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168 Possible Causes for Bleeding Gums, Bone Pain, Macrocytosis

  • Multiple Myeloma

    (who, 2001) Malignant neoplasm of plasma cells usually arising in the bone marrow and manifested by skeletal destruction, bone pain, and the presence of anomalous immunoglobulins[icd9data.com] – such as frequent nosebleeds, bleeding gums and heavy periods Myeloma doesn't usually cause a lump or tumour.[nhs.uk] However, if you have these symptoms, you should call your doctor right away: Fever Bleeding (such as nosebleeds, bleeding gums or severe bruising) Skin rash Cough that doesn[familydoctor.org]

  • Infantile Scurvy

    Patients may present with lethargy and malaise, bone pain, bleeding diathesis (e.g. bleeding gums), and impaired wound healing.[radiopaedia.org] Signs of scurvy include tiredness, muscle weakness, joint and muscle aches, a rash on the legs, and bleeding gums.[medical-dictionary.thefreedictionary.com] pain.[medcaretips.com]

  • Myeloproliferative Disease

    Symptoms Signs  Fatigue  Malaise  Early satiety  Weight loss  Fever  Abdominal painBone pain  Pruritis  Splenomegaly  Abnormal blood counts  Abnormal peripheral[slideshare.net] , and/or symptoms of thrombosis Nosebleeds Headache Vision problems Bleeding gums Gastrointestinal bleeding Blood in the urine High blood pressure Blockage of blood vessels[diagnose-me.com] Abstract Children with Down syndrome (DS) display macrocytosis, thrombocytosis, and a 500-fold increased risk of developing megakaryocytic leukemia; however, the specific[ncbi.nlm.nih.gov]

  • B Acute Lymphoblastic Leukemia

    .: Germline mutations in ETV6 are associated with thrombocytopenia, red cell macrocytosis and predisposition to lymphoblastic leukemia. Nat Genet 47 (5): 535-8, 2015.[cancer.gov] Bone pain is relatively common and described in approximately 50% of patients (1, 7). Pain may also occur in the course of the disease or during treatment.[jbpml.org.br] gums, or other unusual bleeding such as from minor cuts Depending upon where leukemia cells are present, other symptoms may include: A full or swollen belly from leukemia[webmd.com]

  • Acute Erythroblastic Leukemia

    Other typical symptoms include fever, pain in the joints and bones, and swelling of the lymph nodes, spleen, and liver. adj., adj leuke mic. Types of Leukemia .[medical-dictionary.thefreedictionary.com] Blood smear shows nucleated red cells at different stages with pathological features (macrocytosis, schistocytes, blast cells Bone marrow biopsy shows prevalence of erythroid[patient.info] […] from the gums, retinal hemorrhages, and infections of the respiratory tracts, urinary tracts, sinuses, peri-rectal areas, and skin.[knowcancer.com]

  • Severe Aplastic Anemia

    Mild anemia and macrocytosis may indicate SAA in patients otherwise possibly diagnosed with immune thrombocytopenic purpura.[symptoma.com] Radiation therapy- radiation may help a small number of people who have bone pain. It can also help reduce the size of the spleen, when surgical removal isn't an option.[ohsu.edu] The intraoral examination identified bleeding gums; petechiae of the palate, tongue and cheek mucosa; and an atrophic, smooth and shining dorsal surface of the tongue.[ncbi.nlm.nih.gov]

  • Vitamin B12 Deficiency

    We report a case of a 46-year-old Moroccan man presenting with severe hemolytic anemia, thrombocytopenia, and renal failure in absence of macrocytosis, thus mimicking a genuine[ncbi.nlm.nih.gov] Regarding the leg pain, it can be due to the growth of the bones and muscles in children. These generally settle down with time.[icliniq.com] gums Long-term vitamin B12 deficiency can cause: Confusion Dementia Depression Loss of balance Numbness and tingling in your hands and feet Treatment of Vitamin B12 Deficiency[everydayhealth.com]

  • Pellagra

    Osteomalacia Osteomalacia is characterized by pain, sometimes severe, in bones, particularly in the pelvis, lower back and legs.[fao.org] FEX: Use of case definitions and awareness of micronutrient deficiencies Summary of Unpublished Study* Afgani boy with swollen and bleeding gums typical of scurvy.[ennonline.net] It famously afflicted sailors exploring the New World, and its symptoms include fatigue; irritability; depression; and bleeding from the gums, under the skin, and around bones[pbslearningmedia.org]

  • Vitamin Deficiency

    […] erythropoiesis (formation of erythrocytes), it is important for pharmacists to note that microcytosis (low mean corpuscle volume: [MCV]) should suggest sideroblastic anemia, while macrocytosis[uspharmacist.com] Vitamin D – bowing of legs in children, periosteal bone pain and osteomalacia in adults.[symptoma.com] Bleeding gums Take care of your teeth properly and if you still have bleeding gums, it can indicate a vitamin deficiency.[dokteronline.com]

  • Gingivitis

    Periodontal disease is a severe and painful infection that has spread extensively through the soft gum tissues and may be attacking the nearby bone.[dhamadison.com] What Diseases Can Cause my Gums to Bleed? Periodontitis (or gum disease) is one of the leading causes of bleeding gums.[bleedinggums.com] Moreover, of the 92 GPCA /DG /EOLP patients, 24 had macrocytosis, and only 13 (54.2%) of these 24 patients had pernicious anemia.[ncbi.nlm.nih.gov]

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