Blonde Hair: Causes & Reasons

Possible Causes for Blonde Hair

Fair hair which is often blond, but also dark blond and black hair. Skin type 3 – Sometimes red but always tans after a while. Skin type 4 – Never burns. [oncolex.org]

Race: People with fair skin, freckling or red or blond hair have a higher risk. [idph.state.il.us]

hair; and a family history of unusual moles or melanoma. [livescience.com]

Squamous Cell Carcinoma of the Skin

People at the highest risk for developing basal cell carcinoma have fair skin, red or blond hair, and green, blue, or gray eyes. [nyulangone.org]

Individuals with light-colored skin, freckled skin, blond hair, red hair, and light eyes have a greater risk for skin cancer. [innerbody.com]

Certain things can increase your chances of developing melanoma, such as having: lots of moles or freckles pale skin that burns easily red or blonde hair a close family member [www2.hse.ie]

Classical Phenylketonuria

In addition to congenital anomalies and developmental delay, blond hair, fair skin and unusual urinary odor were noted. [ncbi.nlm.nih.gov]

This may explain why persons with phenylketonuria generally have blond hair, blue eyes, and fair skin. [britannica.com]

[…] retention of phenylalanine in other tissues also leads to a decrease in the formation of melanin, a product of tyrosine metabolism that produces the pigment found in the skin, hair [britannica.com]

Homocystinuria

The hereditary form features sparse blond hair, OSTEOPOROSIS with overgrowth of long bones, a hollowed chest, dislocation of the lenses of the eyes and mental retardation. [medical-dictionary.thefreedictionary.com]

Clinical features include a tall slender habitus, SCOLIOSIS, arachnodactyly, MUSCLE WEAKNESS, genu varus, thin blond hair, malar flush, lens dislocations, an increased incidence [fpnotebook.com]

Clinical features include a tall slender habitus, scoliosis, arachnodactyly, muscle weakness, genu varus, thin blond hair, malar flush, lens dislocations, an increased incidence [icd10data.com]

Prader-Willi Syndrome

[…] have fair skin, blonde hair and blue eyes, regardless of what their family members look like), and a turned-down mouth ( Better Health Channel ). [hwns.com.au]

Around half of all children with Prader-Willi syndrome will have fair skin, blonde hair and blue eyes, regardless of what their family members look like.Children with Prader-Willi [betterhealth.vic.gov.au]

[…] have fair skin, blonde hair and blue eyes, regardless of what their family members look like), and a turned-down mouth (Better Health Channel). [aruma.com.au]

Phenylketonuria

This may explain why persons with phenylketonuria generally have blond hair, blue eyes, and fair skin. [britannica.com]

[…] development Mental retardation Seizures Very dry skin, eczema, and rashes Distinctive “mousy” or “musty” odor of the urine, breath, and sweat Light complexion, light or blonde [rarediseases.about.com]

As a result, children with PKU often will have pale skin, blond hair and blue eyes. [drugs.com]

Cartilage Hair Hypoplasia

It is a multi-systemic disorder characterized by short stature, blond fine sparse hair, but this may be quite variable, and defective cellular immunity predominantly affecting [atlasgeneticsoncology.org]

CHH is an autosomal recessive disorder characterized by skeletal involvement, short stature, variable features like blond fine sparse hair, and defective cellular immunity [karger.com]

Originally, the syndrome was believed to be characterized by unevenly short arms and legs (short limbed dwarfism), fine and light-colored hair (hypotrichosis), low levels [rarediseases.org]

Hermansky-Pudlak Syndrome Type 2

Blond hair Fair hair color Flaxen hair color Light colored hair Sandy hair color Straw colored hair Towhead (hair color) [ more ] 0002286 Gastroesophageal reflux Acid reflux [rarediseases.info.nih.gov]

Chronic oral candidiasis Chronic oral thrush 0009098 Coarse facial features Coarse facial appearance 0000280 Epicanthus Eye folds Prominent eye folds [ more ] 0000286 Fair hair [rarediseases.info.nih.gov]

ADULT Syndrome

Born with blonde hair and blue eyes at 7 lbs, 5 ounces, Chris was a happy baby. [advocategiving.org]

Blonde Thin scalp hair Sparse underarm (axillary) hair Reported premature scalp hair loss (>30 years) Diagnosing ADULT Syndrome A physician can diagnose ADULT on the basis [nfed.org]

All affected individuals have very blond, thin and sparse hair. Nails are reported to be dysplastic, and one or several teeth were lacking. [nature.com]

Histidinemia

[…] journal of diseases of children 1967 The emerging clinical picture, when symptomatology is present, consists of a speech defect, mental retardation of mild to moderate degree, light-colored [semanticscholar.org]

The emerging clinical picture, when symptomatology is present, consists of a speech defect, mental retardation of mild to moderate degree, light-colored hair and eyes, and [jamanetwork.com]

hair and eyes, and, possibly, growth retardation. [semanticscholar.org]

Actinic Keratosis

People with blonde or red hair, blue eyes, and skin type I or II are particularly susceptible (see Table: Fitzpatrick Skin Type Classification). [msdmanuals.com]

People with blonde or red hair are especially susceptible to the short-term and long-term effects of UV radiation, because they are not able to produce enough melanin. [merckmanuals.com]

Fitzpatrick Skin Type Classification Skin Type Typical Features Tanning Ability I Pale white skin; red or blond hair; blue/green eyes; freckles Always burns, never tans II [msdmanuals.com]

Acute Hepatic Porphyria

April 09, 2019; 92 (15 Supplement) May 7, 2019, Sean R. Rudnick, Madeline Merkel, John J. Ko, Barbara H. Johnson, Virginia Noxon, Ashley L. Cole, Sonalee Agarwal First published April 16, 2019, Abstract Objective: This study’s objective was to follow AHP/AIP patients’ healthcare journeys from first suspected symptom to[…] [n.neurology.org]

Acute Intermittent Porphyria

Acute intermittent porphyria is a hereditary disorder characterized by deficient activity of the enzyme porphobilinogen deaminase. It manifests with occasional neurovisceral crises due to overproduction of porphyrin precursors. We report a 12 year old male child with acute intermittent porphyria, who presented with[…] [ncbi.nlm.nih.gov]

HAIR-AN Syndrome

Examination revealed thin blonde hair extending to the nape of the neck. [jpeds.com]

Uncombable hair syndrome most often occurs in Caucasians and only affects people with blond or light-colored hair, Nino said. [insider.com]

Affected children have extremely frizzy, dry, generally light blonde hair, with a characteristic shine. [express.co.uk]

Delta Aminolevulinate Dehydrase Deficiency

J.H.P. Wilson, A. Edixhoven, R. Koole, F.W.M. de Rooij Erasmus MC, Rotterdam, The Netherlands Background: We have developed an enzymatic assay for plasma aminolevulinic acid (ALA) and porphobilinogen (PBG), which is a more sensitive test for acute intermittent porphyria (AIP) than urine ALA and PBG analysis. Plasma[…] [porphyria.eu]

Superficial Spreading Melanoma

Certain things can increase your chance of developing melanoma, such as having: lots of moles or freckles pale skin that burns easily red or blonde hair a close family member [nhs.uk]

Certain things can increase your chances of developing melanoma, such as having: lots of moles or freckles pale skin that burns easily red or blonde hair a close family member [www2.hse.ie]

You are more likely to develop melanoma if you: Have fair skin, blue or green eyes, or red or blond hair Live in sunny climates or at high altitudes Spent a lot of time in [medlineplus.gov]

Smith Lemli Opitz Syndrome

Smith-Lemli-Opitz syndrome Description, Causes and Risk Factors: ICD-9-CM: 759.89. Abbreviation: SLOS. Mental retardation, small stature, anteverted nostrils, ptosis, male genital anomalies, and syndactyly of the second and third toes, often in breech-born babies with delayed fetal activity; inherited as an autosomal[…] [medigoo.com]

Hyperphenylalaninemia

Homepage Rare diseases Search Search for a rare disease Hyperphenylalaninemia due to tetrahydrobiopterin deficiency Disease definition Hyperphenylalaninemia (HPA) due to tetrahydrobiopterin (BH4) deficiency, also known as malignant HPA is an amino acid disorder with neonatal onset that is clinically characterized by[…] [orpha.net]

Oculocutaneous Albinism

hair. [ncbi.nlm.nih.gov]

Interestingly, the patient also had very light skin color, blond hair and eyebrows, and dark brown eyelashes and irises. [ncbi.nlm.nih.gov]

Individuals at birth may be misdiagnosed as OCA type I but it is common for pigmentation to increase in older individuals resulting in yellow or reddish-blond hair and the [disorders.eyes.arizona.edu]

Oculocutaneous Albinism, Type 2

The majority of affected individuals develop some cutaneous melanin; this is predominantly seen as yellow/blond hair, whereas fewer have brown hair. [ncbi.nlm.nih.gov]

Their hair are usually pale blonde to golden or reddish-blonde hair. Having blue eyes is one of their common characteristics. [medigest.uk]

Symptoms - Oculocutaneous albinism type 2 * Creamy white skin * Light yellow hair * Blond hair * Light brown hair * Light-colored irises Causes - Oculocutaneous albinism type [checkorphan.org]

Oculocutaneous Albinism Type 6

Moreover, the African is not black, but an albino with blonde hair and white skin. [derm101.com]

[…] or even brown hair, and most commonly blue eyes. [en.wikipedia.org]

A little pigment can develop in freckles or moles. [6] People with OCA2 usually have fair skin but often not as pale as OCA1, and pale blonde to golden, strawberry blonde, [ipfs.io]

Oculocerebral Hypopigmentation Syndrome Type Cross

hair with yellow-gray metallic sheen, small eyes with cloudy corneas, jerky nystagmus, gingival fibromatosis and severe menta... [encyclo.co.uk]

" Cross syndrome ", " hypopigmentation and microphthalmia ", and " oculocerebral-hypopigmentation syndrome ") is an extremely rare disorder characterized by white skin, blond [en.wikipediam.org]

hair with yellow-gray metallic sheen HEENT Microcephaly Small eyes with cloudy corneas Gingival fibromatosis Neurologic Mental retardation - decreased intellectual capacity [wikidoc.org]

X-Linked Recessive Ocular Albinism

He has ruddy white skin, blond hair, and blue eyes (the default colours when no pigment is present). [whitemail.blogspot.com]

The spectrum of hair pigmentation is from very >fair hair to brown hair, red hair is possible as well, although most of >them have blonde hair. [nystagmus.org]

He has blond hair and light-colored eyes. He is an only child and according to the parents, there does not seem to be a family history of this condition. [reviewofoptometry.com]

Ringed Hair Disease

Usually this hair defect is most obvious in people with blond hair as dark hair obscures the light and dark band pattern. [keratin.com]

Pseudo pili annulati is most obvious in people with blond hair. It can present as natural highlights in limited areas on the scalp. [keratin.com]

but other regions such as pubic, axillary, and beard hair, may also be affected.[3][10] Pili annulati is easily detected in blonde hair while it can be completely obscured [ncbi.nlm.nih.gov]

Familial Melanoma of the Eyelid

People with fair skin that freckles or burns easily, people with blue, green or light-colored eyes, and those with red or blond hair are all at increased risk. [curetoday.com]

Certain things can increase your chances of developing melanoma, such as having: lots of moles or freckles pale skin that burns easily red or blonde hair a close family member [nhs.uk]

Whites with red or blond hair, blue or green eyes, or fair skin that freckles or burns easily are at increased risk. [cancer.org]

Uncombable Hair Syndrome

Four children had short, unmanageable, pale blond hair. They had no associated abnormalities and no family histories of abnormal hair. [ncbi.nlm.nih.gov]

We report a family affected to the fourth generation by uncombable hair syndrome. This syndrome is characterized by unruly, dry, blond hair with a tangled appearance. [ncbi.nlm.nih.gov]

[…] uncombable hair syndrome [MIM*191480] a genetic syndrome in which the hair, which is often silvery blond, is unruly and resists lying flat because of irregularly shaped hair [medical-dictionary.thefreedictionary.com]

Pili Torti

[…] the isolated finding of twisted hairs in two young blond-haired sisters.2 Since then, pili torti has been linked with a wide array of congenital defects, including leukonychia [ncbi.nlm.nih.gov]

[…] the isolated finding of twisted hairs in two young blond-haired sisters. 2 Since then, pili torti has been linked with a wide array of congenital defects, including leukonychia [ncbi.nlm.nih.gov]

Each twist is 0.4-0.9 mm wide and occurs in groups of 3 to 10.3,7 The twisted hair is fragile and easily brittle on the scalp.4 Blond hair tends to be scarce, opaque, lusterless [ncbi.nlm.nih.gov]

Digestive System Melanoma

Other risk factors include UV exposure (sunlight or tanning booths), history of blistering sunburns, dysplastic nevi, large numbers of ordinary moles, red or blonde hair, [dermspecpa.com]

hair Light-colored eyes Caucasian race Family members with melanoma Excessive skin exposure to the sun without protective clothing or sunscreen Suppressed immune system Symptoms [uvahealth.com]

hair Light-colored eyes Family members with melanoma Excessive skin exposure to the sun without protective clothing or sunscreen Certain occupations, such as telephone repair [winchesterhospital.org]

Albinism

Some patients with albinism have white hair and very light blue eyes, others have blonde hair and blue eyes, and some even have brown hair and eyes. [aapos.org]

Symptoms of albinism Hair and skin colour People with albinism often have white or very light blonde hair, although some have brown or ginger hair. [nhs.uk]

Most children with albinism are born to parents who have normal hair and eye color for their ethnic backgrounds. [aapos.org]

Woolly Hair Nevus

It is clinically characterized by spun-glass, silvery-blonde hair. [yumpu.com]

Patients affected with this condition present two distinct hair populations: straight, blond or brown, long hair shafts interspaced with short, fine, hypopigmented and curly [miami.pure.elsevier.com]

[…] autosomal dominant trait or a sporadic structural hair abnormality. [2] Clinically, the hair is dry, coarse, usually blond to light brown with a tangled appearance. [ijdvl.com]