Bone Destruction: Causes & Reasons

Possible Causes for Bone Destruction

(PMID: 18270207) Rismanchi N … Blackstone C (Human molecular genetics 2008) 2 3 4 60 Sensory neuropathy with bone destruction due to a mutation in the membrane-shaping atlastin [genecards.org]

There are reports of Charcot joints in these individuals due to repeated bone injury and the destruction of surrounding soft tissue/joints. [medicalbag.com]

destruction, and amputation. [genecards.org]

Periodontitis

^ Carranza, FA: Bone Loss and Patterns of Bone Destruction. [en.wikipedia.org]

The relationship between OPN and bone destruction during periapical periodontitis was analyzed. [ncbi.nlm.nih.gov]

These results indicated that the bone destruction level expanded from days 7 to 35. [ncbi.nlm.nih.gov]

Bone Metastasis

Most often, radiation therapy, bisphosphonates, and RANKL inhibitors are used to slow bone destruction. [merckmanuals.com]

Early use of radiation (ranging from single treatment 8 Gy to multiple treatments to 30 Gy) and bisphosphonates (eg, zoledronate, pamidronate) or denosumab slows bone destruction [msdmanuals.com]

Early use of radiation (30 Gy) and bisphosphonates (eg, zoledronate, pamidronate ) or denosumab slows bone destruction. [merckmanuals.com]

Malignant Neoplasm of the Bone

[…] of an aggressive bone lesion with typical bone destructive patterns. [podiatrytoday.com]

bone destruction are noted in the flat and long bones, • if these appear about the cortex, they are accompanied by scalloping of the inner cortical margin • Fewer than 1% [slideshare.net]

Osteosarcoma of cortical bone - Lytic lesion with evidence of BOTH bone destruction and bone formation mutations in Rb and P53 Osteosarcoma - reactive bone formation shows [quizlet.com]

Neoplasm of the Bone

[…] of an aggressive bone lesion with typical bone destructive patterns. [podiatrytoday.com]

Bone Tumors Clues and Cues Bone Tumors Clues and Cues Clues by Appearance of Lesion Patterns of Bone Destruction  Geographic  Moth-eaten  Permeative Geographic Bone Destruction [learningradiology.com]

There are three types of bone destructive patterns: geographic, moth-eaten and permeative. Benign bone lesions typically display geographic bone destruction. [podiatrytoday.com]

Gorham-Stout Disease

We present CT and MRI findings of the disease and serial radiography following the progressing bone destruction. [ncbi.nlm.nih.gov]

J Bone Joint Surg [Am] 1955;37-A:985-1004. ^ a b c d Ross JL., Schinella R., and Shenkman L. Massive osteolysis: An unusual cause of bone destruction. [en.wikipedia.org]

Massive osteolysis of Gorham is a clinical, radiographic, and histologic entity characterized by histologically benign vascular proliferation involving bone associated with [ncbi.nlm.nih.gov]

Chronic Pyogenic Osteomyelitis

Langerhans cell histiocytosis of bone causes bone destruction and frequent bone reactions Hat mimic benign and malignant neoplasms as well as osteomyelitis. 14. [sentencedict.com]

Bacterial growth results in bone destruction and formation of an abscess. [medical-dictionary.thefreedictionary.com]

destruction surrounded by sclerosis Chronic disease may resemble malignant bone tumor due to destructive and regenerative bone changes Radiology images Contributed by Dr. [pathologyoutlines.com]

Fungal Osteomyelitis

However, computer tomography and X-ray examination showed massive bone destruction at 48 days after ACL reconstruction. [ncbi.nlm.nih.gov]

Bacterial growth results in bone destruction and formation of an abscess. [medical-dictionary.thefreedictionary.com]

As soon as there are sinuses, and grains are recognized, and particularly when there is bone destruction, the diagnosis of mycetoma is straightforward: defining the causative [isradiology.org]

Bone Lymphoma

For plain film presentation of permeative bone destruction consider 1 : infection eosinophilic granuloma Ewing sarcoma skeletal metastases [radiopaedia.org]

Primary bone lymphomas are rare tumours. 2. Imaging studies characteristically show extensive lytic bone destruction with soft tissue infiltration. 3. [ncbi.nlm.nih.gov]

The most common is a lytic pattern with permeative bone destruction and a wide zone of transition 1. MRI Associated soft tissue masses are common. [radiopaedia.org]

Bone Marrow Metastasis

destruction, walking ability before fracture, general complications, the number of bone metastases in other sites, and the visceral metastasis status. [ncbi.nlm.nih.gov]

Some mechanisms of local bone destruction by squamous carcinomas of the head and neck. [ncbi.nlm.nih.gov]

Most often, radiation therapy, bisphosphonates, and RANKL inhibitors are used to slow bone destruction. [msdmanuals.com]

Orbital Neoplasm

Citation: Yan J, Zhou S, Li Y (2012) Benign Orbital Tumors with Bone Destruction in Children. [journals.plos.org]

Molds to the contour of the orbit without bone destruction, unless it is very aggressive. 15. [slideshare.net]

Bone destruction indicates aggressive neoplasia, while moulding indicates slow-growing benign tumours. [karger.com]

Osteomyelitis

Bone destruction of head of 2 nd metatarsal with periosteal new bone formation characteristic of osteomyelitis [learningradiology.com]

Osteomyelitis, an inflammatory process accompanied by bone destruction, is caused by infective microorganisms. [ncbi.nlm.nih.gov]

destruction, is caused by infective microorganisms. [web.archive.org]

Aggressive Periodontitis

The disease entity includes two manifestations of aggressive bone destruction, a localized and a generalized form, which affect adolescents at puberty. [experts.umich.edu]

Thereafter, the destruction of the cortical bone occurs. [dentalhypotheses.com]

This is questioned in the present study, which suggests that the localized "bone destruction" is not destruction but lack of alveolar bone apposition during pubertal growth [dentalhypotheses.com]

Spinal Tuberculosis

MRI of spine shows areas of bone destruction in T1, T4, T5, T10 and T12 vertebral bodies and it looks like a round of bone destruction (Figure 5). [panafrican-med-journal.com]

The presence of advanced bone destruction with severe instability was demonstrated on the MRI scan done later. [ncbi.nlm.nih.gov]

METHODS: A total of 19 cases with thoracic tuberculosis, neurological deficit and bone destruction (without severe kyphosis) admitted to the hospital from May 2005 to January [ncbi.nlm.nih.gov]

Tuberculosis of the Pelvic Bone

In low-prevalence countries, skeletal manifestations usually present with less severe bone destruction. [link.springer.com]

Involvement of flat bones like innominate bone is a rare entity, true incidence not being known Radiographs reveal irregular cavities and areas of bone destruction with little [ijri.org]

destruction which continues down into the lower part of the pelvis, the ischium. [northumberlandarchives.com]

Plasmacytoma

In this paper, we present a patient with nonsecretory multiple myeloma, who suffered from distal humerus fracture with severe bone destruction, renal failure, hypercalcemia [ncbi.nlm.nih.gov]

Imaging revealed underlying bone destruction. [ncbi.nlm.nih.gov]

[…] plasmacytoma is pain at the site of the skeletal lesion due to bone destruction by the infiltrating plasma cell tumor. [radiopaedia.org]

Aneurysmal Bone Cyst

A 15-year-old boy presented with a left-sided intrathoracic mass displacing the lung without bone destruction. [ncbi.nlm.nih.gov]

Aneurysmal bone cysts (ABCs) are rare, rapidly expansile, benign, vascular lesions capable of causing local bone destruction. [ncbi.nlm.nih.gov]

The bone destruction in both giant cell tumors of bone and ABCs is mediated by RANK ligand (RANKL) produced by the tumor cells. [ncbi.nlm.nih.gov]

Neuropathic Arthropathy

Fig. 16.2 Destructive bone changes of the lumbar spine in a 47-year-old man with traumatic paraplegia. a Axial CT image at level L4 shows bone destruction with fragmentation [radiologykey.com]

For example, mild and painless swelling of the foot joints may often mask extremely severe bone destruction. [books.google.com]

Introduction Clinical definition arthropathy due to underlying neuropathy or trauma, leading to a destruction of joints and bone Epidemiology demographics adults location [medbullets.com]

Mandibular Neoplasm

CT is indicated for assessment of bone destruction in the mandible before surgery or radiation therapy. [ncbi.nlm.nih.gov]

Imaging features include bone destruction with a multilocular or cyst-like radiolucent appearance. [karger.com]

The criteria for the diagnosis of central MEC include cortical bone void of perforation by tumor invasion, radiological evidence of bone destruction, and histopathological [karger.com]

Tuberculosis of the Skeletal System

Complications Progressive bone destruction leads to vertebral collapse and kyphosis: The spinal canal can be narrowed by abscesses, granulation tissue, or direct dural invasion [patient.info]

Lesions undergo bone formation early & destruction in later stage (new bone formed on surface). [quizlet.com]

The disease has a progressive course and the diagnosis is often made in the later stages of bone destruction. [jmm.microbiologyresearch.org]

Osteomyelitis of the Petrous Bone

destruction. [ncbi.nlm.nih.gov]

Planar images were equivocal, but SPECT/CT showed intense uptake in the body of sphenoid and petrous temporal bone as well as the atlas corresponding to irregular bone destruction [link.springer.com]

[…] skull of a patient with SBO involving the left mastoid bone with corresponding destructive bony changes Click here to view Figure 4: Computed tomography (CT), single photon [ijnm.in]

Osteomyelitis of the Tibia

Bone destruction of head of 2 nd metatarsal with periosteal new bone formation characteristic of osteomyelitis [learningradiology.com]

Bacterial growth results in bone destruction and formation of an abscess. [medical-dictionary.thefreedictionary.com]

Vertebral Osteomyelitis due to Salmonella

Langerhans cell histiocytosis of bone causes bone destruction and frequent bone reactions Hat mimic benign and malignant neoplasms as well as osteomyelitis. 14. [sentencedict.com]

Bacterial growth results in bone destruction and formation of an abscess. [medical-dictionary.thefreedictionary.com]

Acroosteolysis

Manifestations of Sarcoid Punched-out lytic lesions Lace-like destruction Bone stones (acro-osteosclerosis) Bone destruction with/without pathologic fracture Acro-osteolysis [learningradiology.com]

destruction, and surgery. [dovemed.com]

Acroosteolysis Phalangeal Type ► [Bone resorption of multiple phalangeal tufts] Bone destruction at the terminal phalanges occurs in a variety of congenital and acquired disorders [rrnursingschool.biz]

Osteomyelitis of the Foot

destruction by increased osteoclastic activity and bone synthesis (1). [radiologyassistant.nl]

In the presence of a foot ulcer there is a risk of the underlying bones being involved. X-ray may show bone destruction. [sydney.edu.au]

Crepitus, palpable loose bodies and large osteophytes are the result of extensive bone and cartilage destruction. [radiologyassistant.nl]

Chondroblastoma

The patterns of bone destruction were evaluated as Lodwick Class IA in six patients, Lodwick Class IB in five, and Lodwick Class IC in two. [ncbi.nlm.nih.gov]

Computed tomography (CT) scan showed a well-defined oval 49 mm × 43 mm lesion with the lytic bone destruction of the rib. [jtd.amegroups.com]

RESULTS: All 31 lesions (18 tubular bones, 13 NTBs) exhibited geographic bone destruction and did not involve the adjacent joints. [ncbi.nlm.nih.gov]

Middle Ear Cholesteatoma

A novel scoring system, the Bone Erosion Score (BES), was developed to estimate the severity of bone destruction. [ncbi.nlm.nih.gov]

Abstract One of the most distinct characteristics of middle ear cholesteatomas is their capacity for bone destruction during the growth process. [ncbi.nlm.nih.gov]

Middle ear cholesteatomas are characterized by the presence of stratified squamous epithelium in this cavity with highly invasive properties causing bone destruction and it [ncbi.nlm.nih.gov]

Bone Cyst

ABCs are potentially more aggressive, with a risk of bone destruction. [ncbi.nlm.nih.gov]

destructive, blood filled lesions of bone with unknown cause and unusual presentations. [casereports.in]

Be aware, however, that what may appear to be cortical destruction may actually be cortical bone replacement by a fibrous or chondroid matrix, which is non-calcified and may [imageinterpretation.co.uk]

Septic Arthritis of Pelvic Region

The operative management of SIJ infections, from our experience, consists of debridement in cases of acute soft tissue infection or cases of mild bone destruction. [link.springer.com]

By rule, sequestra are rarely formed, there are no greater bone destructions, but there is usually early bone sclerosing. [ncbi.nlm.nih.gov]

Imaging – Xray, CT, MRI --------less helpful in diagnosisCan demonstrate• Joint effusion • Synovial thickening • Perisynovial edema • Cartilage destruction • Bone destruction [slideshare.net]

Joint Tuberculosis

In contrast, in the two patients with ankle or elbow joint involvement and bone destruction, arthroscopy had to be converted to open operation. [ncbi.nlm.nih.gov]

destruction with relative disc preservation and paravertebral and epidural soft tissue masses are observed. [ncbi.nlm.nih.gov]

Figure 21 Sacral involvement with bone destruction and large presacral soft tissue component. [ispub.com]