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62 Possible Causes for Block of B Cell Differentiation

  • Anemia

    […] of the transferrin receptor by alfa1-antitrypsin (an acute phase protein) negatively affect the biological functions of EPO along with cell growth and differentiation[ 1[] Other types of anemia Vitamin B 12 deficiency has been observed in 48% of CD patients and in 5% of UC patients[ 31 ] while folic acid deficiency has been noted in 67% of CD[] […] availability of iron for heme biosynthesis induced by “functional” or “absolute’’ iron deficiency and the inhibition of iron uptake into erythroid progenitors due to the blocking[]

  • Osteoporosis

    cells, which activates the differentiation of osteoclasts and maintains their function.[] Osteoblasts also produce and secrete osteoprotegerin (OPG), a decoy receptor that can block RANKL/RANK interactions.[] Three members of the TNF and TNF receptor superfamily are involved (Figure 2 ); osteoblasts produce RANKL, a ligand for the receptor activator of NF- B (RANK) on hematopoietic[]

  • Infectious Mononucleosis

    Expression of C3d receptors during human B-cell differentiation: immunofluorescence analysis with the HB-5 monoclonal antibody. J. Immunol. 133 : 678 -683. Turk, S.[] Soluble gp350/220 and deletion mutant glycoproteins block Epstein-Barr virus adsorption to lymphocytes. J. Virol. 62 : 4452 -4464. Tedder, T. F., L. T. Clement, and M.[]

  • Prostate Sarcoma

    Immunohistochemical findings A properly controlled immunostain panel was performed on the cell block to determine the nature of the tumor.[] Differential diagnosis of this spindle cell tumor includes SSCC, malignant spindle cell melanoma, MSFT, ACT, metastatic FS, MPNST, PNET/ES, and LMS.[] The cells had a fascicular arrangement with focal storiform pattern with no glandular architectures were identified [Figure 2] a, [Figure 2] b, [Figure 2] g and [Figure 2][]

  • Rhabdomyosarcoma

    Zhu B, Zhang M, Byrum SD, Tackett AJ, Davie JK (2014) TBX2 blocks myogenesis and promotes proliferation in rhabdomyosarcoma cells. Int J Cancer 135 : 785–797.[] Zhang M, Truscott J, Davie J (2013) Loss of MEF2D expression inhibits differentiation and contributes to oncogenesis in rhabdomyosarcoma cells. Mol Cancer 12 : 150.[]

  • Malignant Ascites

    Maguire B, Whitaker D, Carrello S, Spagnolo D Monoclonal antibody Ber-EP4: its use in the differential diagnosis of malignant mesothelioma and carcinoma in cell blocks of[]

  • Primary Immune Deficiency Disorder

    […] in T-cell differentiation) [ 14 ].[] B-cell immunodeficiencies The mainstay of therapy for most B-cell (antibody-deficiency) disorders is intravenous (IV) or subcutaneous Ig replacement therapy; in fact, many[] […] reconstitution and improved survival in patients with certain SCIDs, such as adenosine deaminase (ADA) deficiency and SCID-X1 (an X-linked inherited SCID characterized by an early block[]

  • Diffuse Large B-Cell Lymphoma

    […] lymphoma subtype probably arises from normal germinal-center B cells, whereas the activated B-cell–like subtype may arise from a post-germinal-center B cell that is blocked[] […] during plasmacytic differentiation.[] Many oncogenic mechanisms distinguish these subtypes: germinal-center B-cell–like diffuse large-B-cell lymphomas have recurrent t(14;18) translocations, whereas activated[]

  • Gastric Carcinoma

    SPEN can block the precursor B cells differentiating into marginal zone B cells and also repress the transcription via the recruitment of large complexes that contain histone[]

  • Systemic Lupus Erythematosus

    […] binding of BLyS to receptors on B cells, inhibiting survival of B cells, and reducing B-cell differentiation into immunoglobulin-producing plasma cells Belimumab IV 10 mg[] […] infertility, increased risk of infection and cancer Baseline and routine CBC, platelet count, SCr, LFTs, and urinalysis (depends on individual drug) Monoclonal antibodies Block[]

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