Blue Eyes: Causes & Reasons

Possible Causes for Blue Eyes

Summary Two Japanese siblings, a 2-year-old girl and a 7-month-old boy, had a syndrome of mental retardation, severe nasal hypoplasia, peripheral dysostosis, and blue eyes [link.springer.com]

[…] irides Blue eyes 0000635 Broad nasal tip Broad tip of nose Broad, upturned nose Increased breadth of nasal tip Increased breadth of tip of nose Increased width of nasal tip [rarediseases.info.nih.gov]

[…] also been reported in some people living with acrodysostosis: repeated middle ear infections; hearing loss; obesity; skin lesions that are flesh-coloured, brown or black; blue [acrodysostosis.org]

Albinism

This means they often have very pale skin, very light hair and either blue or grey eyes. [thesun.co.uk]

For example the 'Brown Eye Gene' is Dominant and the 'Blue Eye Gene' is Recessive. [ssc.education.ed.ac.uk]

Alamy Albinism sufferers usually have very pale skin, pale hair and blue eyes Due to their pale skin, it puts them at a greater risk of skin problems such as sunburn and skin [thesun.co.uk]

Klein-Waardenburg Syndrome

People with this condition often have very pale blue eyes or different colored eyes, such as one blue eye and one brown eye. [hon.ch]

Eye Colors Colours Blue Eyes Image People Search Birth Laser Surgery Beautiful Eyes Forward But a small percentage of us are quirkier than the rest. [pinterest.de]

Waardenburg syndrome is a group of genetic conditions that can cause hearing loss and changes in coloring (pigmentation) of the hair, skin, and eyes. [hon.ch]

Oculocutaneous Albinism, Type 2

1, blue/nonblue eyes or skin/hair/eye pigmentation type 1, blue/brown eyes or skin/hair/eye pigmentation type 1, blond/brown hair or eye color, brown/blue or eye color, blue [uniprot.org]

Another mutation in the OCA2 is found common to nearly all people with blue eyes, and has been hypothesized that all blue eyed humans share a single common ancestor with whom [cloud-clone.com]

Having blue eyes is one of their common characteristics. Those with African descent usually have yellow hair, pale skin, and blue, gray, or hazel eyes. [medigest.uk]

Oculocutaneous Albinism Type 6

Affected people of African descent usually have a different phenotype (appearance): yellow hair, pale skin, and blue, gray or hazel eyes. [en.wikipedia.org]

Affected individuals typically have red hair, reddish-brown skin and blue or gray eyes. [ipfs.io]

Kayser M. et.al. 18252221 [25] “A single SNP in an evolutionary conserved region within intron 86 of the HERC2 gene determines human blue-brown eye color.” [tcdb.org]

X-Linked Recessive Ocular Albinism

My dad, blonde hair, fair skin, blue eyes. I have one sister, dark hair, fair skin, blue eyes (without CN). I am pregnant with my first child and wondering "what if". [nystagmus.org]

He has ruddy white skin, blond hair, and blue eyes (the default colours when no pigment is present). [whitemail.blogspot.com]

Most people with ocular albinism have blue eyes. But the blood vessels inside can show through the colored part (the iris), and the eyes can look pink or red. [webmd.com]

Ocular Albinism

Light blue eyes may suggest the diagnosis in families in which the disorder is known to occur, but blue eyes are not uncommon in the general population. [disorders.eyes.arizona.edu]

Affected individuals usually have blue eyes with skin and hair color similar to that which would be expected of a non-affected individual with a similar genetic background [wiki.ggc.usg.edu]

In these disorders, the pigmentation in the eyes is also affected, most noticeably in the iris which is usually pale blue. [disorders.eyes.arizona.edu]

Blue Sclera

MAR 13, 2013 Question: My son is two months old and was born with brown eyes. Now the ring around his eyes and the white part of his eyes is blue. Is this normal? [aao.org]

Generally not: Brown eyes dominate over blue. [healthtap.com]

Anyone else have a baby with blue eyes? This is page 1 of 1 (This thread has 6 messages.) [mumsnet.com]

Heat Ray Cataract

[…] your eyes from blue light. [allaboutvision.com]

Blue light rays (400 nm to 470 nm) are adjacent to the invisible band of UV light rays: • There is increasing evidence that blue light is harmful to the eye and can amplify [discoveryeye.org]

Use of vitamin supplements and cataract: the Blue Mountains Eye Study. Am J Ophthalmol 2001;132:19-26. 12. Jacques PF, Taylor A, et al. [passeportsante.net]

Osteogenesis Imperfecta Type 2

The classic symptoms include: Blue tint to the whites of their eyes (blue sclera) Multiple bone fractures Early hearing loss ( deafness ) Because type I collagen is also found [medlineplus.gov]

The disease is characterized by short limb dwarfism, thin skin, soft skull, unusually large fontanels (soft spots), blue sclerae (whites of the eyes, small nose, low nasal [rxlist.com]

A physical exam may show that the whites of their eyes have a blue tint. A definitive diagnosis may be made using a skin punch biopsy. [medlineplus.gov]

Actinic Keratosis

People with blonde or red hair, blue eyes, and skin type I or II are particularly susceptible (see Table: Fitzpatrick Skin Type Classification). [msdmanuals.com]

You have a higher risk of developing this condition if you: are over age 60 have light-colored skin and blue eyes have a tendency to sunburn easily have a history of sunburns [healthline.com]

Fitzpatrick Skin Type Classification Skin Type Typical Features Tanning Ability I Pale white skin; red or blond hair; blue/green eyes; freckles Always burns, never tans II [msdmanuals.com]

Malignant Choroidal Melanoma

There is no known cause, though incidence is highest among people with lighter skin and blue eyes. [ocularmelanoma.org]

Risk factors Risk factors for primary melanoma of the eye include: Light eye color. People with blue eyes or green eyes have a greater risk of melanoma of the eye. [mayoclinic.org]

There is a higher incidence of choroidal melanoma in people with blue eyes and people that work outdoors. [mastereyeassociates.com]

Keratoglobus

Three patients (3 eyes) had blue sclera, joint hypermobility, and consanguineous parents; 3 other patients (4 eyes) had only KGB. [ncbi.nlm.nih.gov]

8/22 eyes (36.37%) without blue sclera. [ncbi.nlm.nih.gov]

Conclusions: About 50% of pediatric eyes (65% having blue sclera) had no functional vision. [doaj.org]

Asteroid Hyalosis

METHODS: The Blue Mountains Eye Study was a cross-sectional study of an older community (aged 49-97 years). [ncbi.nlm.nih.gov]

Beaver Dam Eye Study.[5] The estimate prevalence of AH in Seoul, Korea is 0.36%.[6] The Blue Mountains Eye Study also found no evidence to support earlier observation of a [eyewiki.aao.org]

Eye (Lond), 2008. 22(10): p. 1318-29. 5. Mitchell, P., M.Y. Wang, and J.J. Wang, Asteroid hyalosis in an older population: the Blue Mountains Eye Study. [eyewiki.aao.org]

Acrodysostosis

Of eight Japanese patients reported, four had abnormal eye color: a 7-month-old boy with blue irides and his 2-year-old elder sister with light-blue eyes a 6-year-old girl [ncbi.nlm.nih.gov]

[…] with gray-brownish irides, and a 4-year-old girl (present case) with blue-brownish irides. [ncbi.nlm.nih.gov]

Iris Melanoma

However, uveal melanoma is more common in those who are fair skinned and have grey/blue eyes. The average age at which an ocular melanoma develops is 55-60. [moorfields.nhs.uk]

There is no known cause, though incidence is highest among people with lighter skin and blue eyes. [ocularmelanoma.org]

“The presence of iris freckling and naevi (moles), provides additional information about an individual’s melanoma risk over and above factors like blue eyes, red hair, fair [uq.edu.au]

Osteogenesis Imperfecta

eye sclera. [ncbi.nlm.nih.gov]

Many subjects with OI have a characteristic blue tint to the whites of their eyes (blue sclerae). [bonehealth.wustl.edu]

The classic symptoms include: Blue tint to the whites of their eyes (blue sclera) Multiple bone fractures Early hearing loss ( deafness ) Because type I collagen is also found [medlineplus.gov]

Iris Disorder

Two genes control eye color: EYCL3, found on chromosome 15, which codes for brown/blue eye color (BEY), and EYCL1, found on chromosome 19, which codes for green/blue eye color [scientificamerican.com]

New research shows that people with blue eyes have a single, common ancestor. [sciencedaily.com]

Brown eyes have large amounts of melanin pigment deposits, and blue eyes have a lack of melanin. [medicinenet.com]

Osteogenesis Imperfecta Type 3

The classic symptoms include: Blue tint to the whites of their eyes (blue sclera) Multiple bone fractures Early hearing loss ( deafness ) Because type I collagen is also found [medlineplus.gov]

A physical examination may show that the whites of their eyes have a blue tint. [focusondisability.org.uk]

usually have a blue, purple, or gray tint Triangular face Tendency toward spinal curvature Bone deformity absent or minimal Brittle teeth possible Hearing loss possible, [bones.emedtv.com]

Tritanopia

[G. tritos, third, + an- priv. + ōps, eye] tritanopia Unable to appreciate the colour blue. [medical-dictionary.thefreedictionary.com]

Read More In human eye: Colour defectiveness Tritanopes (people with blue blindness) are rare, constituting only 1 in 13,000 to 65,000 of the population. [britannica.com]

Circadian rhythms are regulated by melanopsin, a molecule in the eye that captures blue light. [digitalcommons.butler.edu]

Tietz Syndrome

Clinical description Affected cases have a pale skin, blue eyes and light blond to white hair with white eyebrows and eyelashes. [orpha.net]

People with Tietz syndrome are born with white hair and very pale skin but their hair color often darkens over time; The colored part of the eye (the iris) is blue. [1] [2 [rarediseases.info.nih.gov]

The iris in affected individuals is blue, and specialized cells in the eye called retinal pigment epithelial cells lack their normal pigment. [en.wikipedia.org]

Oculocutaneous Albinism

Another mutation in the OCA2 is found common to nearly all people with blue eyes, and has been hypothesized that all blue eyed humans share a single common ancestor with whom [cloud-clone.com]

eyes pink-red nevi solar keratosis ocular impaired visual acuity nystagmus strabismus type 2 (less severe) pink to cream skin color yellow/brown hair (not white hair) blue [medbullets.com]

Such individuals have blond hair, blue eyes, and pigmented nevi (Figure 3). [clinicaladvisor.com]

Fuchs Heterochromic Iridocyclitis

Kate Bosworth The actress arguably best known for Blue Crush has one blue eye and one eye that’s blue and hazel. 3. [mentalfloss.com]

Don’t it make my blue eyes brown: heterochromia and other abnormalities of the iris. Rennie IG. Eye:2012:26:1:29-50. 3. [neuro-ophthalmology.stanford.edu]

A person might have one green eye and one blue eye, or a brown eye and a blue eye. Complete heterochromia is also common in animals, such as cats. [disabled-world.com]

Neoplasm of the Eye

There is no known cause, though incidence is highest among people with lighter skin and blue eyes. [ocularmelanoma.org]

Finger believes that since skin and conjunctival melanomas have been linked to ultraviolet exposure, and since choroidal melanomas are more commonly found in patients with blue [eyecancer.com]

People who have fair-skin and blue eyes are most affected. An eye examination with an ophthalmoscope may reveal a single round or oval lump (tumor) in the eye. [medlineplus.gov]

Brittle Cornea Syndrome Type 2

[…] appearing sclera (eyes) and severe muscle weakness. [checkorphan.org]

Other eye symptoms may include nearsightedness ( myopia ), a blueish tint in the white part of the eyes (blue sclera), and retinal detachment. [rarediseases.info.nih.gov]

[…] affects the eyes, joints and skin. [diseaseinfosearch.org]

Classical Phenylketonuria

This may explain why persons with phenylketonuria generally have blond hair, blue eyes, and fair skin. [britannica.com]

eyes, because phenylalanine can't transform into melanin — the pigment responsible for hair and skin tone Abnormally small head (microcephaly) Hyperactivity Intellectual [mayoclinic.org]

eyes. [gesundheitsindustrie-bw.de]

Brittle Cornea Syndrome Type 1

Other eye symptoms may include nearsightedness ( myopia ), a blueish tint in the white part of the eyes (blue sclera), and retinal detachment. [rarediseases.info.nih.gov]

[…] cornea after only minor trauma; degeneration of the cornea ( keratoconus ) or thinning and protrusion of the cornea (keratoglobus); bluish tint in the white part of the eyes [rarediseases.info.nih.gov]

[…] affects the eyes, joints and skin. [diseaseinfosearch.org]

Age-Related Macular Degeneration Type 5

Risk of age-related macular degeneration in eyes with macular drusen or hyperpigmentation: the Blue Mountains Eye Study cohort. Arch Ophthalmol. 2003;121:658–663. [ncbi.nlm.nih.gov]

Statins and the long-term risk of incident age-related macular degeneration: the Blue Mountains Eye Study. Am J Ophthalmol. 2007;143:685–687. [ncbi.nlm.nih.gov]

Retinal vessel wall signs and the 5 year incidence of age related maculopathy: the Blue Mountains Eye Study. Br J Ophthalmol. 2004;88:104–109. [ncbi.nlm.nih.gov]

Thinking Seizures

eyes Flicker Until life Leaped away My souls as strained as the scene of the crime Cut her for days but I kept her alive 400 volts Electricity Trying to purge me Cleansing [letras.com]

[…] mouth to scream a whisper in this ghost town Trying to swallow tongue to end this horror Induced seizures don't stop lust for gore Dark red Sundress Bleached skin Lifeless Blue [letras.com]

Age-Related Macular Degeneration 10

Risk of age-related macular degeneration in eyes with macular drusen or hyperpigmentation: the Blue Mountains Eye Study cohort. Arch Ophthalmol. 2003;121:658–663. [ncbi.nlm.nih.gov]

Statins and the long-term risk of incident age-related macular degeneration: the Blue Mountains Eye Study. Am J Ophthalmol. 2007;143:685–687. [ncbi.nlm.nih.gov]

Retinal vessel wall signs and the 5 year incidence of age related maculopathy: the Blue Mountains Eye Study. Br J Ophthalmol. 2004;88:104–109. [ncbi.nlm.nih.gov]