Bluish-Red Border Demarcating Transition to Normal Skin & Vitiligo: Causes & Reasons

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Patient File

Sex unknown, Age unknown

Reported Symptoms

Bluish-Red Border Demarcating Transition to Normal Skin, Vitiligo,

Negated

None

Unsure

None

Possible Causes

Alopecia Areata

Vitiligo and alopecia areata are common autoimmune diseases of the skin. [ncbi.nlm.nih.gov]

Vitiligo and alopecia areata are two cutaneous diseases believed to be primarily autoimmune in pathogenesis. [ncbi.nlm.nih.gov]

Herein, we report an 8-year-old boy who had colocalization of alopecia areata and vitiligo on the frontal portion of his scalp. [ncbi.nlm.nih.gov]

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Pernicious Anemia

The case presented here is a woman who had a restoration of fertility after initiation of vitamin B12 treatment for vitiligo-associated pernicious anemia. [ncbi.nlm.nih.gov]

Vitiligo is an acquired disease characterized by depigmentation of the skin due to destruction of melanocytes. [ncbi.nlm.nih.gov]

A patient with a 46-year history of vitiligo who also presented rheumatoid arthritis and pernicious anemia is described. [ncbi.nlm.nih.gov]

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Addison Disease

Patient with Addison’s disease on a background of vitiligo (face). Figure 2. Patient with Addison’s disease on a background of vitiligo (hands). [bjgp.org]

These include: Vitiligo The skin condition vitiligo can also appear simultaneously with idiopathic autoimmune Addison's disease. [news-medical.net]

One such patient presented in Autumn 2013 (see Figures 1 and 2 demonstrating vitiligo of the face and hands). [bjgp.org]

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Vitiligo

Some people with vitiligo also have patches of pigment loss affecting the hair on their scalp or body. Researchers have identified several forms of vitiligo. [ghr.nlm.nih.gov]

Genetics of vitiligo Vitiligo is characterized by partial penetrance, many sensitive areas, and genetic heterogeneity. [symptoma.com]

vitiligo. [niams.nih.gov]

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Uveomeningoencephalitic Syndrome

Cytokines: the yin and yang of vitiligo pathogenesis. [bioportfolio.com]

Uveomeningoencephalitic Syndrome yourself 0 0 A Syndrome characterized by bilateral granulomatous Uveitis with Iritis and secondary Glaucoma, premature Alopecia, symmetrical Vitiligo [dictionary.university]

Steroid ointment was unsuccessful against the vitiligo. [kyushu-u.pure.elsevier.com]

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Rothmund Thomson Syndrome

Idiopathic Guttate Hypomelanosis Laugier-Hunziker Syndrome Lentigo Melasma Ocular Manifestations of Albinism Pigmented Lesions of the Eyelid Postinflammatory Hyperpigmentation Vitiligo [dokterairlangga.com]

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Turner Syndrome

An association with many autoimmune diseases is described as well as skin diseases such as psoriasis, vitiligo and alopecia areata. [ncbi.nlm.nih.gov]

0011307 Strabismus Cross-eyed Squint Squint eyes [ more ] 0000486 Type II diabetes mellitus Noninsulin-dependent diabetes Type 2 diabetes Type II diabetes [ more ] 0005978 Vitiligo [rarediseases.info.nih.gov]

Skin lymphoedema - hands, feet, neck (pterygium coli), pigmented naevi, telangiectasias, vitiligo, keloid, seborrhoeic dermatitis; increased body hair with alopecia. [patient.info]

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Acute Hepatic Porphyria

Alnylam presented results from their phase 3 ENVISION trial, which assessed givosiran for acute hepatic porphyria (AHP), at the European Association for the Study of the Liver (EASL) International Liver Congress in Vienna, Austria. ENVISION was a randomized, double-blind, placebo-controlled, global, multicenter study[…] [trialsitenews.com]

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Viral Exanthem

Some people with vitiligo also have patches of pigment loss affecting the hair on their scalp or body. Researchers have identified several forms of vitiligo. [ghr.nlm.nih.gov]

Overview Vitiligo (vit-ih-LIE-go) is a disease that causes the loss of skin color in blotches. The extent and rate of color loss from vitiligo is unpredictable. [mayoclinic.org]

Non-segmental vitiligo If the first white patches are symmetrical, this suggests a type of vitiligo known as non-segmental vitiligo. [medicalnewstoday.com]

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Autoimmune Gastritis

Keywords : Anemia, Gastritis, Glossitis, Helicobacter pylori, Vitiligo. [casereports.in]

[…] anemia was present in 25% of patients, iron deficiency anemia was found in 29.7% of patients, hypothyroidism in 23% of patients, type 1 diabetes in 7.9% of patients, and vitiligo [ncbi.nlm.nih.gov]

Dermatologist opinion was sought for the well-demarcated hypo-pigmented patches and was diagnosed as vitiligo. [casereports.in]

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Variegate Porphyria

[…] may be limited; that CLINUVEL may never file an NDA for SCENESSE regulatory approval in the US; that the Company may not be able to access adequate capital to advance its vitiligo [porfiria.org]

It will also be the first experience of a 28-day dosing cycle in any porphyria, mirroring that used in our vitiligo program,” Dr Rodenburger said. – End – 1 SCENESSE (afamelanotide16mg [porfiria.org]

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Localized Scleroderma

Figure 1 Vitiligo and morphea lesions on the lower limbs. [bmcresnotes.biomedcentral.com]

Ilse Mollet, Nanny van Geel and Jo Lambert, Autoimmune/Inflammatory and Other Diseases Associated with Vitiligo, Vitiligo, 10.1007/978-3-540-69361-1_11, (79-90), (2010). [doi.org]

[…] disorders--there are reports of combinations with other autoimmune diseases such as systemic sclerosis, systemic lupus erythematosus, Hashimoto thyroiditis, Sjogren syndrome, vitiligo [ncbi.nlm.nih.gov]

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Tinea Versicolor

Tinea versicolor usually appears on parts of the body distinct from the areas where vitiligo is normally found. [yeastinfection.org]

Pityriasis versicolor or vitiligo? Pityriasis versicolor can sometimes be confused with vitiligo, as they both cause the skin to become discoloured in patches. [nhs.uk]

But there are ways to tell the difference: vitiligo often develops on both sides of your body at the same time, whereas pityriasis versicolor may not skin affected by vitiligo [nhs.uk]

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Porphyria Cutanea Tarda

He reported a 25 year-old history of vitiligo upon exposure to sunlight. [ncbi.nlm.nih.gov]

Jansen T, Megahed M, Hölzle E, Plewig G: Provocation of porphyria cutanea tarda by KUVA therapy of vitiligo. Acta Derm Venereol (Stockh) 1995;75:232–233. [karger.com]

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Thyroiditis

KEYWORDS: Autoimmune thyroiditis; CCL2; CXCL10; Chemokines; Vitiligo [ncbi.nlm.nih.gov]

Vitiligo and overt thyroid diseases: a nationwide population-based study in Korea. J Am Acad Dermatol. 2017 May. 76 (5):871-8. [Medline]. [emedicine.com]

Abstract Recently the importance of CXCL10 in the pathogenesis of non-segmental vitiligo (NSV) and autoimmune thyroid disorders (AITD) has been shown. [ncbi.nlm.nih.gov]

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Skin Disease

The epidemiology of childhood vitiligo. Turkderm 2006;40:81-6. 18- Kose O, Ozmen I. Childhood vitiligo. [pediatricsciences.com]

Common Skin Diseases in Children Ringworms, psoriasis, eczema, chicken pox, measles, cold sore, rosacea, seborrheic eczema, vitiligo, hives, carbuncle, warts, hemangioma of [medindia.net]

Vitiligo Vitiligo is a disorder that causes patches of skin to become white. It happens because cells that make color in your skin are destroyed. [niams.nih.gov]

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Homocystinuria

[…] signs of homocystinuria include: Hypopigmentation due to inhibition of tyrosinase Fair and thin hair Thin, translucent skin Hyperhidrosis Dry skin with tendency to eczema Vitiligo [dermnetnz.org]

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Autoimmune Adrenal Insufficiency

The main autoimmune diseases in AD: thyroid diseases – 34%, premature ovarian failure (POF) – 14%, IDDM and vitiligo – 13%, while in SAI – 36, 4, 3 and 4% respectively. [endocrine-abstracts.org]

Conclusions: A history of multiple endocrinopathies such as autoimmune thyroiditis, type I diabetes mellitus, vitiligo and POF should alert the clinician that the patient [shmabstracts.com]

[…] differences between the both groups concerned age at time of diagnosis, F/M ratio, type of electrolyte disturbances, frequency of adrenal crisis, frequency of POF, IDDM and vitiligo [endocrine-abstracts.org]

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Vitamin B12 Deficiency

Skin Lesions, Vitiligo, And Sore Tongue Any change in the B12 content in the body can lead to skin problems like vitiligo, dermatitis, hyperpigmentation, or acne. [curejoy.com]

For example, thyroid diseases, Addison's disease and vitiligo (a condition where white patches develop on skin). [patient.info]

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Zosteriform Lentiginosis

259 Fig. 10.1 Vitiligo. [plasticsurgerykey.com]

(PDF) Vitiligo developing in congenital segmental speckled ... ; Jul 21, 2017 ... [ydntrbcb.cf]

; Keywords: Halo nevus, Nevus spilus, Vitiligo. Go to: .... A case of giant congenital nevocytic nevus with neurotization and onset of vitiligo. [zshezuvg.cf]

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Lichen Sclerosus

Its resemblance to vitiligo, especially during the earlier stages, leads to delay in its diagnosis. [ncbi.nlm.nih.gov]

In light of the association between autoimmune disorders and lichen sclerosus, a brief examination for alopecia areata and vitiligo is reasonable. [cancertherapyadvisor.com]

[…] autoimmune disease, and 42% had autoimmune antibodies. 4 The most common autoimmune diseases associated with lichen sclerosus are autoimmune thyroiditis, alopecia areata, vitiligo [clinicaladvisor.com]

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Hashimoto Thyroiditis

Abstract Autoimmune thyroid diseases (AITDs) are often accompanied by vitiligo, and the sera of patients with vitiligo often demonstrate increased frequencies of thyroid autoantibodies [ncbi.nlm.nih.gov]

/complications Vitiligo/immunology* Substances Antigens, CD19 CD19 molecule, human CD24 Antigen CD24 protein, human IL10 protein, human Membrane Glycoproteins Tumor Necrosis [ncbi.nlm.nih.gov]

Skin diseases were diagnosed in both cohorts with a similar prevalence, vitiligo being the most common. [eje.bioscientifica.com]

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Autoimmune Polyendocrine Syndrome Type 2

We communicate the case of a 61 year-old woman with vitiligo diagnosed with Addison’s disease and Hashimoto’s thyroiditis (Schmidt’s syndrome). [new.medigraphic.com]

Our proband is a 12-year-old boy with Addison disease, insulin dependent diabetes mellitus (IDDM), and vitiligo. [ncbi.nlm.nih.gov]

Additional endocrine (hypogonadism, hypoparathyroidism) and non-endocrine diseases (vitiligo, autoimmune hepatitis, autoimmune gastritis, pernicious anemia, and myasthenia [orpha.net]

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Autoimmune Polyendocrine Syndrome

AA and vitiligo in our series occurred in the setting of established disease. [ncbi.nlm.nih.gov]

Type 1 diabetes, Graves' disease, Hashimoto thyroiditis, Addison's disease, vitiligo, alopecia, hypogonadism, and pernicious anemia were observed in 61%, 33%, 33%, 19%, 20% [ncbi.nlm.nih.gov]

Type 1 diabetes, alopecia, vitiligo, ectodermal dystrophy, celiac disease and other intestinal dysfunctions, chronic atrophic gastritis, chronic active hepatitis, autoimmune [ncbi.nlm.nih.gov]

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Piebaldism

BACKGROUND: Refractory and stable defects of vitiligo and piebaldism may be unresponsive to medical therapy. [ncbi.nlm.nih.gov]

In patients with stable vitiligo who fail conventional therapies, surgical transplant offers a viable alternative. [ncbi.nlm.nih.gov]

Unlike vitiligo, the hands, feet and hips are often spared. [vitiligocenter.eu]

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Trachonychia

Trachonychia is often seen in vitiligo patients – suggesting that they are more susceptible to this condition. [findwords.info]

It has also been associated with other diseases such as eczema, psoriasis, alopecia areata, and atopic dermatitis. [2] Trachonychia is often seen in vitiligo patients – suggesting [medbox.iiab.me]

Furthermore, the coexistence of vitiligo and AS already reported in the literature. At last, AS, vitiligo, and AA diagnosed in this patient in prospectives examinations. [e-ijd.org]

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Alopecia

463–469, AUG 2016 DOI: 10.1097/MOP.0000000000000375, PMID: 27191524 Issn Print: 1040-8703 Publication Date: 2016/08/01 Checking for direct PDF access through Ovid Abstract Vitiligo [doi.org]

Clinical presentations of vitiligo and alopecia areata A-B) Common vitiligo on the anticubital fossa and extensor knees of a 9-year-old male; C) Segmental vitiligo in a 15 [ncbi.nlm.nih.gov]

Khellin is a furanochromone photosensitizer whose chemical structure is close to psoralens and has previously proven its efficacy in vitiligo in association with ultraviolet [ncbi.nlm.nih.gov]

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Ermine Phenotype

Vitiligo may be hereditary and run in families. Children whose parents have the disorder are more likely to develop vitiligo. [viticlear.com]

Vitiligo may be hereditary in some cases. Children of vitiligo affected parents are more likely to develop vitiligo disorder. [medhelp.org]

[…] to cause vitiligo. [crutchfielddermatology.com]

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Autoimmune Disease

This review discusses these under-investigated facets of vitiligo onset and progression; hence, it is expected to enrich vitiligo research. [ncbi.nlm.nih.gov]

Psoriatic arthritis (adjusted odds ratio (OR) 10.08; 7.97-12.74), rheumatoid arthritis (adjusted OR 6.61; 2.75-15.87) and vitiligo (adjusted OR 4.76; 1.71-13.20) showed strong [ncbi.nlm.nih.gov]

Fashion model Chantelle Brown is known for speaking up about her vitiligo and how the disease affects the health of sufferers, as well as the social problems people with vitiligo [labiotech.eu]

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Alopecia Universalis

We report a case of an unknown clinical combination of PCT with autoimmune hypothyroidism, alopecia universalis and vitiligo with thyroid and parietal cell circulating antibodies [ncbi.nlm.nih.gov]

Those with vitiligo (patchy loss of skin color) may also develop alopecia universalis in time. [streetdirectory.com]

[…] be seen occasionally The cause is thought to be an autoimmune phenomenon as often; there is a co-existing autoimmune disease e.g. pernicious anaemia, thyroid disorders, vitiligo [gpnotebook.co.uk]

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