Bleeding Time Prolonged: Causes & Reasons

Possible Causes for Bleeding Time Prolonged

Although hemarthrosis of GT is rare, this disease should be considered in a patient with bleeding tendency and prolonged bleeding time. [ncbi.nlm.nih.gov]

As a result, no fibrinogen bridging of platelets to other platelets can occur, and the bleeding time is significantly prolonged. [snpedia.com]

Bleeding time was prolonged in 92%. [ncbi.nlm.nih.gov]

Bernard-Soulier Syndrome

In addition to these findings, prolonged skin bleeding time is also a constitutive feature of Bernard-Soulier syndrome. [symptoma.com]

We studied two brothers with moderate bleeding symptoms. Bleeding time was prolonged and ristocetin-induced platelet aggregation was absent. [ncbi.nlm.nih.gov]

Historical Aspects The first patient had been published by Bernard and Soulier in 1948--a young man with a severe bleeding disorder: prolonged bleeding time, thrombocytopenia [moldiag.com]

Platelet-Type Bleeding Disorder 18

Related phenotypes are epistaxis and prolonged bleeding time UniProtKB/Swiss-Prot : 76 Bleeding disorder, platelet-type 18: A disorder characterized by increased bleeding [malacards.org]

Thus, abnormalities of platelet glycoproteins, platelet granules, and signal transduction and secretion can all result in hemorrhagic diatheses and prolonged bleeding times [accessmedicine.mhmedical.com]

Hemostatic disorder of uremia: the platelet defect, main determinant of the prolonged bleeding time, is correlated with indices of activation of coagulation and fibrinolysis [medicinaylaboratorio.com]

Factor II Deficiency

Diagnosis Prolonged bleeding time and sometimes prolonged activated partial thromboplastin time ( aPTT ) ↓ Factor VIII levels vWF -specific measurements Therapy : only if [amboss.com]

Normal or reduced Bleeding time Normal Normal or prolonged Prothrombin time Normal Normal Activated partial thromboplastin time Prolonged Normal or prolonged Table 3 Screening [academic.oup.com]

LA-HPS is to be suspected when a patient presents with bleeding and a prolonged activated partial thromboplastin and prothrombin time, in combination with a lupus anticoagulant [ncbi.nlm.nih.gov]

Platelet-Type von Willebrand Disease

bleeding time 0003010 Showing of 3 | Last updated: 3/1/2020 If you need medical advice, you can look for doctors or other healthcare professionals who have experience with [rarediseases.info.nih.gov]

Names Learn More: HPO ID Percent of people who have these symptoms is not available through HPO Autosomal dominant inheritance 0000006 Intermittent thrombocytopenia 0004854 Prolonged [rarediseases.info.nih.gov]

Thromboxane Synthase Deficiency

[…] template bleeding time (> min). [ncbi.nlm.nih.gov]

The bleeding time was markedly prolonged by the administration of aspirin, and this prolongation was associated with the inhibition of TXB2 in the effluent blood, which seemed [ncbi.nlm.nih.gov]

A patient with a bleeding disorder characterised by a mildly prolonged bleeding time and defective platelet-release reaction due to a congenital deficiency of cyclo-oxygenase [ncbi.nlm.nih.gov]

Hemophilia

If von Willebrand factor is malformed, decreased, or absent, there is prolonged bleeding time because the platelets are unable to attach to the wall of the vessel and form [stanfordchildrens.org]

AHA should be suspected when a patient with no previous history of bleeding presents with bleeding and an unexplained prolonged activated partial thromboplastin time. [doi.org]

Bleeding can happen at any time, disrupting school or work, may cause prolonged periods of pain and disability and decrease quality of life. [ortho.ucla.edu]

Hemophilia B

bleeding after dental extraction 0006298 Prolonged bleeding after surgery Excessive bleeding during surgery Protracted bleeding after surgery [ more ] 0004846 Prolonged bleeding [rarediseases.info.nih.gov]

Despite a prolonged operation time, because of a partially intrahepatic gallbladder, no bleeding complications were registered and the patient recovered well. [ncbi.nlm.nih.gov]

time and prothrombin time Prolonged activated partial thromboplastin time (aPTT) a normal aPTT does not exclude mild or even moderate hemophilia. [medcaretips.com]

Wiskott-Aldrich Syndrome

Hemorrhagic signs can involve epistaxis, oral bleeding, hematemesis, melena, petechiae, and purpura; bleeding time is prolonged. [accessanesthesiology.mhmedical.com]

All patients had severe thrombocytopenia and prolonged bleeding times. The platelets had abnormal morphology with reduced size and variations of shape. [onlinelibrary.wiley.com]

bleeding time (difficulty in clotting). [rarediseases.org]

MACS Syndrome

bleeding time, Umbilical hernia, Sparse hair, Urethral stenosis, Thick lower lip vermilion, Sparse and thin eyebrow, Irregular dentition, Scoliosis Skip the waiting lines [fdna.health]

Gingival overgrowth, Short stature, Ichthyosis, High palate, Hypergonadotropic hypogonadism, Hyperextensible skin, High pitched voice, Joint hypermobility, Muscular hypotonia, Prolonged [fdna.health]

Aspirin-induced Platelet Defect

When purpura was evident the patient's liver function was within normal limits and her coagulation time was normal but her bleeding time was prolonged. [ncbi.nlm.nih.gov]

It is associated with thrombocytopenia, enlarged platelets, and prolonged bleeding time. [icd10data.com]

Patients on aspirin usually have only modestly prolonged bleeding times. [quizlet.com]

Thrombocytopathy

[…] activity deficiency and abnormal platelets, prolonged bleeding time, platelet coagulant activity deficiency and abnormal platelet aggregation. [ncbi.nlm.nih.gov]

Most patients had prolonged bleeding times, absent secondary wave of platelet aggregation in response to epinephrine, collagen and adenosine diphosphate (ADP), and defective [scholars.northwestern.edu]

Symptoms and Signs Symptoms of thrombocytopahy include: abnormal blood clotting, prolonged bleeding time, hemorrhage, excessive bleeding, abnormal blood platelet function, [medigest.uk]

Platelet Storage Pool Deficiency

Evidence of storage pool deficiency should be considered in all patients with an isolated unexplained prolongation of the bleeding time. [ncbi.nlm.nih.gov]

[…] episodes, prolonged bleeding time, and reduced aggregation response to collagen or thrombin. storage pool disease inadequate number or contents of platelet delta-granules [medical-dictionary.thefreedictionary.com]

It is thought that the reduced release of ADP may result in the prolonged bleeding times. [diseaseinfosearch.org]

Hereditary Coagulopathy

[…] disorder with impaired clot retraction time Blood coagulation disorder with prolonged bleeding time Blood coagulation disorder with prolonged coagulation time Blood coagulation [emedcodes.com]

[…] clot retraction time Blood coagulation disorder with prolonged bleeding time Blood coagulation disorder with prolonged coagulation time Blood coagulation disorder with shortened [icd9data.com]

DIC produces multiple coagulation test abnormalities, including: Prolonged PT and PTT times Prolonged bleeding time Decreased fibrinogen and platelet count Increased fibrinolysin [rnceus.com]

Acquired Hemophilia A

Diagnosis should be considered if there is abnormal bleeding and a prolonged activated partial thromboplastin time (aPTT). [hemophilianewstoday.com]

[…] partial thromboplastin time (APTT) and other common causes of a prolonged APTT are ruled out. [ncbi.nlm.nih.gov]

Acquired hemophilia A (AHA) should be suspected in patients with a new onset of bleeding and an isolated prolongation of activated partial thromboplastin time. [ncbi.nlm.nih.gov]

Bleeding Diathesis

Abstract In 1926 von Willebrand1 described a familial bleeding tendency affecting both sexes and characterized by a prolonged bleeding time, accompanied by a normal coagulation [annals.org]

[…] study and a prolonged bleeding time. [ncbi.nlm.nih.gov]

bleeding time of renal failure and may as a result diminish the risk of clinical hemorrhage. [ncbi.nlm.nih.gov]

Inherited Platelet Disorder

It is associated with thrombocytopenia, enlarged platelets, and prolonged bleeding time. [icd10data.com]

[…] nosebleeds, heavy menstrual bleeding, purpura, too few platelets circulating in the blood, and prolonged bleeding time have also been listed as symptoms of various giant platelet [en.wikipedia.org]

Platelet Dysfunction in Uremia Abnormal bleeding is common in patients with uremia. Bleeding time is generally very prolonged. [emedicine.medscape.com]

Platelet-Type Bleeding Disorder 17

Bleeding time was prolonged on most occasions. [ncbi.nlm.nih.gov]

Lab Diagnosis: Low platelet count + Blood smear showing large grey hypogranular platelets the bleeding time is prolonged also Genetic Testing performed Electron Microscopy [medical-labs.net]

It is associated with thrombocytopenia, enlarged platelets, and prolonged bleeding time. [icd10data.com]

Congenital Alpha-2-Antiplasmin Deficiency

It is associated with THROMBOCYTOPENIA, enlarged platelets, and prolonged bleeding time. [bioportfolio.com]

[…] disease -prolonged PTT, bleeding time, rest unaffected 5.DIC: -prolonged PT, PTT, bleeding time -low platelet counts [quizlet.com]

Glycoprotein 6 Deficiency

Fonti utilizzate nella revisione corrente Movva, S. et. al. (2018 September 30, Updated). Antiphospholipid Syndrome. Medscape Rheumatology. Available online at https://emedicine.medscape.com/article/333221-overview. Accessed October 2019. Berg, T. (2017 January 17, Updated). Antiphospholipid Syndrome and Pregnancy.[…] [labtestsonline.it]

Autosomal Dominant Wiskott-Aldrich Syndrome

Acquired Von Willebrand Syndrome

RIPA was greater than 1.8 mg/ml, and bleeding time (BT) was prolonged (18 min). No evidence for an in vitro inhibitor against the VIII/vWF complex was observed. [ncbi.nlm.nih.gov]

Following infusion of DDAVP (0.3-0.4 micrograms/kg), prolonged bleeding time was normalized; plasma ristocetin cofactor activity, von Willebrand factor antigen, and factor [ncbi.nlm.nih.gov]

bleeding time and low plasma levels of factor VIII - von Willebrand factor (vWF) measurements. [ncbi.nlm.nih.gov]

Acquired Hemophilia

Diagnosis should be considered if there is abnormal bleeding and a prolonged activated partial thromboplastin time (aPTT). [hemophilianewstoday.com]

Acquired hemophilia A (AHA) should be suspected in patients with a new onset of bleeding and an isolated prolongation of activated partial thromboplastin time. [ncbi.nlm.nih.gov]

[…] partial thromboplastin time (APTT) and other common causes of a prolonged APTT are ruled out. [ncbi.nlm.nih.gov]

Retinal Vascular Occlusion

ACUVAIL solution should be used with caution in patients with known bleeding tendencies or who are receiving other medications, which may prolong bleeding time. [allerganeyecare.com]

Retinal Vein Occlusion

ACUVAIL solution should be used with caution in patients with known bleeding tendencies or who are receiving other medications, which may prolong bleeding time. [allerganeyecare.com]

Prekallikrein Deficiency

Bleeding disorders associated with coagulopathy O bleeding platelet count, bleeding time, capillary fragility test: normal PT, aPTT: prolonged -> coagulation factor, fibrinogen [slideplayer.com]

bleeding more common with factor XI, lab results include prolonged APTT, normal PT, TT, bleeding time, prolonged incubation with activating factor kaolin will normalized [quizlet.com]

[…] the bleeding time. 16,18 Coagulation factor deficiencies commonly do not prolong the bleeding time. vWD often is associated with a prolonged bleeding time, a normal platelet [ahcmedia.com]

Carbon Monoxide -- Teratogenic Agent

Aspirin-indomethacin Prostaglandin synthesis inhibitors Increase in gestation time prolong labor, neonatal bleeding Risk of postpartum hemorrhage CNS depressants e.g. diazepam [slideplayer.com]

[…] prematurely), pulmonary hypertension in newborns Benzodiazepines as Diazepam Chronic use → neonatal dependence and withdrawal symptoms ACEIs Renal damage warfarin Risk of bleeding [slideplayer.com]

Platelet-Type Bleeding Disorder 12

time prolonged in platelet disorders? [quizlet.com]

Bleeding time is prolonged with both Thrombocytopenia and giant platelets. [helena-biosciences.com]

The bleeding time is prolonged in only a few patients, and hemorrhage can occur in patients with a normal bleeding time. [doctorlib.info]

Hereditary Factor I Deficiency

bleeding; 3) Baltimore: major defect, fibrinopeptide release; thrombin time prolonged; no inhibitory effect on normal clotting; bleeding and thrombosis; 4) Leuven: major [medical-dictionary.thefreedictionary.com]

Unlike the thrombin time, Reptilase® time is not prolonged by heparin or hirudin. [mghlabtest.partners.org]

Glycoprotein 1A Deficiency

Bleeding time was prolonged in 5 investigated patients. [ncbi.nlm.nih.gov]

It is associated with thrombocytopenia, enlarged platelets, and prolonged bleeding time. [icd10data.com]

We conclude that the bleeding disorder and excessively prolonged bleeding time in our patient are caused by a new specific defect of the platelet-vessel wall interaction. [bloodjournal.org]