.com]

Women may experience heavy menstrual bleeding, bleeding from the gums or nose, bleeding deep within the skin, and episodes of bleeding into the stomach, intestine, and urinary [medical-dictionary.thefreedictionary.com]

Jejunal Vascular Anomaly with Hemorrhage

The complications from Colonic Arteriovenous Malformation could include: Chronic and recurrent bleeding Emotional trauma due to chronic bleeding episodes Severe and acute [dovemed.com]

No additional episodes of bleeding were reported, and the patient’s hemoglobin and hematocrit levels stabilized. [gastroenterologyandhepatology.net]

Early endoscopy was nondiagnostic during the first bleeding episode in all nine patients with nonhereditary vascular malformations; the diagnosis was eventually made after [link.springer.com]

Bernard-Soulier Syndrome

Here, we describe the use of rFVIIa for the treatment of three severe bleeding episodes in two patients with BSS. [ncbi.nlm.nih.gov]

Depending on the phenotype, patients present with bleeding episodes of variable severity. [symptoma.com]

The majority of patients (60%) had mild bleeding episodes, but 39 (40%) had at least one episode of severe bleeding in their past history. [ncbi.nlm.nih.gov]

Acquired Hemophilia A

In most cases, bleeding episodes are spontaneous and severe at presentation. The optimal hemostatic therapy is controversial. [ncbi.nlm.nih.gov]

A Phase II/III study in AHA with serious bleeding episodes shows a positive response in all subjects after administration. [ncbi.nlm.nih.gov]

The treatment involves two aspects-eradication of antibodies and maintaining effective hemostasis during a bleeding episode. [ncbi.nlm.nih.gov]

Hemophilia B

(prophylaxis) measure to reduce the frequency of bleeding episodes. [fda.gov]

People with moderate hemophilia B tend to have bleeding episodes after injuries. Bleeds that occur without obvious cause are called spontaneous bleeding episodes. [hawaiinhf.org]

Idelvion was demonstrated to be effective in controlling bleeding episodes and in managing perioperative bleeding. [fda.gov]

Factor V Deficiency

The severity of bleeding episodes in our patients was compared with other RBDs. [ncbi.nlm.nih.gov]

The majority of bleeding episodes were controlled with local measures and fresh-frozen plasma replacement. [ncbi.nlm.nih.gov]

We report a homozygous nucleotide change (G6395A) in two Tunisian probands with Factor V deficiency and bleeding episodes. [ncbi.nlm.nih.gov]

Bleeding Diathesis

A 49-year-old male with alcoholic cirrhosis suffered several spontaneous, life-threatening, deep muscle bleeding episodes. [ncbi.nlm.nih.gov]

Abstract Haemophilia B patients with factor IX (FIX) activity < 1% are usually characterized by severe bleeding episodes early in life. [ncbi.nlm.nih.gov]

Abstract Patients with hemophilia A and B and factor levels than 1 percent of normal bleed frequently with an average number of spontaneous bleeding episodes of 20-30 or more [ncbi.nlm.nih.gov]