Papillon Lefevre syndrome (PLS) is characterized by palmoplantar hyperkeratosis, severe periodontitis and premature loss of teeth.
[e-ijd.org]
recurrent infections, fever, arthralgias, infection, anorexia, night sweats, shortness of breath, bony tenderness, epistaxis, bleeding gums, gingival hyperplasia pallor,
[bestpractice.bmj.com]
Skin may be thin and velvety with sparse, delicate hair in facial, pubic, and axillary regions.
[clinicaladvisor.com]